Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 80, Issue 13, Pages 6915-6921Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b00989
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Funding
- DST-SERB [SR/FT/CS-168/2011]
- CSIR
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Molecular iodine catalyzed oxidative coupling of 2-aminobenzamides with aryl methyl ketones produced 2-aryl quinazolin-4(3H)-ones. The reaction performed well in the absence of any metal or ligand. The quantity of iodine played a very crucial role in this transformation in order to selectively get 2-aryl quinazolin-4(3H)-ones. The utility of this protocol for synthesis of pyrazolo[4,3-d]pyrimidin-7(6H)-ones including a key intermediate involved in sildenafil synthesis has also been demonstrated.
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