Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 80, Issue 11, Pages 5906-5911Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b00242
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Funding
- Shanghai Rising-Star Program [13QA1401200]
- Doctoral Fund of the Ministry of Education of China [20110074120008]
- National Natural Science Foundation of China [21106043, 21372080]
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Classic fluorescent dyes, such as coumarin, naphthalimide, fluorescein, BODIPY, rhodamine, and cyanines, are cornerstones of various spectroscopic and microscopic methods, which hold a prominent position in biological studies. We recently found that 9-amino-benzo[c]cinnoliniums make up a novel group of fluorophores that can be used in biological studies. They are featured with a succinct conjugative push-pull backbone, a broad absorption band, and a large Stokes shift. They are potentially useful as a small-molecule alternative to R-phycoerythrin to pair with fluorescein in multiplexing applications.
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