Article
Fisheries
Hongfei Tian, Jing Xing, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan
Summary: Cytokines are small molecular proteins secreted by immune cells to regulate cell growth, differentiation, and effects. T cells have been identified in fish and shown to be involved in the immune response. However, research on fish T cell identification and differentiation is still in its early stages and requires more effort.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Cell Biology
Tania Vico, Catrin Youssif, Fathema Zare, Monica Comalada, Carlos Sebastian, Jorge Lloberas, Antonio Celada
Summary: In this study, it was found that GM-CSF provides better protection against DNA damage and promotes faster DNA repair in macrophages compared to M-CSF. The presence of M-CSF resulted in a higher number of apoptotic cells after DNA damage. The protective effect of GM-CSF against DNA damage is associated with its induction of differentiation markers and pro-survival protein.
Article
Multidisciplinary Sciences
Atsuo Nakamura, Shin Kurihara, Daisuke Takahashi, Wakana Ohashi, Yutaka Nakamura, Shunsuke Kimura, Masayoshi Onuki, Aiko Kume, Yukiko Sasazawa, Yukihiro Furusawa, Yuuki Obata, Shinji Fukuda, Shinji Saiki, Mitsuharu Matsumoto, Koji Hase
Summary: This study reveals that polyamines produced by intestinal bacteria have beneficial effects on enhancing colonic barrier function and immunity by increasing regulatory macrophage abundance and being taken up by colonic epithelial cells.
NATURE COMMUNICATIONS
(2021)
Article
Fisheries
Amro M. Soliman, Daniel R. Barreda
Summary: Acute inflammation plays a crucial role in the immune responses of fish, protecting the host from infection and promoting tissue repair. Inflammatory signals and mediators drive leukocyte recruitment, antimicrobial mechanisms, and resolution of inflammation. Understanding the kinetics and unique characteristics of fish inflammation is important for studying fish diseases and potential treatments.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eisaku Ogawa, Tomohiro Edamitsu, Hidetaka Ohmori, Kazuyoshi Kohu, Mineo Kurokawa, Hiroshi Kiyonari, Masanobu Satake, Ryuhei Okuyama
Summary: This study reveals the important roles of Runx1 and Runx3 in keratinocyte differentiation, where they directly inhibit the expression of keratin 1 and keratin 10 genes during the differentiation process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alekh Paranjapye, Monali NandyMazumdar, James A. Browne, Shih-Hsing Leir, Ann Harris
Summary: This study characterizes the role of KLF5 in controlling essential pathways of epithelial cell identity and function in the human lung. Results show that KLF5 plays a key role in regulating genes involved in cell adhesion and proinflammatory response, highlighting its pivotal role in coordinating epithelial functions relevant to human lung disease.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Qingjing Hu, Wanyu Zhao, Keming Qu, Ning An, Lingxiao Li, Yuqiu Wei, Ying Bai, Tao Jiang, Jufa Chen, Fangqun Dai, Hongsheng Wang, Zhengguo Cui
Summary: In this study, the muscle TMAO content of 152 teleost fishes from marginal seas of China and the epipelagic zone of the northwest Pacific Ocean was measured. The results showed significant variations in TMAO content among different species, and species played a more important role than environmental factors in driving TMAO accumulation. Additionally, temperature was identified as a key environmental factor affecting the TMAO content of teleost fishes in shallow seas and the epipelagic zone of the deep ocean.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biology
Jerome Roy, Frederic Terrier, Michael Marchand, Alexandre Herman, Cecile Heraud, Anne Surget, Anthony Lanuque, Franck Sandres, Lucie Marandel
Summary: This study demonstrates that lower stocking density significantly affects the growth, survival, and physiological responses of rainbow trout, inducing chronic stress and altering inflammatory and immune systems. Selecting appropriate fish density in aquaculture is crucial for improving welfare and optimal growth.
Article
Biochemistry & Molecular Biology
Yan-Rong Feng, Sayed Haidar Abbas Raza, Cheng-Cheng Liang, Xiao-Yu Wang, Jian-Fang Wang, Wen-Zheng Zhang, Linsen Zan
Summary: CREB1 plays an important role in Qinchuan bovine skeletal myoblasts, promoting cell proliferation and differentiation by mediating the transcription of CCNA2 and MyoG. It is involved in cell proliferation, myogenic differentiation, and skeletal muscle repair pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Physiology
Li Liu, Elisabeth Bankell, Catarina Rippe, Bjorn Moren, Karin G. Stenkula, Bengt-Olof Nilsson, Karl Sward
Summary: Myocardin related transcription factors play a key role in smooth muscle cell differentiation, with both anti-inflammatory and pro-inflammatory properties observed in different cell types. The impact of these factors on inflammatory signaling pathways remains complex and cell-type dependent.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Fisheries
Charles Brighton Ndandala, Mingshu Dai, Umar Farouk Mustapha, Xiaomeng Li, Jinlei Liu, Hai Huang, Guangli Li, Huapu Chen
Summary: The GH-IGFs axis is essential in regulating physiological functions in teleost fish. Nutritional status and fasting/refeeding have significant effects on the expression of IGF genes. IGFs play crucial roles in growth, reproduction, and other physiological functions in teleost fish.
AQUACULTURE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Wenwen Wang, Suxu Tan, Yujia Yang, Tao Zhou, De Xing, Baofeng Su, Jinhai Wang, Shangjia Li, Mei Shang, Dongya Gao, Rex Dunham, Zhanjiang Liu
Summary: This study investigated the global DNA methylation and gene expression profiles during early sex differentiation after E2 treatment in channel catfish. The results showed that E2 treatment caused differential methylation and expression of a specific set of genes involved in sex differentiation-related pathways. E2 treatment induced sex reversal in genetic males, but did not affect methylation or gene expression within the sex determination region.
Article
Biochemistry & Molecular Biology
Noel Blanco-Tourinan, Hector H. Torres-Martinez, Frauke Augstein, Chloe Champeyroux, Claudia von der Mark, Annelie Carlsbecker, Joseph G. Dubrovsky, Antia Rodriguez-Villalon
Summary: The connection between the vasculature of the primary root and the emerging lateral roots is established through coordinated actions of the procambium and pericycle. The formation of a xylem bridge, consisting of xylem cells derived from the procambium and pericycle, is crucial for this vascular connectivity. Transcription factors and the deposition of secondary cell walls play important roles in the specification and differentiation of the xylem bridge.
Article
Engineering, Marine
Tomas arnason, Heiodis Smaradottir, Helgi Thorarensen, Agnar Steinarsson
Summary: The effects of early thermal environment on growth, age at maturity, and sexual size dimorphism in Arctic charr were investigated. The study found that higher temperatures increased growth rates but also caused precocious sexual maturation and reduced long-term growth performance. Furthermore, elevated temperatures had a stronger impact on female maturity incidence and were positively associated with sexual size dimorphism.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Cell Biology
Peter-Paul A. Unger, Niels J. M. Verstegen, Casper Marsman, Tineke Jorritsma, Theo Rispens, Anja ten Brinke, S. Marieke van Ham
Summary: Efficient differentiation of human naive B cells into antibody-secreting cells can be achieved by controlling the interaction between CD40 costimulation and Tfh cell-associated cytokines IL-21 and IL-4 in an in vitro culture system. Renewed CD40 costimulation in vitro can induce rapid terminal ASC differentiation after initial B-cell expansion, similar to the process in vivo.
Article
Immunology
Youngjin Park, Isabel S. Abihssira-Garcia, Sebastian Thalmann, Geert F. Wiegertjes, Daniel R. Barreda, Pal A. Olsvik, Viswanath Kiron
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Ecology
Alexander J. Douglas, Laura A. Hug, Barbara A. Katzenback
Summary: Different bacterial skin microbiome compositions were found in North American wood frogs based on seasons and locations, with no significant effect of sex on microbiota diversity observed. The study indicates significant seasonal variation in wood frog skin microbiome structure, while the average diversity per frog remained consistent.
Article
Parasitology
Brooke A. McPhail, Sydney P. Rudko, Alyssa Turnbull, Michelle A. Gordy, Ronald L. Reimink, Daniel Clyde, Kelsey Froelich, Sara Brant, Patrick C. Hanington
Summary: The study identified different species of snails as potential intermediate hosts for avian schistosomes, with phylogenetic analysis confirming the categorization of a specific type of snail as part of the avian schistosome clade. Additionally, preliminary research was conducted on cercariae produced by snails to investigate their potential to cause swimmer's itch.
JOURNAL OF PARASITOLOGY
(2021)
Review
Immunology
Jacob R. Hambrook, Patrick C. Hanington
Summary: Human schistosomes have evolved various immune evasion strategies, such as molecular mimicry of host antigens and the utilization of an immune resistant outer tegument, to survive in both snail and human hosts. Understanding these mechanisms is crucial for the development of novel therapeutics and treatment plans.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Clayton T. James, Marie F. Veillard, Amanda M. Martens, Emmanuel A. Pila, Alyssa Turnbull, Patrick Hanington, Andreas Luek, Julie Alexander, R. Barry Nehring
Summary: The study documents the impact of whirling disease on wild rainbow trout populations in Canada, with evidence of high infection rates and severe effects on fish survival in the Crowsnest River in Alberta. The findings highlight the emergence of whirling disease as a significant threat to wild salmonid populations in the region.
CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES
(2021)
Article
Fisheries
Maxwell P. Bui-Marinos, Lauren A. Todd, Marie-Claire D. Wasson, Brandon E. E. Morningstar, Barbara A. Katzenback
Summary: The study found that Xenopus laevis skin epithelial cells are susceptible and permissive to Frog virus 3 (FV3), but do not exhibit appreciable levels of scavenger receptors needed for FV3 cellular entry. These cells show antiviral and proinflammatory responses to poly(I:C), but not to FV3 or UV-inactivated FV3. Pretreatment with poly(I:C) can limit FV3 replication and cytopathic effects in these cell lines.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Hongyu Li, Abdullah A. Gharamah, Jacob R. Hambrook, Xinzhong Wu, Patrick C. Hanington
Summary: The study compared immune cells of snail Biomphalaria glabrata, revealing that hyalinocytes mainly produce immune effectors while granulocytes are responsible for producing fibrinogen-related proteins. Granulocytes also possess pattern-recognition receptors that play a role in the anti-S. mansoni immune response.
Article
Parasitology
Sydney P. Rudko, Brooke A. McPhail, Ronald L. Reimink, Kelsey Froelich, Alyssa Turnbull, Patrick C. Hanington
Summary: To control swimmer's itch in northern Michigan inland lakes, the relocation of common mergansers has been attempted since 2015. However, this study suggests that targeting a single species of parasite and removing the common merganser is not an effective control strategy, likely due to parasite contributions from non-resident birds.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2022)
Article
Immunology
Amro M. Soliman, Taekwan Yoon, Jiahui Wang, James L. Stafford, Daniel R. Barreda
Summary: The study investigates the kinetics of leukocyte recruitment in fish skin infections, demonstrating early upregulation of inflammatory cytokines and migration of neutrophils to the injury site. Resolution of inflammation is marked by reduction in reactive oxygen species and pro-inflammatory cytokines expression.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Microbiology
Brooke A. McPhail, Kelsey Froelich, Ronald L. Reimink, Patrick C. Hanington
Summary: Avian schistosomes are a public health nuisance that researchers monitor through snail collections and cercariometry. The evolution of cercariometry methods has simplified parasite monitoring, and it can be complemented with environmental DNA to understand the composition of avian schistosomes.
Article
Microbiology
Jacob Hambrook, Patrick G. Hanington
Summary: Schistosoma mansoni uses immune evasion and immunosuppression to overcome immune responses from both its snail and human hosts. It releases a protease called SmCI-1 that creates an immunological environment favorable for the parasite's survival. SmCI-1 functions as a metalloprotease that cleaves various proteins, including collagen type IV, gelatin, fibrinogen, and complement component C3b. It protects schistosomula from complement-mediated lysis and promotes an anti-inflammatory microenvironment in human peripheral blood mononuclear cells.
Article
Biology
Farah Haddad, Amro M. Soliman, Michael E. Wong, Emilie H. Albers, Shawna L. Semple, Debora Torrealba, Ryan D. Heimroth, Asif Nashiry, Keith B. Tierney, Daniel R. Barreda, Ruslan Medzhitov
Summary: Multiple lines of evidence support the value of moderate fever in host survival, but the mechanisms involved are still unclear. By using a cold-blooded fish model, researchers were able to study the natural kinetics of fever induction and regulation, as well as a wide range of tolerated temperatures. The results showed that fever activates specific immune mechanisms, improves pathogen clearance, inhibits inflammation, and enhances wound repair. Artificial hyperthermia, commonly used as a fever model, partially replicates the benefits of natural fever. Overall, this study defines fever as an integrative host response that regulates acute inflammation, and demonstrates its importance in the evolution of organisms.
Article
Fisheries
Danielle E. Barry, Marie Veillard, Clayton T. James, Leah Brummelhuis, Emmanuel A. Pila, Alyssa Turnbull, Arnika Oddy-van Oploo, XinNeng Han, Patrick C. Hanington
Summary: The study conducted a 3-year monitoring program in Alberta, Canada for the whirling disease causing parasite Myxobolus cerebralis, introducing a qPCR test for environmental and worm samples. A total of approximately 1500 environmental samples and 567 oligochaete specimens were collected and tested, with results indicating that environmental and worm samples can be valuable complements to fish testing.
DISEASES OF AQUATIC ORGANISMS
(2021)
Article
Chemistry, Multidisciplinary
Van A. Ortega, David Boyle, Jordan W. Hodgkinson, Denina B. D. Simmons, Miodrag Belosevic, James L. Stafford, Greg G. Goss
Summary: The study found that goldfish exhibited inflammatory responses to injected PAA-TiO2 nanoparticles; there was significant titanium metal deposition in tissues; kidney and spleen tissues experienced damage and lipid peroxidation; immune effector functions of neutrophils were enhanced, and inflammatory-related genes in hematopoietic organs showed significant changes after PAA-TiO2 injection.
ENVIRONMENTAL SCIENCE-NANO
(2021)
Article
Fisheries
Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng
Summary: In this study, a PPAE gene called FmPPAE1 was cloned and analyzed in banana shrimp. FmPPAE1 plays a vital role in regulating the proPO system, exhibits antibacterial properties, and contributes to the suppression of bacterial proliferation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun
Summary: Circular RNAs (circRNA) are involved in gene expression and affect cellular processes such as transcription, splicing, and translation by interacting with microRNA and RNA binding proteins. A study identified circDNAJB6 as a circular RNA abundant in chicken macrophages after bacterial infection, and found that circDNAJB6 exacerbates cellular injury and interacts with multiple miRNAs and target genes, potentially impacting autophagy and MAPK signaling pathways.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Summary: Chickens have a unique immune structure characterized by the absence of draining lymph nodes and the presence of well-developed mucosa-associated lymphoid tissue. The structure and development of chicken lymphoid tissues in the intestine, particularly Peyer's patches, have been poorly studied. However, the use of CSF1R-eGFP reporter transgenic chickens has allowed for the visualization and investigation of the development and distribution of these tissues. This research provides insights that could benefit mucosal vaccination strategies and the development of targeted vaccine delivery systems.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Retraction
Fisheries
G. -g. Li, Z. -z. Guo, X. -f. Ma, N. Cao, S. -n. Geng, Y. -q. Zheng, M. -j. Meng, H. -h. Lin, G. Han, G. -j. Du
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jinyue Yang, Peng Zhou, Wanrong Wu, Qingxiang Zhang, Dong Chen, Rui Luo
Summary: This study cloned and characterized the full-length sequence of duck MRE11 (duMRE11) for the first time, and found that this protein plays an important role in the innate immune response of ducks.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Yinan Li, Xingye Lian, Wenwen Yang, Jinyuan Leng, Jiejie Sun, Yu Liu, Siqi Fan, Lingling Wang, Linsheng Song
Summary: The DM9-containing protein CgDM9CP-7 plays an important role in the innate immune response of molluscs. It is constitutively expressed in various tissues and is up-regulated in haemocytes after stimulation by Vibrio splendidus and lipopolysaccharide (LPS). CgDM9CP-7 binds to various pathogens and exhibits antimicrobial activity, while also regulating the expression of CgMyD88 and CgIL-17.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Xiuwen Bao, Haoran Song, Liying He, Yong Li, Shuqi Niu, Jinlin Guo
Summary: This study focuses on the interaction between Hepialus xiaojinensis larvae and Ophiocordyceps sinensis during the infection process. The results show that the infected third instar larvae enhance antioxidant defense ability, while the infected fourth instar larvae reduce this ability and allocate more energy to growth and development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)