Cdk5 regulates multiple cellular events in neural development, function and disease

Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration

(2014) A. Louvi et al.   DEVELOPMENT

Memory Enhancement by Targeting Cdk5 Regulation of NR2B

(2014) Florian Plattner et al.   NEURON

Cdk5 Phosphorylates Dopamine D2 Receptor and Attenuates Downstream Signaling

(2014) Jaehoon Jeong et al.   PLoS One

Phosphorylation of Drebrin by Cyclin-Dependent Kinase 5 and Its Role in Neuronal Migration

(2014) Kazuya Tanabe et al.   PLoS One

Searching for Novel Cdk5 Substrates in Brain by Comparative Phosphoproteomics of Wild Type and Cdk5−/− Mice

(2014) Erick Contreras-Vallejos et al.   PLoS One

Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum

(2014) Yusuke Seto et al.   Nature Communications

Extra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disorders

(2013) Takeshi Kawauchi et al.   GENES TO CELLS

Drebrin contains a cryptic F-actin–bundling activity regulated by Cdk5 phosphorylation

(2013) Daniel C. Worth et al.   JOURNAL OF CELL BIOLOGY

Forebrain-specific deletion of Cdk5 in pyramidal neurons results in mania-like behavior and cognitive impairment

(2013) Susan C. Su et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Axin Directs the Amplification and Differentiation of Intermediate Progenitors in the Developing Cerebral Cortex

(2013) Wei-Qun Fang et al.   NEURON

Tethering the assembly of SNARE complexes

(2013) WanJin Hong et al.   TRENDS IN CELL BIOLOGY

Deregulated Cdk5 Activity Is Involved in Inducing Alzheimer’s Disease

(2012) Varsha Shukla et al.   ARCHIVES OF MEDICAL RESEARCH

Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation

(2012) Kensaku Mizuno   CELLULAR SIGNALLING

Neuronal subtype specification in the cerebellum and dorsal hindbrain

(2012) Mikio Hoshino   DEVELOPMENT GROWTH & DIFFERENTIATION

Formation of Axon-dendrite polarity in situ: Initiation of axons from polarized and non-polarized cells

(2012) Yumiko Hatanaka et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

p27Kip1 Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration

(2012) Juliette D. Godin et al.   DEVELOPMENTAL CELL

Cell Adhesion and Its Endocytic Regulation in Cell Migration during Neural Development and Cancer Metastasis

(2012) Takeshi Kawauchi   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LMTK1/AATYK1 Is a Novel Regulator of Axonal Outgrowth That Acts via Rab11 in a Cdk5-Dependent Manner

(2012) T. Takano et al.   JOURNAL OF NEUROSCIENCE

Cyclin-dependent kinase 5 is required for normal cerebellar development

(2012) A. Kumazawa et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Differential roles of cyclin-dependent kinase 5 in tangential and radial migration of cerebellar granule cells

(2012) Hiroki Umeshima et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory

(2012) Kwok-On Lai et al.   NATURE NEUROSCIENCE

A Preferentially Segregated Recycling Vesicle Pool of Limited Size Supports Neurotransmission in Native Central Synapses

(2012) Vincenzo Marra et al.   NEURON

Regulation of N-type Voltage-Gated Calcium Channels and Presynaptic Function by Cyclin-Dependent Kinase 5

(2012) Susan C. Su et al.   NEURON

Reelin Controls Neuronal Positioning by Promoting Cell-Matrix Adhesion via Inside-Out Activation of Integrin α5β1

(2012) Katsutoshi Sekine et al.   NEURON

Cbln1 and its family proteins in synapse formation and maintenance

(2011) Michisuke Yuzaki   CURRENT OPINION IN NEUROBIOLOGY

Cyclin E Constrains Cdk5 Activity to Regulate Synaptic Plasticity and Memory Formation

(2011) Junko Odajima et al.   DEVELOPMENTAL CELL

Cdk5-Mediated Phosphorylation of Axin Directs Axon Formation during Cerebral Cortex Development

(2011) W.-Q. Fang et al.   JOURNAL OF NEUROSCIENCE

The Outermost Region of the Developing Cortical Plate Is Crucial for Both the Switch of the Radial Migration Mode and the Dab1-Dependent "Inside-Out" Lamination in the Neocortex

(2011) K. Sekine et al.   JOURNAL OF NEUROSCIENCE

Nestin negatively regulates postsynaptic differentiation of the neuromuscular synapse

(2011) Jiefei Yang et al.   NATURE NEUROSCIENCE

Cdk5: a multifaceted kinase in neurodegenerative diseases

(2011) Zelda H. Cheung et al.   TRENDS IN CELL BIOLOGY

The neuronal p35 activator of Cdk5 is a novel F-actin binding and bundling protein

(2010) Lisheng He et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The role of Rho GTPase proteins in CNS neuronal migration

(2010) Eve-Ellen Govek et al.   Developmental Neurobiology

Cdk5 Suppresses the Neuronal Cell Cycle by Disrupting the E2F1-DP1 Complex

(2010) J. Zhang et al.   JOURNAL OF NEUROSCIENCE

S-Nitrosylation of Cyclin-Dependent Kinase 5 (Cdk5) Regulates Its Kinase Activity and Dendrite Growth During Neuronal Development

(2010) P. Zhang et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of p27Kip1 at Thr187 by Cyclin-dependent Kinase 5 Modulates Neural Stem Cell Differentiation

(2010) Ya-Li Zheng et al.   MOLECULAR BIOLOGY OF THE CELL

The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death

(2010) En Huang et al.   NATURE CELL BIOLOGY

Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum

(2010) Takaki Miyata et al.   Neural Development

Dixdc1 Is a Critical Regulator of DISC1 and Embryonic Cortical Development

(2010) Karun K. Singh et al.   NEURON

CDK5 Serves as a Major Control Point in Neurotransmitter Release

(2010) Sung Hyun Kim et al.   NEURON

Rab GTPases-Dependent Endocytic Pathways Regulate Neuronal Migration and Maturation through N-Cadherin Trafficking

(2010) Takeshi Kawauchi et al.   NEURON

Guiding Neuronal Cell Migrations

(2010) O. Marin et al.   Cold Spring Harbor Perspectives in Biology

Dissecting the Factors Involved in the Locomotion Mode of Neuronal Migration in the Developing Cerebral Cortex

(2009) Yoshiaki V. Nishimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclin I activates Cdk5 and regulates expression of Bcl-2 and Bcl-XL in postmitotic mouse cells

(2009) Paul T. Brinkkoetter et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death

(2009) Bo Tian et al.   NATURE CELL BIOLOGY

Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration

(2009) Cai Huang et al.   NATURE CELL BIOLOGY

Synaptic AMPA Receptor Plasticity and Behavior

(2009) Helmut W. Kessels et al.   NEURON

Cortical Interneurons Require p35/Cdk5 for their Migration and Laminar Organization

(2008) Sonja Rakić et al.   CEREBRAL CORTEX

LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein

(2008) Masami Yamada et al.   EMBO JOURNAL

CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5

(2008) Shuyong Lin et al.   FEBS LETTERS

Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 complexes

(2008) Akiko Asada et al.   JOURNAL OF NEUROCHEMISTRY

Suppression of Mutant Huntingtin Aggregate Formation by Cdk5/p35 through the Effect on Microtubule Stability

(2008) S. Kaminosono et al.   JOURNAL OF NEUROSCIENCE

Cdk5 Regulates the Phosphorylation of Tyrosine 1472 NR2B and the Surface Expression of NMDA Receptors

(2008) S. Zhang et al.   JOURNAL OF NEUROSCIENCE

Interplay between Cyclin-Dependent Kinase 5 and Glycogen Synthase Kinase 3  Mediated by Neuregulin Signaling Leads to Differential Effects on Tau Phosphorylation and Amyloid Precursor Protein Processing

(2008) Y. Wen et al.   JOURNAL OF NEUROSCIENCE

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

(2008) Dohoon Kim et al.   NEURON