Journal
DEVELOPMENT GROWTH & DIFFERENTIATION
Volume 56, Issue 5, Pages 368-375Publisher
WILEY-BLACKWELL
DOI: 10.1111/dgd.12139
Keywords
cell death; compensatory proliferation; Drosophila; imaginal disc; regeneration
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Funding
- Japanese Ministry of Education, Science, Sports, Culture, and Technology
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Regeneration is a fascinating process that allows some organisms to reconstruct damaged tissues. In addition to the classical regeneration model of the Drosophila larval imaginal discs, the genetically induced tissue ablation model has promoted the understanding of molecular mechanisms underlying cell death, proliferation, and remodeling for tissue regeneration. Recent studies have also revealed that tissue injury responses occur not only locally but also systemically, even in the uninjured region. Genetic studies in Drosophila have demonstrated the dynamic role of the cell death-induced tissue response in the reconstruction of damaged tissues.
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