Article
Cell Biology
Ai Jiang, Peng Xu, Shang Sun, Zhenda Zhao, Qizhao Tan, Weishi Li, Chunli Song, Huijie Leng
Summary: Osteoarthritis is a joint disorder characterized by cartilage degeneration and bone sclerosis. Cellular phenotypic changes in chondrocytes and bone cells, as well as aberrant intercellular communications, play important roles in the development of OA. Understanding these changes and mechanisms may lead to the development of targeted drugs with fewer side effects.
CONNECTIVE TISSUE RESEARCH
(2021)
Review
Endocrinology & Metabolism
Di Zhang, Jinhua Xue, Fang Peng
Summary: Long non-coding RNA MALAT1 is involved in the development of bone and cartilage diseases, and has potential implications in clinical diagnosis and drug development.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Haowen Yin, Hao Yue, Meng Wang, Tianqi Zhang, Yun-Tao Zhao, Hongying Liu, Jingfeng Wang, Hongwei Zheng, Changhu Xue
Summary: Hypertrophic chondrocytes play a key role in fracture healing, and sea cucumber intestinal peptide (SCIP) has been found to promote differentiation of hypertrophic chondrocytes to the osteoblast lineage, thus promoting tibial fracture healing in mice. SCIP may have potential as a raw material for developing nutraceuticals to enhance fracture healing.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Krisztina Nikovics, Cedric Castellarin, Xavier Holy, Marjorie Durand, Halima Morin, Abdelhafid Bendahmane, Anne-Laure Favier
Summary: Understanding bone homeostasis and regeneration is of great clinical and scientific importance for the development of bone therapy. Macrophages play a crucial role in bone regeneration during healing. In situ hybridization and hybridization chain reaction can be used to explore gene expression in bone tissues.
Article
Cell Biology
Rong Li, Zijing Guan, Shuyan Bi, Fanhua Wang, Liang He, Xin Niu, Yu You, Yuwei Liu, Yi Ding, Stefan Siwko, Ning Wang, Ziming Zhang, Yunyun Jin, Jian Luo
Summary: This study reveals that proton-activated GPR4 plays a crucial role in the development of osteoarthritis (OA). Overexpression of GPR4 accelerates OA progression in mouse joints, while Gpr4 knockout effectively attenuates posttraumatic and aging-associated OA. Inhibition of GPR4 with the antagonist NE52-QQ57 ameliorates OA progression, promotes extracellular matrix (ECM) production, and protects cartilage from degradation. These findings suggest that GPR4 could be a promising therapeutic target for OA treatment.
CELL DEATH & DISEASE
(2022)
Article
Endocrinology & Metabolism
Mohammed A. Alharbi, Dana T. Graves
Summary: Diabetes mellitus is associated with higher risks of fractures and delayed bone healing. FOXO1 plays a key role in diabetes-impaired angiogenesis and chondrocyte apoptosis. This study found that diabetic mice had fewer blood vessels and increased chondrocyte apoptosis, while FOXO1 deletion partially rescued these effects.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biology
Shawn A. Hallett, Wanida Ono, Yuki Matsushita, Naoko Sakagami, Koji Mizuhashi, Nicha Tokavanich, Mizuki Nagata, Annabelle Zhou, Takao Hirai, Henry M. Kronenberg, Noriaki Ono
Summary: In the resting zone of the postnatal growth plate, chondrocytes with slow cell cycle progression are maintained in a Wnt-inhibitory environment. This study uncovered a novel mechanism regulating the maintenance and differentiation of PTHrP(+) skeletal stem cells, highlighting the role of Wnt signaling in this process.
Article
Biochemistry & Molecular Biology
Lena Steppe, Jasmin Buelow, Jan Tuckermann, Anita Ignatius, Melanie Haffner-Luntzer
Summary: The deletion of ER alpha gene in osteoblast progenitors and hypertrophic chondrocytes has differential effects on bone mass regulation in male and female mice. Male mice showed increased cortical bone mass and femur rigidity, while female mice exhibited trabecular bone loss and reduced cortical bone diameters. This study improves understanding of ER alpha signaling in bone cells in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yueyi Yang, Demao Zhang, Daimo Guo, Jiachi Li, Siqun Xu, Jieya Wei, Jing Xie, Xuedong Zhou
Summary: This study found that communication with osteoblasts reduces cholesterol synthesis in chondrocytes through Notch1 signaling. Specifically, osteoblasts decreased cholesterol synthesis in chondrocytes by reducing the expression of a series of synthetases, potentially impacting cellular lipid metabolism.
CELL PROLIFERATION
(2021)
Article
Engineering, Biomedical
Gagan K. Jalandhra, Thomas G. Molley, Tzong-tyng Hung, Iman Roohani, Kristopher A. Kilian
Summary: This study developed a unique printing platform that integrates soft and hard materials concurrently through freeform printing of mineralized constructs within tunable micro-gel suspensions containing living cells. By tuning the microgel stiffness and filler content, chondrogenesis and osteogenesis can be differentially directed within the same construct, enabling the fabrication of osteochondral interfaces in a single step. This versatile one-pot biofabrication approach has the potential to aid in bone disease modeling and tissue engineering.
ACTA BIOMATERIALIA
(2023)
Article
Pharmacology & Pharmacy
Tian Fujun, Sun Jiabao, Yue Jianmin, Wang Qiyu
Summary: This study evaluated the toxicological effects of HBCD on chondrocytes and cartilaginous tissue. The results showed that HBCD reduces the proliferative capacity of chondrocytes and induces cell death, as well as causing an inflammatory response. The study also found that HBCD activates the DAMP sensor NLRP3, which mediates chondrocyte PANoptosis.
Article
Biology
Jason T. Long, Abigail Leinroth, Yihan Liao, Yinshi Ren, Anthony J. Mirando, Tuyet Nguyen, Wendi Guo, Deepika Sharma, Douglas Rouse, Colleen Wu, Kathryn Song Eng Cheah, Courtney M. Karner, Matthew J. Hilton
Summary: The study reveals that hypertrophic chondrocytes undergo dedifferentiation to give rise to marrow-associated skeletal stem and progenitor cells (SSPCs), which serve as a primary source of osteoblasts during skeletal development and also contribute to the adipogenic lineage.
Article
Dentistry, Oral Surgery & Medicine
C. Tsutsumi-Arai, Y. Arai, A. Tran, M. Salinas, Y. Nakai, S. Orikasa, W. Ono, N. Ono
Summary: The mandibular condylar cartilage (MCC) plays a crucial role in the vertical growth of the mandibular ramus. In this study, researchers investigated the role of parathyroid hormone-related protein (PTHrP) in MCC chondrogenesis. They found that PTHrP released from cells in the superficial layer directly promotes proliferation of chondrocyte precursor cells and prevents their premature differentiation. This study uncovers a unique mechanism by which PTHrP regulates MCC chondrogenesis.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Immunology
Zhiqin Deng, Qian Zhang, Zhe Zhao, Yongshen Li, Xiaoqiang Chen, Zicong Lin, Zhenhan Deng, Jianquan Liu, Li Duan, Daping Wang, Wencui Li
Summary: Osteoimmunology studies the interactions between the immune system and the skeletal system, with different immune cells playing various roles in regulating osteoclasts and chondrocytes. These cells maintain a dynamic balance through multiple signaling mechanisms.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Luca Dalle Carbonare, Jessica Bertacco, Giulia Marchetto, Samuele Cheri, Michela Deiana, Arianna Minoia, Natascia Tiso, Monica Mottes, Maria Teresa Valenti
Summary: The study investigated the effects of MSM on chondrogenesis and osteogenesis, showing that MSM promotes chondrogenesis and preosteoblast formation. It suggests that MSM could be a useful tool to counteract skeletal degenerative diseases.
STEM CELL RESEARCH & THERAPY
(2021)
