Enpp1 inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling

Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation

(2015) P. Andre et al.   DEVELOPMENT

Dual pathways to endochondral osteoblasts: a novel chondrocyte-derived osteoprogenitor cell identified in hypertrophic cartilage

(2015) J. Park et al.   Biology Open

Mono-allelic and bi-allelic ENPP1 deficiency promote post-injury neointimal hyperplasia associated with increased C/EBP homologous protein expression

(2014) Ramon L. Serrano et al.   ATHEROSCLEROSIS

Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1−/− mice

(2014) Mark O.R. Hajjawi et al.   BONE

Regulation of the Catabolic Cascade in Osteoarthritis by the Zinc-ZIP8-MTF1 Axis

(2014) Jin-Hong Kim et al.   CELL

Osteogenic fate of hypertrophic chondrocytes

(2014) Guan Yang et al.   CELL RESEARCH

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma

(2014) Xuelian He et al.   NATURE MEDICINE

Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation

(2014) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

(2014) Xin Zhou et al.   PLoS Genetics

Mutant Enpp1asj mice as a model for generalized arterial calcification of infancy

(2013) Q. Li et al.   Disease Models & Mechanisms

Nonhydrolyzable ATP Analogues as Selective Inhibitors of Human NPP1: A Combined Computational/Experimental Study

(2013) Joanna Lecka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification

(2013) Jean B Regard et al.   NATURE MEDICINE

Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice

(2012) J Bertrand et al.   ANNALS OF THE RHEUMATIC DISEASES

Biomechanical factors in osteoarthritis

(2012) Farshid Guilak   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Purines, Purinergic Receptors, and Cancer

(2012) F. Di Virgilio   CANCER RESEARCH

Sox9 Directs Hypertrophic Maturation and Blocks Osteoblast Differentiation of Growth Plate Chondrocytes

(2012) Peter Dy et al.   DEVELOPMENTAL CELL

Hand osteoarthritis: New insights

(2012) Odile Gabay et al.   JOINT BONE SPINE

Dimerization and Cytoplasmic Localization Regulate Hippo Kinase Signaling Activity in Organ Size Control

(2012) Yunyun Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generalized arterial calcification of infancy and pseudoxanthoma elasticum: two sides of the same coin

(2012) Yvonne Nitschke et al.   Frontiers in Genetics

Generalized Arterial Calcification of Infancy and Pseudoxanthoma Elasticum Can Be Caused by Mutations in Either ENPP1 or ABCC6

(2011) Yvonne Nitschke et al.   AMERICAN JOURNAL OF HUMAN GENETICS

RNAscope

(2011) Fay Wang et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Wnt/ -catenin signaling is differentially regulated by G  proteins and contributes to fibrous dysplasia

(2011) J. B. Regard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss-of-Function ENPP1 Mutations Cause Both Generalized Arterial Calcification of Infancy and Autosomal-Recessive Hypophosphatemic Rickets

(2010) Bettina Lorenz-Depiereux et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

The role of the cartilage matrix in osteoarthritis

(2010) Dick Heinegård et al.   Nature Reviews Rheumatology

The bone–cartilage unit in osteoarthritis

(2010) Rik J. Lories et al.   Nature Reviews Rheumatology

Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders

(2010) Rita Dreier   ARTHRITIS RESEARCH & THERAPY

The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization

(2009) K. S. Joeng et al.   DEVELOPMENT

New Variants in theEnpp1andPtpn6Genes Cause Low BMD, Crystal-Related Arthropathy, and Vascular Calcification

(2009) Philip Babij et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

(2009) Alvin C Lin et al.   NATURE MEDICINE

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy

(2008) K. K. Mak et al.   DEVELOPMENT

Hedgehog Signaling in Mature Osteoblasts Regulates Bone Formation and Resorption by Controlling PTHrP and RANKL Expression

(2008) Kinglun Kingston Mak et al.   DEVELOPMENTAL CELL

The additive effect of individual genes in predicting risk of knee osteoarthritis

(2007) A M Valdes et al.   ANNALS OF THE RHEUMATIC DISEASES