Article
Endocrinology & Metabolism
Yue Xi, Dan Zhang, Yue Liang, Zhongyan Shan, Xiaochun Teng, Weiping Teng
Summary: Thyroid hormone plays a critical role in the development of vertebrates and affects the function of various organs, especially the intestine. This study identified differentially expressed proteins in the distal ileum of homozygous Thra(E403X/E403X) and wild-type Thra(+/+) mice through proteomic analysis. The differentially expressed proteins are involved in metabolic and developmental processes, nutrient transport, and the intestinal immune system.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yue Liang, Defa Zhao, Ranran Wang, Pingping Dang, Yue Xi, Dan Zhang, Wei Wang, Zhongyan Shan, Xiaochun Teng, Weiping Teng
Summary: A mouse model carrying the Thra1(E403X) mutation found in human RTH alpha patients was generated, exhibiting clinical features similar to human RTH alpha, including neurological symptoms and thyroid function abnormalities. These findings provide a useful tool for studying the role of TR alpha 1 in development and determining the pathological mechanisms of RTH alpha.
Article
Engineering, Environmental
Jian Li, Ying Xu, Na Li, Rui Zuo, Yuanzheng Zhai, Haiyang Chen
Summary: Through integrated in vitro, in vivo, and in silico assays, the study investigated the thyroid hormone-disrupting effects and mechanisms of 8 typical organophosphate esters (OPEs). It was found that these chemicals competitively bound to the membrane thyroid hormone receptor (mTR) and some OPEs also interacted with the nuclear thyroid hormone receptor (nTR). Molecular docking simulation supported these findings. In addition, in vivo analyses using zebrafish embryo development demonstrated the thyroid hormone-disrupting effects of OPEs and their possible association with mTR.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Sunmi Park, Xuguang Zhu, Minjun Kim, Li Zhao, Sheue-Yann Cheng
Summary: Mutations of the THRA gene can cause defective B cell development, leading to B cell deficiency in RTH alpha patients. This is possibly due to the suppression of key regulators such as Ebf1, Tcf3, and Pax5 by TR alpha 1 mutants.
Review
Endocrinology & Metabolism
Limei Li, Yan Song, Yongquan Shi, Liangliang Sun
Summary: Nonalcoholic fatty liver disease (NAFLD) is a metabolic liver disease without a known cause or FDA-approved drug treatment. Hypothyroidism has been identified as a risk factor for NAFLD, as thyroid hormone (TH) is important for metabolism regulation in adults. Thyroxine, a synthetic TH, has been shown to reduce liver fat in animal models with NAFLD, but it has side effects, especially in the heart. To overcome these side effects, agonists specific to the TR beta, a subtype of the TH receptor mainly expressed in the liver, have been developed and shown positive therapeutic effects in NAFLD animal models and clinical trials. This review aims to provide an updated reference and explore the future therapeutic potential of TR beta-specific agonists in the treatment of NAFLD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Constanza Contreras-Jurado, Ana Montero-Pedrazuela, Raul F. Perez, Susana Alemany, Mario F. Fraga, Ana Aranda
Summary: This study found that triiodothyronine (T3), a thyroid hormone, enhances the reprogramming of mouse embryonic fibroblasts (MEFs) into induced pluripotent stem cells (iPSCs). T3-induced iPSCs show similar characteristics to embryonic stem cells and have the potential for differentiation into the three major germ layers. The inclusion of T3 in reprogramming strategies could be useful for studying cell plasticity, disease, and regenerative medicine.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Huei-Pin Lai, Mei-Hsiu Chen
Summary: This study reports a family with resistance to thyroid hormone (RTH) caused by a rare point mutation in the thyroid hormone receptor beta (THR beta) gene. The proband developed atrial fibrillation and life-threatening heart failure with pulmonary edema, which differs from previously reported mutations. This study contributes to a better understanding and management of patients with RTH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Gregory A. Brent
Summary: Thyroid hormone plays a vital role in development and has diverse effects on various tissues and organs in the body. Early markers of thyroid hormone action included oxygen consumption, basal metabolic rate, serum cholesterol, and deep tendon reflex time. Research has focused on understanding the nuclear and cellular mechanisms of thyroid hormone action, including the role of thyroid hormone receptors, coactivators, DNA response elements, and transportation defects.
Review
Pharmacology & Pharmacy
Qianyu Tang, Min Zeng, Linxi Chen, Nian Fu
Summary: This review discusses the role of the thyroid hormone/thyroid hormone receptor axis in liver diseases, including its beneficial effects on metabolic-associated fatty liver disease, hepatitis, liver fibrosis, and liver injury, as well as its detrimental effects on the progression of acute liver failure and alcoholic liver disease. Moreover, the TH/TR axis exhibits paradoxical roles in hepatocellular carcinoma.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lin Wang, Mei Guo, Guoli Feng, Pan Wang, Jie Xu, Jie Yu
Summary: Chronic exposure to nonylphenol at environmental concentration may have toxic effects on thyroid function and induce thyroid hyperplasia disease in male rats.
Article
Pharmacology & Pharmacy
Aimo Kannt, Paulus Wohlfart, Andreas Nygaard Madsen, Sanne Skovgard Veidal, Michael Feigh, Dieter Schmoll
Summary: The study demonstrated that treatment with resmetirom in DIO-NASH mice significantly improved hepatic metabolism and fibrosis levels, reflecting the benefits of THR-beta activation.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biophysics
Jayeon Song, Hansol Kim, Chang Yeol Lee, Junhyeok Yoon, Won Sang Yoo, Hyun Gyu Park
Summary: The novel method named Aptamer-assisted Protein-induced Fluorescence Enhancement (AptPIFE) successfully identifies the interaction between thyroid hormone and thyroid hormone receptor with high sensitivity and excellent specificity, proving practical and robust applicability by screening TR antagonists and quantifying thyroid hormone in clinical samples.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biochemistry & Molecular Biology
Sabine Heublein, Udo Jeschke, Cornelia Sattler, Christina Kuhn, Anna Hester, Bastian Czogalla, Fabian Trillsch, Sven Mahner, Doris Mayr, Elisa Schmoeckel, Nina Ditsch
Summary: The study investigated the subcellular localization of thyroid hormone receptors (TRs) in ovarian cancer (OC) and its association with patient prognosis. The results showed that cytoplasmatic localization of TR beta was linked to shorter overall survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yanis Zekri, Romain Guyot, Frederic Flamant
Summary: We have created a database that integrates RNA-seq and ChIP-seq data to better understand the target genes of thyroid hormone receptors in different cell types. This database serves as a resource for studying the mode of action of thyroid hormone and provides a user-friendly tool to access specific gene information and extract gene lists of interest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wesley Wang, Dolena Ledee
Summary: The study identified ACAA2 as a novel interacting protein with TRb1 in the heart, acting as a TH-dependent coactivator for TRb1, capable of binding to TR recognition sequences without altering TRb1's DNA binding ability. This discovery opens a new paradigm for understanding how TH/TRs may be manipulated by energetic pathway molecules.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medical Laboratory Technology
Christine Vignon, Sebastien Lachot, Amelie Foucault, Noemie Ravalet, Emmanuel Gyan, Frederic Picou, Beatrice Herault, Louis-Romee Le Nail, Marie C. Bene, Olivier Herault
CYTOMETRY PART B-CLINICAL CYTOMETRY
(2020)
Article
Multidisciplinary Sciences
Amelie Foucault, Nicolas Vallet, Noemie Ravalet, Frederic Picou, Marie C. Bene, Emmanuel Gyan, Olivier Herault
Summary: This study concludes that there is an adverse association between occupational pesticide exposure and acute myeloid leukemia, particularly with insecticides. Analysis of the data also indicates that this association is primarily influenced by specific study conditions and factors.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Noemie Ravalet, Amelie Foucault, Frederic Picou, Martin Gombert, Emmanuel Renoult, Julien Lejeune, Nicolas Vallet, Sebastien Lachot, Emmanuelle Rault, Emmanuel Gyan, Marie C. Bene, Olivier Herault
Summary: The study proposes the clinical use of unexploited research parameters for early detection of subclinical MDS by triggering blood smear examination. By identifying critical research parameters of white blood cells and calculating an MDS-likelihood score, early detection of MDS patients in the general population can be achieved through automated analysis on the DxH 800 hematology analyzer.
Article
Hematology
Amandine Pignarre, Fabrice Chatonnet, Gersende Caron, Marion Haas, Fabienne Desmots, Thierry Fest
Summary: The study identified two mechanisms driving human terminal B-cell differentiation, showing the downregulation of CD23 marker and IL-4 signaling in ASC-fated cells after initial IL-4 response, as well as the independent increase of IRF4 protein levels for ASC differentiation in CD23(-) cells. This provides new insights into the pathological mechanisms of lymphoma biology by characterizing the fate decision between activated B cells and plasmablasts.
Review
Immunology
Maud Lemarie, Fabrice Chatonnet, Gersende Caron, Thierry Fest
Summary: Antibody therapy, utilizing artificially-produced immunoglobulins, is an innovative and competitive field with potential for improvement in tissue targeting and antigen affinity. Understanding the cellular and molecular steps of B cell differentiation could enhance antibody therapy effectiveness, with a focus on unfolded protein response and endoplasmic reticulum stress in antibody production processes. Utilizing this knowledge may lead to increased productivity of therapeutic antibodies in industrial settings.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Marion Haas, Gersende Caron, Fabrice Chatonnet, Stephane Manenti, Elina Alaterre, Julie Devin, Celine Delaloy, Giulia Bertolin, Roselyne Viel, Amandine Pignarre, Francisco Llamas-Gutierrez, Anne Marchalot, Olivier Decaux, Karin Tarte, Laurent Delpy, Jerome Moreaux, Thierry Fest
Summary: The kinase PIM2 plays a crucial role in the differentiation of B cells and in the survival of mature normal and malignant plasma cells. PIM2 regulates the cell cycle and apoptotic processes, affecting the secretion ability and adaptability of plasma cells.
Article
Biotechnology & Applied Microbiology
Benjamin Roux, Frederic Picou, Christelle Debeissat, Myriam Koubi, Nathalie Gallay, Pierre Hirsch, Noemie Ravalet, Marie C. Bene, Michel Maigre, Mathilde Hunault, Jean Mosser, Amandine Etcheverry, Emmanuel Gyan, Francois Delhommeau, Jorge Domenech, Olivier Herault
Summary: DNA methylation plays a significant role in regulating hematologic malignancies, and the DNA methylation status of MSCs may contribute to the pathophysiology of these diseases. This study analyzed the modifications of DNA methylation profiles of MSCs induced by MDS or AML, and found global hypomethylation and aberrant methylation profiles in MDS and a subgroup of AML-MSCs, particularly in homeobox genes. These results suggest the importance of DNA methylation in MSCs in the development of hematologic malignancies.
CANCER GENE THERAPY
(2022)
Article
Immunology
Kathleen Santamaria, Fabienne Desmots, Simon Leonard, Gersende Caron, Marion Haas, Celine Delaloy, Fabrice Chatonnet, Delphine Rossille, Amandine Pignarre, Celine Monvoisin, Marine Seffals, Claire Lamaison, Michel Cogne, Karin Tarte, Thierry Fest
Summary: The expression of CD23 marker plays a crucial role in the differentiation of human LZ B-GC cells, as CD23 expression is restricted to the GC LZ. CD23-negative LZ B-GC cells can differentiate into plasmablasts, while cells expressing CD23 are unable to complete this differentiation process. Analysis indicates that the process of plasma cell differentiation involves a series of gene expression changes, including a transient MYC gene expression supporting B cell proliferation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Amelie Foucault, Noemie Ravalet, Joevin Besombes, Frederic Picou, Nathalie Gallay, Laetitia Babin, Jerome Bourgeais, Sophie Hamard, Jorge Domenech, Pascal Loyer, Nicolas Vallet, Julien Lejeune, Emmanuel Gyan, Marie C. Bene, Francois Vallette, Christophe Olivier, Olivier Herault
Summary: The exposure of normal bone marrow mesenchymal stem/stromal cells to low-dose pesticide mixture led to oxidative stress, senescence, accelerated aging, and increased sensitivity to oncogenic hits. This exposure also decreased ALDH2 activity, increased acetaldehyde levels and DNA damage, and altered the MSC's capacity to support primitive hematopoiesis. Similar abnormalities were observed in MSCs from patients with myelodysplastic syndrome, suggesting a role of pesticide-induced ALDH2 inhibition in the pathophysiology of this disease.
Letter
Oncology
Carmen Ruggiero, Barbara Altieri, Edith Arnold, Lourdes Siqueiros-Marquez, Mabrouka Doghman-Bouguerra, Mario Detomas, Nelly Durand, Marielle Jarjat, Max Kurlbaum, Fabrice Chatonnet, Timo Deutschbein, Carmen Clapp, Enzo Lalli
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Antoine Guillon, Deborah Brea-Diakite, Adeline Cezard, Alan Wacquiez, Thomas Baranek, Jerome Bourgeais, Frederic Picou, Virginie Vasseur, Lea Meyer, Christophe Chevalier, Adrien Auvet, Jose M. Carballido, Lydie Nadal Desbarats, Florent Dingli, Andrei Turtoi, Audrey Le Gouellec, Florence Fauvelle, Amelie Donchet, Thibaut Crepin, Pieter S. Hiemstra, Christophe Paget, Damarys Loew, Olivier Herault, Nadia Naffakh, Ronan Le Goffic, Mustapha Si-Tahar
Summary: Research has shown that influenza virus infection causes significant changes in lung metabolism, leading to the accumulation of succinate in respiratory fluids. Succinate exhibits powerful antiviral activity by inhibiting influenza virus replication and reducing metabolic disruptions and inflammatory responses. Administering succinate intranasally to mice reduces viral loads in the lungs and improves survival rates. The antiviral mechanism involves succinylation of viral nucleoproteins, which alters their interactions with viral RNA.
Article
Mathematical & Computational Biology
Marine Louarn, Fabrice Chatonnet, Xavier Garnier, Thierry Fest, Anne Siegel, Catherine Faron, Olivier Dameron
Summary: The study presents a modular RDF representation of the Regulatory Circuits called Linked Extended Regulatory Circuits (LERC), which allows fast and easy querying of the resources related to the dataset. LERC's flexible and modular architecture supports biologically-relevant SPARQL queries and facilitates reuse in other studies.
JOURNAL OF BIOMEDICAL SEMANTICS
(2022)
Article
Multidisciplinary Sciences
Emmanuel Gyan, Arnaud Pigneux, Mathilde Hunault, Pierre Peterlin, Martin Carre, Jacques-Olivier Bay, Caroline Bonmati, Maria-Pilar Gallego-Hernanz, Bruno Lioure, Philippe Bertrand, Nicolas Vallet, David Ternant, Francois Darrouzain, Frederic Picou, Marie-Christine Bene, Christian Recher, Olivier Herault
Summary: The study aimed to investigate the feasibility, safety, and efficacy of adding fish oil emulsion to the treatment regimen of AML patients. The results showed that the addition of FO did not improve the complete remission rate in high-risk AML patients, and no significant in vivo response in the Nrf2 pathway was observed.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Pascal Chappert, Francois Huetz, Marie-Alix Espinasse, Fabrice Chatonnet, Louise Pannetier, Lucie Da Silva, Clara Goetz, Jerome Megret, Aurelien Sokal, Etienne Crickx, Ivan Nemazanyy, Vincent Jung, Chiara Guerrera, Sebastien Storck, Matthieu Mahevas, Antonio Cosma, Patrick Revy, Thierry Fest, Claude-Agnes Reynaud, Jean-Claude Weill
Summary: This study identifies the mechanisms that contribute to the long-term survival of memory B cells, including early telomere elongation, affinity selection, and access to a specific niche.
Article
Cell & Tissue Engineering
Elia Henry, Frederic Picou, Vilma Barroca, Nathalie Dechamps, Steicy Sobrino, Emmanuelle Six, Camille Gobeaux, Patrick Auberger, Olivier Herault, Francoise Pflumio, Marie-Laure Arcangeli
Summary: In a steady state, hematopoietic stem cells (HSC) have low levels of reactive oxygen species (ROS). However, upon stress, HSC activate and their ROS levels increase, facilitating proliferation and differentiation. Antioxidants have been shown to maintain HSC self-renewal potential in various contexts, suggesting their potential use in culture-induced stress. This study demonstrates that the antioxidant Tempol can protect HSC functional properties during ex vivo culture, likely through VEGFa signaling.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)