Journal
DEVELOPMENT
Volume 139, Issue 12, Pages 2101-2106Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.078949
Keywords
Primordial germ cells; Cell migration; Epithelial to mesenchymal transition
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Funding
- National Institutes of Health [F32 GM 82169, R01 HD49100]
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Trans-epithelial migration describes the ability of migrating cells to cross epithelial tissues and occurs during development, infection, inflammation, immune surveillance, wound healing and cancer metastasis. Here we investigate Drosophila primordial germ cells (PGCs), which migrate through the endodermal epithelium. Through live imaging and genetic experimentation we demonstrate that PGCs take advantage of endodermal tissue remodeling to gain access to the gonadal mesoderm and are unable to migrate through intact epithelial tissues. These results are in contrast to the behavior of leukocytes, which actively loosen epithelial junctions to migrate, and raise the possibility that in other contexts in which migrating cells appear to breach tissue barriers, they are actually exploiting existing tissue permeability. Therefore, the use of active invasive programs is not the sole mechanism to infiltrate tissues.
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