Article
Biochemistry & Molecular Biology
Hee-Jin Kwak, Brenda I. Medina-Jimenez, Soon Cheol Park, Jung-Hyeuk Kim, Geon-Hwi Jeong, Mi-Jeong Jeon, Sangil Kim, Jung-Woong Kim, David A. Weisblat, Sung-Jin Cho
Summary: This study identified one slit gene and two robo genes in the leech, and found that they play important roles in neurogenesis, midline formation and eye spot development.
CELL AND BIOSCIENCE
(2023)
Article
Cell Biology
M. Constanza Gonzalez-Ramirez, Francisca Rojo-Cortes, Noemi Candia, Jorge Garay-Montecinos, Pablo Guzman-Palma, Jorge M. M. Campusano, Carlos Oliva
Summary: In this study, the role of the Slit-Robo3 signaling pathway in the morphogenesis of the Drosophila optic lobe was investigated. It was found that Slit and Robo3 are expressed in the same neuronal population and they regulate the compartmentalization of the optic lobe through an autocrine/paracrine mechanism. Furthermore, interactions with genes involved in endocytosis and actin dynamics were detected, indicating the involvement of the endocytic pathway and small GTPases in this process. This study reveals the important role of the Slit-Robo3 pathway in CNS development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Developmental Biology
Nikole R. Zuniga, Alexandre Dumoulin, Giuseppe Vaccaro, Esther T. Stoeckli
Summary: During neural circuit formation, the switch in receptor expression is crucial for axons to navigate from one intermediate target to the next. We identified Cables1 as a key linker that regulates receptor phosphorylation and controls axon navigation in the developing spinal cord.
Article
Cell Biology
Pablo Guzman-Palma, Esteban G. Contreras, Natalia Mora, Macarena Smith, M. Constanza Gonzalez-Ramirez, Jorge M. Campusano, Jimena Sierralta, Bassem A. Hassan, Carlos Oliva
Summary: The Slit-Robo pathway is involved in the development of motion sensitive neurons in the Drosophila visual system, regulating processes such as neuronal precursor migration, cell segregation, and connectivity pattern formation. This signaling pathway plays a versatile role in different developmental stages of a neural lineage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Emmanuelle Martinot, Derek Boerboom
Summary: Slit/Robo signaling pathway plays a crucial role in regulating steroidogenesis in Leydig cells of the testis, potentially mediating negative feedback on testosterone synthesis through an autocrine/paracrine mechanism.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Sreenivasulu Basha, Brady Jin-Smith, Chunbao Sun, Liya Pi
Summary: Liver fibrosis is a common consequence of chronic liver damage and can progress to cirrhosis and liver cancer. Recent research has identified signaling pathways, such as the SLIT/ROBO pathway, involved in tumor development and progression. SLIT and ROBO proteins play important roles in axon guidance and have been found to have emerging roles in liver fibrosis and cancer development. The expression patterns of these proteins in normal adult livers and different types of liver cancer have been examined, and their potential therapeutic implications have been reviewed for anti-fibrosis and anti-cancer drug development.
Review
Biochemistry & Molecular Biology
Lingyu Jiang, Jianxun Sun, Dingming Huang
Summary: Slit/Robo signaling has been found to play an important role in bone metabolism, regulating bone formation and resorption, and showing potential in treating metabolic bone diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Ivonne M. Sehring, Gilbert Weidinger
Summary: The development of vertebrate limbs and fins requires tissue growth directed away from the body. This study reveals the involvement of the Slit-Robo pathway, known for its function in axon guidance, in regulating the polarity of developing zebrafish fins. The study highlights an intricate signaling feedback between mesenchyme and the apical ectodermal ridge.
Article
Biochemistry & Molecular Biology
Jin-Soo Park, RyeonJin Cho, Eun-Young Kang, Yeon-Mok Oh
Summary: Research suggests that the protein Slit2 may be beneficial in treating emphysema by promoting regeneration of lung cells. Studies in mice show that Slit2 can increase cell proliferation and migration, leading to alveolar regeneration in a mouse model of emphysema. This signaling pathway could potentially be a target for developing new treatments for emphysema.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Harsha Mahabaleshwar, P. Asharani, Tricia Yi Loo, Shze Yung Koh, Melissa R. Pitman, Samuel Kwok, Jiajia Ma, Bo Hu, Fang Lin, Xue Li Lok, Stuart M. Pitson, Timothy E. Saunders, Tom J. Carney
Summary: Mesenchymal cell immigration into growing fins and limb buds drives distal outgrowth, with tensile forces between these cells essential for fin and limb morphogenesis. Morphogens derived from the apical fin domain regulate cell polarity, migration, division, and adhesion of limb mesenchyme cells. The mutant stomp in zebrafish displays defects in fin morphogenesis, including blister formation and loss of orientation and adhesion of immigrating fin mesenchyme cells. The gene encoding Slit3, an axon guidance ligand, is found to be mutated in stomp. Slit ligands derived from immigrating mesenchyme act via Robo receptors at the apical ectodermal ridge (AER) to promote the release of sphingosine-1-phosphate (S1P), which then diffuses back to the mesenchyme to regulate their polarization, orientation, positioning, and adhesion to the interstitial matrix of the fin fold.
Article
Neurosciences
Frances S. Hausmann, John M. Barrett, Megan E. Martin, Huiqing Zhan, Gordon M. G. Shepherd
Summary: This study used MAPseq to investigate the diversity of brainstem branching patterns of the pyramidal tract projections from the forelimb-related areas of the motor cortex. The results showed high yet systematic diversity in PT axons at the level of brainstem projection patterns. The projections from M1 and M2 were qualitatively similar, but with quantitative differences in subclasses and clusters.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Physiology
Li Feng, Hua-Pan Shu, Lu-Lu Sun, Yu-Chi Tu, Qian-Qian Liao, Li-Jun Yao
Summary: SLIT ligand and its receptor ROBO were initially recognized for their role in axon guidance in central nervous system development. In recent years, the role of the SLIT-ROBO signaling pathway has expanded to cell migration, tumor development, angiogenesis, and bone metabolism. This article reviews the advances in the study of the SLIT-ROBO pathway in various renal pathophysiological and kidney disorders and proposes new directions for further research in this field.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Wang Shu, Gan Wei-Dong, Jin Jin-Xiang, Shi Qing-Qing, Sui Cheng-Zhi
Summary: This article reviews the current research progress of the Slit-Robo signal transduction pathways, including protein structure, proteolytic processing, and various physiological processes. However, the highly diverse physiological processes of Slit-Robo require further study.
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Clinical Neurology
Quan Wen, Huandi Weng, Tao Liu, Lingtai Yu, Tainyun Zhao, Jingwen Qin, Si Li, Qingfeng Wu, Tissir Fadel, Yibo Qu, Libing Zhou
Summary: Understanding the role of Celsr2 in axon regeneration is crucial for neural repair. Previous studies have shown that Celsr2 plays critical roles in neural development, including cilia organization, neuron migration, and axon navigation. This study demonstrates that Celsr2 negatively regulates motor axon regeneration and its downregulation promotes axon regeneration and growth. The findings suggest that Celsr2 could be a potential target for improving neural repair.
Article
Cardiac & Cardiovascular Systems
Juanjuan Zhao, Susann Bruche, Helen G. Potts, Benjamin Davies, Mathilda T. M. Mommersteeg
Summary: This study investigates the impact of SLIT and ROBO gene deletions on heart development in mice. The findings reveal the crucial interactions between SLIT and ROBO in specific tissues, providing important insights into the heart defects caused by ROBO1 and ROBO4 mutations.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Carlos A. Diaz-Balzac, Maisha Rahman, Maria I. Lazaro-Pena, Lourdes A. Martin Hernandez, Yehuda Salzberg, Cristina Aguirre-Chen, Zaven Kaprielian, Hannes E. Bulow
Article
Developmental Biology
Brielle Bjorke, Farnaz Shoja-Taheri, Minkyung Kim, G. Eric Robinson, Tatiana Fontelonga, Kyung-Tai Kim, Mi-Ryoung Song, Grant S. Mastick
NEURAL DEVELOPMENT
(2016)
Review
Cell Biology
Minkyung Kim, Brielle Bjorke, Grant S. Mastick
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2019)
Article
Anatomy & Morphology
Juan A. Moreno-Bravo, Jesus E. Martinez-Lopez, M. Pilar Madrigal, Minkyung Kim, Grant S. Mastick, Guillermina Lopez-Bendito, Salvador Martinez, Eduardo Puelles
BRAIN STRUCTURE & FUNCTION
(2016)
Article
Cell Biology
Loic Fort, Jose Miguel Batista, Peter A. Thomason, Heather J. Spence, Jamie A. Whitelaw, Luke Tweedy, Jennifer Greaves, Kirsty J. Martin, Kurt I. Anderson, Peter Brown, Sergio Lilla, Matthew P. Neilson, Petra Tafelmeyer, Sara Zanivan, Shehab Ismail, David M. Bryant, Nicholas C. O. Tomkinson, Luke H. Chamberlain, Grant S. Mastick, Robert H. Insall, Laura M. Machesky
NATURE CELL BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Kyung-Tai Kim, Namhee Kim, Hwan-Ki Kim, Hojae Lee, Hannah N. Gruner, Peter Gergics, Chungoo Park, Grant S. Mastick, Hae-Chul Park, Mi-Ryoung Song
SCIENTIFIC REPORTS
(2016)
Article
Anatomy & Morphology
Claudia M. Garcia-Pena, Daniela Avila-Gonzalez, Amaya Miquelajauregui, Carlos Lozano-Flores, Grant S. Mastick, Elisa Tamariz, Alfredo Varela-Echavarria
FRONTIERS IN NEUROANATOMY
(2018)
Article
Neurosciences
Hannah N. Gruner, Minkyung Kim, Grant S. Mastick
Article
Developmental Biology
Minkyung Kim, Clare H. Lee, Sarah J. Barnum, Roland Cj Watson, Jennifer Li, Grant S. Mastick
DEVELOPMENTAL BIOLOGY
(2019)
Review
Neurosciences
Jessie L. St Martin, Lina Wang, Zaven Kaprielian
NEUROSCIENCE LETTERS
(2020)
Article
Biochemistry & Molecular Biology
Bongmin Bae, Hannah N. Gruner, Maebh Lynch, Ting Feng, Kevin So, Daniel Oliver, Grant S. Mastick, Wei Yan, Simon Pieraut, Pedro Miura
Article
Developmental Biology
Riley Kellermeyer, Leah M. Heydman, Taylor Gillis, Grant S. Mastick, Minmin Song, Thomas Kidd
Article
Developmental Biology
Brielle Bjorke, Katherine G. Weller, Lauren E. Jones, G. Eric Robinson, Michelle Vesser, Lisheng Chen, Philip J. Gage, Thomas W. Gould, Grant S. Mastick
Summary: Muscle function relies on correct innervation by motor nerves, which pause and branch as they approach muscle targets. The study of the oculomotor nerve in mouse embryos found that Pitx2 function and Myf5-expressing cells play crucial roles in nerve growth pause and muscle precursor development, respectively.
DEVELOPMENTAL BIOLOGY
(2021)
Review
Developmental Biology
Riley Kellermeyer, Leah M. Heydman, Grant S. Mastick, Thomas Kidd
JOURNAL OF DEVELOPMENTAL BIOLOGY
(2018)
Article
Developmental Biology
Minkyung Kim, Tatiana M. Fontelonga, Clare H. Lee, Sarah J. Barnum, Grant S. Mastick
DEVELOPMENTAL BIOLOGY
(2017)