Journal
DEVELOPMENT
Volume 135, Issue 8, Pages 1463-1470Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.017624
Keywords
Six2; Hoxa2; branchial arch; mouse
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Funding
- NCI NIH HHS [CA-21765] Funding Source: Medline
- NIDDK NIH HHS [R21DK068560] Funding Source: Medline
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Hox transcription factors control morphogenesis along the head-tail axis of bilaterians. Because their direct functional targets are still poorly understood in vertebrates, it remains unclear how the positional information encoded by Hox genes is translated into morphogenetic changes. Here, we conclusively demonstrate that Six2 is a direct downstream target of Hoxa2 in vivo and show that the ectopic expression of Six2, observed in the absence of Hoxa2, contributes to the Hoxa2 mouse mutant phenotype. We propose that Six2 acts to mediate Hoxa2 control over the insulin-like growth factor pathway during branchial arch development.
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