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Biochemistry & Molecular Biology
Yunlin He, Xingxing Zhu, Kaixuan Wang, Jikui Xie, Zehua Zhu, Ming Ni, Shicun Wang, Qiang Xie
Summary: This study developed a novel PET radiotracer for detecting A/3 plaques in Alzheimer's disease using the SuFEx method. The radiotracer showed high affinity for A/3 in in vitro and in vivo experiments. It could penetrate the blood-brain barrier and had a high initial brain uptake and fast washout. In vitro autoradiography further confirmed its affinity for A/3 plaques in AD human brain tissues.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
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Radiology, Nuclear Medicine & Medical Imaging
Tetsuro Tago, Jun Toyohara, Ryo Fujimaki, Maho Tatsuta, Ruichong Song, Keiichi Hirano, Kumiko Iwai, Hiroshi Tanaka
Summary: The use of F-18-labelled neopentyl glycol side-chain affects the characteristics of brain imaging agents, resulting in aminostilbene compounds demonstrating preferable pharmacokinetic properties.
NUCLEAR MEDICINE AND BIOLOGY
(2021)
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Chemistry, Multidisciplinary
Marija Baranac-Stojanovic
CHEMISTRY-AN ASIAN JOURNAL
(2018)
Article
Chemistry, Multidisciplinary
Jovana Aleksic, Milovan Stojanovic, Marija Baranac-Stojanovic
CHEMISTRY-AN ASIAN JOURNAL
(2018)
Article
Chemistry, Multidisciplinary
Milovan Stojanovic, Marija Baranac-Stojanovic
NEW JOURNAL OF CHEMISTRY
(2018)
Article
Chemistry, Organic
Milovan Stojanovic, Marija Baranac-Stojanovic
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Marija Baranac-Stojanovic
CHEMISTRY-A EUROPEAN JOURNAL
(2019)
Article
Chemistry, Organic
Marija Baranac-Stojanovic
JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Chemistry, Organic
Marija Baranac-Stojanovic
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Organic
Milovan Stojanovic, Slobodan Bugarski, Marija Baranac-Stojanovic
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Marija Baranac-Stojanovic, Milovan Stojanovic, Jovana Aleksic
Summary: By employing density functional theory calculations, this study investigates the effect of silicon substitution on the aromaticity of polycyclic aromatic hydrocarbons. The results show that the placement of silicon atoms can tune the singlet-triplet energy gaps and regulate the extent of global, semiglobal, and local aromaticity. This work extends the importance of Huckel aromaticity to excited triplet states.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Organic
Jovana Aleksic, Milovan Stojanovic, Marija Baranac-Stojanovic
Summary: Aromaticity rules in the ground singlet state and the first excited triplet state are opposite. Calculations using quantum-mechanical methods reveal the (anti)aromaticity of corannulene dianions and diacations in their different states and structures. Results show that singlet dianions have an aromatic hub and antiaromatic rim, while singlet diacations are antiaromatic. Triplet dianions exhibit an aromatic rim and nonaromatic hub, while triplet diacations are nonaromatic.
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Jovana Aleksic, Milovan Stojanovic, Jaksa Boskovic, Marija Baranac-Stojanovic
Summary: We developed a green and atom-economical method using solid-state silica gel catalysis for the synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines, and ethyl propiolate. By heating the reactants and silica gel in a closed vessel, the DHP skeleton was assembled. Aliphatic amines predominantly produced 1,4-isomers of DHPs, while reactions with aromatic amines yielded a mixture of 1,4- and 1,2-isomers. Addition of 1% mass percent of H2SO4 to silica gel shifted the product distribution towards 1,4-DHPs.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Organic
Marija Baranac-Stojanovic, Jovana Aleksic, Milovan Stojanovic
Summary: Computational investigation confirms the prevalence of lactim in the gas-phase tautomerism of 2- and 4-pyridones. Aromaticity gain is greater in the tautomerization of 4-pyridone, driven by Pauli repulsion relief. In contrast, orbital and electrostatic interactions favor lactim in 2-pyridone. The position of tautomeric equilibrium can be controlled by substituents and medium polarity.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Marija Baranac-Stojanovic, Milovan Stojanovic, Jovana Aleksic
Summary: The study investigates the aromaticity-antiaromaticity switch during the singlet-triplet transition of important monoheterocycles derived from benzene, naphthalene, and anthracene. It was found that spin delocalization leads to antiaromaticity, while spin density localization on a ring or heteroatom reduces global and local antiaromaticity. Silicon-containing compounds exhibit the lowest singlet-triplet energy gaps.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Physical
Marija Baranac-Stojanovic, Milovan Stojanovic
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2019)
Article
Chemistry, Physical
Marija Baranac-Stojanovic, Milovan Stojanovic
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2019)