4.7 Article

Palladium(II)-Catalyzed Formal [3+2] Cycloaddition of Aziridines with 3-Substituted Indoles: Synthesis of Enantioenriched Pyrroloindolines

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 80, Issue 21, Pages 10710-10718

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b01931

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Funding

  1. National Basic Research Program of China (973 Program) [2010CB833200]
  2. National Natural Science Foundation of China [21272247, 21290184]

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A Pd-catalyzed enantiospecific formal [3 + 2] cycloaddition between chiral aziridines and indoles has been developed. With this method, chiral pyrroloindolines in enantiomerically pure forms were constructed in high yields and diastereoselectivities under mild conditions.

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