Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 80, Issue 21, Pages 11131-11137Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b01798
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Funding
- Science and Engineering Research Board (SERB-DST), Government of India [SR/S1/OC/12/2012]
- DST
- UGC
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A transition-metal-free, three-component coupling involving N-substituted aziridines, arynes, and water promoted by trifluoroacetic acid (TFA) has been reported. The reaction furnished medicinally important N-aryl beta-amino alcohol derivatives in moderate to good yields. In addition, the use of azetidines in this reaction afforded N-aryl gamma-amino alcohol derivatives.
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