Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 80, Issue 4, Pages 2384-2391Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b00037
Keywords
-
Categories
Funding
- MEXT
- JSPS, Japan
- Grants-in-Aid for Scientific Research [25620084] Funding Source: KAKEN
Ask authors/readers for more resources
A copper-mediated formally dehydrative biaryl coupling of azine N-oxides and oxazoles has been developed. The CC bond-forming process proceeds, accompanied by the removal of the oxygen atom from the azine core, to directly afford the azineoxazole biaryl linkage. Moreover, this system requires no noble transition metals such as palladium and rhodium, which are common promotors in the related dehydrogenative couplings with the azine N-oxide. Thus, the present protocol can provide a unique and less expensive approach to the azine-containing biheteroaryls of substantial interest in pharmaceutical and medicinal chemistry.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available