Advances in Inhalation Dosimetry Models and Methods for Occupational Risk Assessment and Exposure Limit Derivation

Evaluation of possible modes of action for acute effects of methyl iodide in laboratory animals

(2016) Christopher R. Kirman et al.   INHALATION TOXICOLOGY

Iodomethane human health risk characterization

(2016) Beth E. Mileson et al.   INHALATION TOXICOLOGY

Development of a physiologically based pharmacokinetic (PBPK) model for methyl iodide in rats, rabbits, and humans

(2016) Lisa M. Sweeney et al.   INHALATION TOXICOLOGY

Computational modeling of nanoscale and microscale particle deposition, retention and dosimetry in the mouse respiratory tract

(2014) B. Asgharian et al.   INHALATION TOXICOLOGY

Proper knowledge on toxicokinetics improves human hazard testing and subsequent health risk characterisation. A case study approach

(2013) Jos G.M. Bessems et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Application of Markov chain Monte Carlo analysis to biomathematical modeling of respirable dust in US and UK coal miners

(2013) Lisa M. Sweeney et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Development of a rhesus monkey lung geometry model and application to particle deposition in comparison to humans

(2012) Bahman Asgharian et al.   INHALATION TOXICOLOGY

Efficient internalization and intracellular translocation of inhaled gold nanoparticles in rat alveolar macrophages

(2012) Shinji Takenaka et al.   Nanomedicine

Biologically-based modeling insights in inhaled vapor absorption and dosimetry

(2012) John B. Morris   PHARMACOLOGY & THERAPEUTICS

Comparative Computational Modeling of Airflows and Vapor Dosimetry in the Respiratory Tracts of Rat, Monkey, and Human

(2012) R. A. Corley et al.   TOXICOLOGICAL SCIENCES

Assessing the relevance of in vitro studies in nanotoxicology by examining correlations between in vitro and in vivo data

(2012) Xianglu Han et al.   TOXICOLOGY

Using population physiologically based pharmacokinetic modeling to determine optimal sampling times and to interpret biological exposure markers: The example of occupational exposure to styrene

(2012) Marc-André Verner et al.   TOXICOLOGY LETTERS

Derivation of Mass Transfer Coefficients for Transient Uptake and Tissue Disposition of Soluble and Reactive Vapors in Lung Airways

(2011) B. Asgharian et al.   ANNALS OF BIOMEDICAL ENGINEERING

A computer model for the simulation of fiber–cell interaction in the alveolar region of the respiratory tract

(2011) R. Sturm   COMPUTERS IN BIOLOGY AND MEDICINE

Informing Selection of Nanomaterial Concentrations for ToxCast in Vitro Testing Based on Occupational Exposure Potential

(2011) Sumit Gangwal et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Nanotoxicology: in Vitro–in Vivo Dosimetry

(2011) Günter Oberdörster   ENVIRONMENTAL HEALTH PERSPECTIVES

Binding of polystyrene and carbon black nanoparticles to blood serum proteins

(2011) Stefanie Fertsch-Gapp et al.   INHALATION TOXICOLOGY

Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes

(2011) Robert R Mercer et al.   Particle and Fibre Toxicology

Assessment of margin of exposure based on biomarkers in blood: An exploratory analysis

(2011) Lesa L. Aylward et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

QSARs for PBPK modelling of environmental contaminants

(2011) T. Peyret et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Physiologically Based Pharmacokinetic Model Use in Risk Assessment—Why Being Published Is Not Enough

(2011) Eva D. McLanahan et al.   TOXICOLOGICAL SCIENCES

A Validated Hybrid Computational Fluid Dynamics-Physiologically Based Pharmacokinetic Model for Respiratory Tract Vapor Absorption in the Human and Rat and Its Application to Inhalation Dosimetry of Diacetyl

(2011) Eric Gloede et al.   TOXICOLOGICAL SCIENCES

A computational fluid dynamics approach to assess interhuman variability in hydrogen sulfide nasal dosimetry

(2010) Jeffry D. Schroeter et al.   INHALATION TOXICOLOGY

Modelling particle retention in the alveolar–interstitial region of the human lungs

(2010) D Gregoratto et al.   JOURNAL OF RADIOLOGICAL PROTECTION

Concept of Assessing Nanoparticle Hazards Considering Nanoparticle Dosemetric and Chemical/Biological Response Metrics

(2010) Erik K. Rushton et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies

(2010) Paul M Hinderliter et al.   Particle and Fibre Toxicology

Particle clearance in the alveolar-interstitial region of the human lungs: model validation

(2010) D. Gregoratto et al.   RADIATION PROTECTION DOSIMETRY

The Use of In Vitro Toxicity Data and Physiologically Based Kinetic Modeling to Predict Dose-Response Curves for In Vivo Developmental Toxicity of Glycol Ethers in Rat and Man

(2010) Jochem Louisse et al.   TOXICOLOGICAL SCIENCES

Poorly soluble particulates: Searching for a unifying denominator of nanoparticles and fine particles for DNEL estimation

(2010) Jürgen Pauluhn   TOXICOLOGY

Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling for in vivo inhalation gas uptake data exposure in female B6C3F1 mice

(2010) M.V. Evans et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Induction of aneuploidy by single-walled carbon nanotubes

(2009) L.M. Sargent et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Deposition of inhaled nanoparticles in the rat nasal passages: Dose to the olfactory region

(2009) Guilherme J. M. Garcia et al.   INHALATION TOXICOLOGY

Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs

(2009) Wolfgang G. Kreyling et al.   INHALATION TOXICOLOGY

Physiologically Based Pharmacokinetic Modeling of Cyclohexane as a Tool for Integrating Animal and Human Test Data

(2009) A. M. Hissink et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

A theoretical approach to the deposition and clearance of fibers with variable size in the human respiratory tract

(2009) Robert Sturm et al.   JOURNAL OF HAZARDOUS MATERIALS

Comparison of micron- and nanoparticle deposition patterns in a realistic human nasal cavity

(2009) S.M. Wang et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Quantitative Risk Analysis for N-Methyl Pyrrolidone Using Physiologically Based Pharmacokinetic and Benchmark Dose Modeling

(2009) Torka S. Poet et al.   TOXICOLOGICAL SCIENCES

Upper Respiratory Tract Uptake of Naphthalene

(2009) John B. Morris et al.   TOXICOLOGICAL SCIENCES

Investigations of the Use of Bioavailability Data to Adjust Occupational Exposure Limits for Active Pharmaceutical Ingredients

(2009) Bruce D. Naumann et al.   TOXICOLOGICAL SCIENCES

Identification of Intestinal Loss of a Drug through Physiologically Based Pharmacokinetic??Simulation of Plasma??Concentration-Time Profiles

(2008) Sheila Annie Peters   CLINICAL PHARMACOKINETICS

Application of Physiological Computational Fluid Dynamics Models to Predict Interspecies Nasal Dosimetry of Inhaled Acrolein

(2008) Jeffry D. Schroeter et al.   INHALATION TOXICOLOGY

Nasal Uptake of Inhaled Acrolein in Rats

(2008) Melanie F. Struve et al.   INHALATION TOXICOLOGY

Concordance BetweenInVitroandInVivoDosimetry in the Proinflammatory Effects of Low-Toxicity, Low-Solubility Particles: The Key Role of the Proximal Alveolar Region

(2008) K. Donaldson et al.   INHALATION TOXICOLOGY

Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: The first steps

(2008) George Loizou et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Inhalation Dosimetry of Diacetyl and Butyric Acid, Two Components of Butter Flavoring Vapors

(2008) John B. Morris et al.   TOXICOLOGICAL SCIENCES

Development and specification of physiologically based pharmacokinetic models for use in risk assessment

(2007) Rebecca A. Clewell et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY