Article
Immunology
Shin Ju Oh, Young Nam Kwon, Chang Kyun Lee, Jin San Lee
Summary: This is the first report of infliximab-associated anti-NMDAR encephalitis in Crohn's disease, highlighting the need for clinicians to recognize the possibility of a paradoxical autoimmune response occurring with novel biological therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Geosciences, Multidisciplinary
Qiang Sun, Jun Meng, Yu Lan, Guohong Shi, Xu Yang, Dianyun Cao, Wenfu Chen, Xiaori Han
Summary: The study found that an appropriate dosage of biochar can increase soil aggregate stability and organic carbon content, improving soil structure. However, exceeding a certain dosage may lead to a decrease in mean weight diameter of soil aggregates.
Article
Dermatology
Anna Lis-Swiety, Aleksandra Fratczak
Summary: Mild to moderate psoriasis is commonly treated with topical therapy. This article reviews literature on topical treatments that have been evaluated in clinical trials and real-life studies lasting at least 12 months. The use of calcipotriol/bethamethasone dipropionate foam as maintenance treatment can improve the efficacy and safety of topical therapy in psoriatic patients. Introducing new nonsteroidal topical drugs and adopting proactive therapy appear to be crucial for achieving satisfactory long-term outcomes in psoriasis.
DERMATOLOGIC THERAPY
(2022)
Article
Biology
Mateusz Kamil Ozog, Beniamin Oskar Grabarek, Magdalena Wierzbik-Stronska, Magdalena Swider
Summary: This article discusses the relationship between psoriasis and the nervous system and analyzes the mechanisms that lead to neurological complications during anticytokine therapies. Biological drugs used in psoriasis have positive therapeutic results but also come with side effects. Serious neurological side effects are most often seen with the use of anti-TNF-alpha drugs, requiring monitoring and early intervention.
Review
Immunology
Xiao-ce Cai, Yi Ru, Liu Liu, Xiao-ying Sun, Ya-qiong Zhou, Ying Luo, Jia-le Chen, Miao Zhang, Chun-xiao Wang, Xin Li, Bin Li
Summary: This study evaluated the effectiveness and safety of biological agents for treating children with psoriasis through high-quality randomized controlled trials. The results showed that biologics are effective and safe for pediatric patients with psoriasis, with ustekinumab showing the best efficacy and the fewest adverse effects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Laetitia S. Gaspar, Janina Hesse, Muge Yalcin, Barbara Santos, Catarina Carvalhas-Almeida, Mafalda Ferreira, Joaquim Moita, Angela Relogio, Claudia Cavadas, Ana Rita Alvaro
Summary: The study revealed that obstructive sleep apnea (OSA) affects the biological clock, and long-term continuous positive airway pressure (CPAP) treatment can partially restore normal clock function. However, the treatment does not fully reverse the impact on clock gene expression levels.
Review
Gastroenterology & Hepatology
Teresa Broquetas, Jose A. Carrion
Summary: The estimated global prevalence of HBV infection is about 316 million. Despite universal vaccination programs and effective antiviral therapy, HBV infection remains a major cause of cirrhosis and hepatocellular carcinoma. Nucleos(t)ide analogues (NA) have been the preferred treatment for chronic hepatitis B for many years, but the low probability of HBV surface antigen seroclearance requires indefinite treatment. Recent advances in understanding the viral cycle and the role of the immune system have led to the development of new therapeutic approaches and ongoing clinical trials with promising results.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Sunil Dogra, Hitaishi Mehta
Summary: Erythrodermic psoriasis is a severe and potentially life-threatening form of psoriasis, which is less responsive to conventional therapies. The advent of newer biologics, particularly IL-17 and IL-23 inhibitors, has shown promise in the management of EP. However, there is a lack of high-quality evidence regarding their long-term efficacy and safety, and the management of patients with prior biologic failure remains challenging.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2022)
Article
Medicine, General & Internal
Funda Tamer, Yusuf Can Edek, Ahmet Burhan Aksakal
Summary: This study evaluated the effect of biologic agent treatment on serum uric acid levels in patients with psoriasis. The results showed a significant decrease in serum uric acid levels in patients after 3 months of biologic agent treatment. Treatment with specific biologic agents such as adalimumab, infliximab, ixekizumab, secukinumab, and ustekinumab resulted in a significant decrease in uric acid levels.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Immunology
Meital Oren-Shabtai, Daniel Mimouni, Adi Nosrati, Lihi Atzmony, Baruch Kaplan, Aviv Barzilai, Sharon Baum
Summary: This study describes the clinical and immunological features of patients with recalcitrant BP treated with immunobiological therapies. The results show that the use of biological treatment can significantly improve the condition of BP patients and has no adverse events.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
M. Lebwohl, D. Thaci, R. B. Warren
Summary: Long-term proactive management is superior to reactive management in prolonging time to first relapse, reducing number of relapses, and increasing days in remission in adults with psoriasis vulgaris. Cal/BD foam is well tolerated and should be considered for long-term proactive management of psoriasis patients.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Medicine, General & Internal
Yukari Okubo, Ann Chuo Tang, Sachie Inoue, Hitoe Torisu-Itakura, Mamitaro Ohtsuki
Summary: The study found that patients and physicians using biologics have higher treatment goals compared to non-biologics users, and biologic users also reported higher treatment satisfaction. Setting appropriate treatment goals that are shared between patients and their physicians may lead to better treatment outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dermatology
Asa Krantz, Juan Jesus Carrero, Yuanhang Yang, Lovisa Schalin, Josefin Lysell, Faizan Mazhar
Summary: Limited information exists regarding the treatment of patients with psoriasis/psoriatic arthritis in primary care. This study assessed treatment patterns, adherence, persistence, and compliance in newly diagnosed patients from 2012 to 2018 in Stockholm, Sweden. The findings revealed gaps in pharmacological care, including suboptimal adherence/persistence and inadequate laboratory monitoring.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Urology & Nephrology
Lillian Xie, Shlomi Tapiero, Alec R. Flores, Manuel Armas-Phan, Luke Limfueco, Rajiv Karani, Pengbo Jiang, Kaitlan D. Cobb, Roger L. Sur, Thomas Chi, Jaime Landman, Kamaljot S. Kaler, Ralph Clayman
Summary: Long-term preoperative antibiotics can reduce postoperative complications in patients with xanthogranulomatous pyelonephritis undergoing laparoscopic nephrectomy and shorten the length of stay.
JOURNAL OF UROLOGY
(2021)
Article
Gastroenterology & Hepatology
Wan-Ting Cao, Rong Huang, Shan Liu, Yi-Hong Fan, Mao-Sheng Xu, Yi Xu, Hui Ni
Summary: This study aimed to explore the predictive value of infliximab trough level (ITL) in combination with inflammatory biomarkers on long-term endoscopic outcomes in Crohn's disease (CD) patients during infliximab (IFX) maintenance therapy. The results showed that low ITL and high inflammatory biomarker levels increased the risk of endoscopic activity at different stages of treatment. The combination of ITL and inflammatory biomarkers can moderately predict endoscopic activity. Furthermore, ITL was also associated with endoscopic relapse-free survival.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Dermatology
Lydia Ouchene, Anastasiya Muntyanu, Deborah Assayag, Evicka Veilleux, Andy Abril, Giovanni Ferrara, Elaine Yacyshyn, Christian A. Pineau, Elizabeth O'Brien, Murray Baron, Mohammed Osman, Robert Gniadecki, Elena Netchiporouk
Summary: This article introduces dermatologists to the noninfectious inflammatory skin diseases associated with pulmonary involvement and emphasizes the importance of screening and monitoring for lung disease in high-risk patients. It also highlights the need for dermatologists to recognize cutaneous manifestations of lung disease and refer patients to pulmonary specialists for appropriate treatment. The article emphasizes the common pulmonary complications and high mortality rates associated with autoimmune connective tissue diseases, sarcoidosis, vasculitis, and autoimmune blistering diseases.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Editorial Material
Dermatology
Melika Motamedi, Giovanni Ferrara, Elaine Yacyshyn, Mohammed Osman, Andy Abril, Samia Rahman, Elena Netchiporouk, Robert Gniadecki
Summary: Numerous inflammatory, neoplastic, and genetic skin disorders are associated with interstitial lung disease (ILD), the fibrosing inflammation of lung parenchyma that has significant morbidity and mortality. Therefore, the dermatologist plays a major role in the early detection and appropriate referral of patients at risk for ILD.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Editorial Material
Dermatology
Valeska Padovese, Lucinda C. Fuller, Christopher E. M. Griffiths, Toby Maurer, Esther Freeman
Summary: Skin diseases are prevalent in refugee camps due to a lack of skilled professionals, limited access to diagnostics and medications. This perspective highlights the importance of dermatologists in providing adequate care for migrants and displaced persons during humanitarian crises.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yiqiao Chen, Christopher E. M. Griffiths, Silvia Bulfone-Paus
Summary: The skin is equipped with immune cells like mast cells and CD8 T cells which play a role in recognizing and responding to environmental challenges. These cells are essential for maintaining tissue balance and regulating the immune response in skin diseases. Studies have shown that mast cells can influence the migration and function of CD8 T cells, while CD8 T cells can also activate mast cells. The close proximity between mast cells and CD8 T cells has been observed in dermatoses such as alopecia areata. This review summarizes the bidirectional interactions between human mast cells and CD8 T cells, focusing on their involvement in psoriasis, atopic dermatitis, and vitiligo, and discusses unresolved questions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dermatology
Jorg C. Prinz, Siew Eng Choon, Christopher E. M. Griffiths, Joseph F. Merola, Akimichi Morita, Darren M. Ashcroft, Manuelle Viguier
Summary: Generalized pustular psoriasis (GPP) is a rare auto-inflammatory skin disease with acute episodes of pustule formation. Understanding the epidemiology and clinical data of GPP is challenging due to its rarity. This review article provides an overview of GPP prevalence estimates in key demographics, genetic mutations associated with the disease, incidence of comorbidities, mortality rate, and causes of death.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Marleine Azar, Francois Lagace, Anastasiya Muntyanu, Elena Netchiporouk, Youwen Zhou, Charles Lynde, Linda Moreau, Steve Mathieu, Denis Sasseville, Rachel Asiniwasis, Neil H. Shear, Robert Gniadecki, Elham Rahme, Ivan V. Litvinov
Summary: This study examined the relationship between h-index and academic rank, sex, and other factors in dermatology in Canada. The results showed an increase in female dermatologists and found no association between h-index and sex.
Review
Dermatology
Leena Chularojanamontri, Krittaya Rattanakorn, Narachai Julanon, Mati Chuamanochan, Christopher E. M. Griffiths
Summary: This article reviews the similarities and differences between acrodermatitis continua of Hallopeau (ACH) and generalized pustular psoriasis (GPP). IL-36RN mutations are more commonly found in GPP patients, while ACH patients have a lower frequency of these mutations. Although ACH can occur before, simultaneously, or after the development of GPP, the response to treatment appears to differ between the two conditions. Based on the findings, ACH should be classified separately from GPP rather than being considered a subtype of GPP.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
Aaron M. M. Drucker, Omer Kleiner, Rachael Manion, Anie Philip, Jan Dutz, Kathleen Barnard, Julie Fradette, Lucie Germain, Robert Gniadecki, Ivan Litvinov, Sarvesh Logsetty, Morris Manolson, P. Regine Mydlarski, Vincent Piguet, Debbie Ward, Youwen Zhou, An-Wen Chan
Summary: The Skin Investigation Network of Canada (SkIN Canada) identified the top ten research priorities for nine key skin conditions through surveys, scoping reviews, and workshops, emphasizing the importance of involving patients and healthcare providers.
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2023)
Article
Cell Biology
Robert Gniadecki, Sandra O'Keefe, Dylan Hennessey, Aishwarya Iyer
Summary: Ultraviolet radiation is a strong carcinogen responsible for most skin cancers. However, its role in the pathogenesis of mycosis fungoides (MF) is still controversial.
Article
Dermatology
Kim A. Papp, Barbara Melosky, Sandeep Sehdev, Sebastien J. Hotte, Jennifer R. Beecker, Mark G. Kirchhof, Irina Turchin, Jan P. Dutz, Melinda J. Gooderham, Robert Gniadecki, Chih-ho Hong, Jo Lambert, Charles W. Lynde, Vimal H. Prajapati, Ronald B. Vender
Summary: Patients with previously treated solid tumors may have an increased risk of cancer recurrence when treated with systemic therapies for psoriasis, but for patients with a good cancer prognosis, treating psoriasis with systemic therapies may offer quality-of-life benefits.
DERMATOLOGY AND THERAPY
(2023)
Letter
Dermatology
A. Armstrong, K. Eyerich, C. Conrad, Y. Zhu, Y. -w. Yang, M. Miller, Y. You, Y. -k. Shen, P. Foley, C. E. M. Griffiths, B. Strober
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Teng-Chou Chen, Ting-Chun Wang, Zenas Z. N. Yiu, Meng-Sui Lee, Li-Chia Chen, K. Arnold Chan, Christopher E. M. Griffiths, Darren M. Ashcroft, Global Psoriasis Atlas GPA
Summary: This study examined the risks of serious infections and infection mortality in patients with psoriasis. The results showed that patients with psoriasis had a higher risk of serious infection and infection-related mortality, especially those with moderate-to-severe psoriasis.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Dermatology
Rachel Sommer, Ulrich Mrowietz, Kristian Gaarn Du Jardin, Ismail Kasujee, Elisa Martini, Esteban Dauden, Gabriella Fabbrocini, Alexander Zink, Christopher E. M. Griffiths, Matthias Augustin
Summary: Psoriasis has negative impacts on physical, mental, and social health, leading to reduced quality of life. Current management of psoriasis may not adequately address all aspects of health. In order to restore or maintain health, healthcare should focus on the patient's overall well-being, including life satisfaction, quality of life, and mental well-being. This expert review emphasizes the importance of incorporating well-being into the holistic therapeutic approach for psoriasis patients, and provides recommendations for clinical practice to implement well-being assessment and treatment.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Oncology
Francois Lagace, Bibi Nuzha Noorah, Santina Conte, Lorena Alexandra Mija, Jasmine Chang, Leila Cattelan, Jonathan LeBeau, Joel Claveau, Irina Turchin, Wayne Gulliver, Robert Gniadecki, Elena Netchiporouk, Wilson H. Miller, Thomas G. Salopek, Elham Rahme, Sandra Pelaez, Ivan V. Litvinov
Summary: This study compared the differences in sun exposure, sun protection, and level of worry for cutaneous melanoma between high-incidence and low-incidence provinces in Atlantic Canada, as well as between different demographic groups. The findings identified significant differences across multiple variables, which will help guide future public health efforts in preventing and reducing the incidence of cutaneous melanoma in the communities.
Correction
Dermatology
Kim A. Papp, Jennifer Beecker, Curtis Cooper, Mark G. Kirchhof, Anton L. Pozniak, Juergen K. Rockstroh, Jan P. Dutz, Melinda J. Gooderham, Robert Gniadecki, Chih-ho Hong, Charles W. Lynde, Catherine Maari, Yves Poulin, Ronald B. Vender, Sharon L. Walmsley
DERMATOLOGY AND THERAPY
(2023)
