Article
Dermatology
Woraphong Manuskiatti, Arisa Kaewkes, Chadakan Yan, Janice Natasha Ng, Joshua Zev Glahn, Rungsima Wanitphakdeedecha
Summary: The study demonstrated that fractional laser monotherapy is effective for hypertrophic scars, and the application of topical corticosteroid does not provide a long-term synergistic effect to fractional laser monotherapy.
ACTA DERMATO-VENEREOLOGICA
(2021)
Article
Pharmacology & Pharmacy
Qing Guo, Mingjie He, Junjie Cen, Danqi Huang, Shaoyun Hao, Zengqi Tang, Hui Xiong
Summary: The study found that ablative fractional laser therapy and assisted delivery of methotrexate are effective and safe treatments for localized scleroderma (LS).
Article
Dermatology
Woraphong Manuskiatti, Chadakan Yan, Ofir Artzi, Mia Katrina R. Gervasio, Rungsima Wanitphakdeedecha
Summary: The study compared the efficacy and safety of thermomechanical fractional injury (TMFI)-assisted topical corticosteroid delivery with corticosteroid injection in the treatment of hypertrophic scar (HTS). Results showed that TMFI-assisted topical corticosteroid delivery is an effective treatment for HTS with a lower risk of adverse effects compared to corticosteroid injection.
LASERS IN SURGERY AND MEDICINE
(2022)
Article
Dermatology
Faten Abd ElWadoud Abd ElKawy, Shaimaa Hassan Mohammed Aly, Shady Mahmoud Attia Ibrahim
Summary: Fractional CO2 laser and microneedling are effective treatment modalities for alopecia areata, providing transepidermal drug delivery. Dermoscopy is a valuable tool for identifying disease activity and early signs of clinical improvement during treatment.
DERMATOLOGIC THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Natallia V. Dubashynskaya, Yury A. Skorik
Summary: This review discusses the approaches and techniques for improving the biopharmaceutical properties of topical corticosteroids using mucoadhesive polymer patches. It focuses on increasing bioadhesion, modifying drug release, and improving local bioavailability and safety.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Instruments & Instrumentation
Juhyun Park, Yeu-Chun Kim
Summary: Keloids are skin conditions induced by injuries, and a study has suggested a promising treatment method using microneedles to deliver 5-fluorouracil (5-FU) loaded carboxymethyl chitosan (CMC) nanoparticles directly into keloid fibroblasts. This delivery system not only inhibits the fibroblasts effectively but also has the feasibility of self-administration without pain, showing potential for treating keloid scars.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Haoran Guo, Xiangyu Zhang, Hui Li, Chuhan Fu, Ling Jiang, Yibo Hu, Jinhua Huang, Jing Chen, Qinghai Zeng
Summary: Fractional CO2 laser is commonly used in the treatment of various skin diseases. This study investigated the changes in skin function and regulatory mechanisms after fractional CO2 laser treatment. The results showed that the laser transformed the lesions into normal skin, regulated the skin barrier, rearranged collagen, enhanced local microvascular circulation, activated the immune system, and aided drug transport.
Review
Chemistry, Multidisciplinary
Lingbo Shen, Guihua Fang, Bo Tang, Qiang Zhu
Summary: Topical corticosteroids are the primary treatment for ocular inflammation, and factors such as drug properties and administration strategies affect drug bioavailability in the eye. Currently, there is a lack of rational and dynamic approaches to strategy selection.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Dermatology
Cen-Hung Lin, Yueh-Ju Tsai, Shun-Yu Chi, Mu-Han Hsieh, Ko-Chien Lin, Hui-Ping Lin, Shiun-Yuan Hsu, Hui-Hong Tsai, Ching-Hua Hsieh
Summary: This study demonstrated that topical delivery of steroids after fractional ablative carbon dioxide laser treatment is effective in treating postthyroidectomy hypertrophic scarring, with significant improvements in symptoms and appearance of the scars.
DERMATOLOGICA SINICA
(2022)
Review
Pharmacology & Pharmacy
Yiwen Zhao, Jewel Voyer, Yibo Li, Xinliang Kang, Xinyuan Chen
Summary: This review discusses the application of ablative fractional laser (AFL) in facilitating topical drug delivery, including transdermal, transungual, and transocular drug delivery. AFL has been found to be safe and effective in enhancing drug delivery, reducing treatment time, and improving treatment outcomes.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hamid Reza Khalighi, Massoud Mojahedi, Azadeh Parandoosh
Summary: The study evaluated the efficacy of using Er,Cr:YSGG laser irradiation before the application of topical anesthesia on oral mucosa. The results showed a significant increase in anesthesia depth in the test group compared to the control group at different time points.
CLINICAL ORAL INVESTIGATIONS
(2021)
Review
Engineering, Biomedical
Kelvin Truong, Ines Prasidha, Tevi Wain
Summary: This study aimed to investigate the clinical efficacy and adverse events of laser-assisted drug delivery in treating hypertrophic and keloid scars. Results indicated a need for more high-quality randomized controlled trials to assess the effectiveness of laser-assisted drug delivery in scar treatment.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Dermatology
Yasser A. Helmy, Mohamed Hashem El Batreek, Doaa Ahmed Abdel Fadeel, Abeer Attia Tawfik, Nevien Ahmed Samy
Summary: This study found that laser-assisted delivery of topical cyclosporine can provide comparable clinical and pathological improvement to that of clobetasol in the treatment of mild to moderate plaque psoriasis. However, topical steroid showed more significant improvement, particularly in patients with less widespread disease.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Emergency Medicine
Yan Yang, Lutong Liu, Xiaojin Wu, Xue Wang, Qiang Lu, Zhen Zhang
Summary: This study investigated the permeability of silk nanofiber hydrogels loaded with hydrophilic and hydrophobic model molecules into hypertrophic scar tissues mediated by CO2 fractional laser irradiation. The results showed that SNFs promoted the penetration of hydrophilic drug R6G but not the hydrophobic drug R110. Combining laser irradiation with SNF drug delivery improved the efficiency of hydrophilic drug delivery.
Article
Dermatology
Niti Tawaranurak, Pitchaya Pliensiri, Krongthong Tawaranurak
Summary: The combination of fractional CO2 laser with topical triamcinolone (TA) has a similar therapeutic effect on keloids compared to intralesional TA. However, the combination treatment can better reduce scar volume and significantly decrease Vancouver Scar Scale (VSS) scores. It is an alternative and effective option for the treatment of keloids.
INTERNATIONAL WOUND JOURNAL
(2022)
Letter
Dermatology
Clemence Bertold, Philippe Martel, Thierry Passeron, Philippe Bahadoran
Summary: The presence of pigmented circles around hair follicles is a key feature in diagnosing lentigo maligna and benign pigmented macules. In this case report, reflectance confocal microscopy was used to diagnose pigmented demodicosis instead of lentigo maligna, avoiding an unnecessary biopsy and shedding light on the mechanisms of hyperpigmentation.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
David Alvarez Martinez, Clemence Bertold, Florence Le Duff, Philippe Bahadoran, Thierry Passeron
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Editorial Material
Dermatology
Wei Liu, Jean Krutmann, Yan Tian, Corinne Granger, Jaime Piquero-Casals, Carles Trullas, Thierry Passeron, Henry W. Lim, Wei Lai
Summary: The medical literature on aesthetic dermatology has largely overlooked the needs of patients with darker skin types, who have different concerns and priorities. In Chinese individuals, pigment alteration is a major concern as it is associated with aging and a cultural beauty standard of fair skin. Non-invasive cosmetic procedures like lasers and injections are also popular in China, but can lead to hyperpigmentation as a side effect in this population. It is important to consider and tailor approaches to address both primary concerns of photoaging and the side effects of cosmetic treatments.
DERMATOLOGY AND THERAPY
(2023)
Article
Dermatology
Hanene Bzioueche, Katia Boniface, Claire Drullion, Sandrine Marchetti, Berengere Chignon-Sicard, Laura Sormani, Stephane Rocchi, Julien Seneschal, Thierry Passeron, Meri K. Tulic
Summary: Vitiligo is an autoimmune disease characterized by melanocyte loss and white patches on the skin. This study demonstrates that house dust mite (HDM) can induce inflammatory responses and melanocyte detachment in vitiligo through protease activity. HDM may act as an external source of pathogen-associated molecular pattern molecules in vitiligo, and MMP-9 inhibitors could be potential therapeutic targets. Furthermore, studying specific vitiligo endophenotypes can help understand the environmental contribution to the disease.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Editorial Material
Dermatology
Thierry Passeron
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Letter
Dermatology
David Alvarez Martinez, Elodie Long-Mira, Thierry Passeron, Philippe Bahadoran
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Adrien Sanchez, Elisa Demonchy, Mathieu Buscot, Nathalie Cardot-Leccia, Kamel Lagha, Henri Montaudie, Thierry Passeron
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Julie Bulsei, Eric Fontas, Thierry Passeron
Summary: This study assessed the socioeconomic status (SES) of HS patients using the French DEPrivation index (FDep) and found a significant association between HS and low SES in the adult population. In children aged 7-17, low SES was associated with obesity and tobacco consumption, but no association with HS was observed after matching for these confounding factors.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
F. Flament, D. G. Mercurio, E. Catalan, E. Bouhadanna, C. Delaunay, D. F. Miranda, T. Passeron
Summary: This study aimed to evaluate the effectiveness of a photoprotective product in counteracting the aging process of different skin types. The results showed that daily application of a high photoprotective product significantly slowed down skin aging.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Corinne Granger, Thierry Passeron, Carles Trullas, Muzzammil Hosenally, Bibi Nusayha Sokeechand, Jean Krutmann, Henry W. Lim
Summary: This study compared the differences in erythema and pigmentation responses of Chinese and White European individuals to three different sunscreens in outdoor conditions. The findings showed that White Europeans had a higher incidence of erythema response and a higher rate of photoprotection failure, especially with SPF 15 and 30 sunscreens. Therefore, ethnicity should be taken into account when making recommendations for sun safety.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2023)
Letter
Dermatology
Julie Bulsei, Eric Fontas, Thomas Hubiche, Thierry Passeron
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Clemence Bertold, Eric Fontas, Tanya Singh, Nadia Gastaut, Sandra Ruitort, Sylvia Wehrlen Pugliese, Thierry Passeron
Summary: This study aimed to assess the efficacy and tolerance of a New Trio (NT) combination compared to Kligman's trio (KT) in treating melasma. The results showed that both the NT and KT groups demonstrated significant improvement in mMASI after 12 weeks, with the NT group showing a more significant improvement. Therefore, the NT combination can be considered as an effective treatment option for melasma with better tolerance.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
T. Passeron, H. W. Lim, C. L. Goh, H. Y. Kang, C. Ribeyre, A. -l. Demessant-Flavigny, C. Le Floc'h, D. Kerob, J. Krutmann, C. Comte, B. Dreno, M. T. Leccia
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Julien Seneschal, Reinhart Speeckaert, Alain Taieb, Albert Wolkerstorfer, Thierry Passeron, Amit G. Pandya, Henry W. Lim, Khaled Ezzedine, Youwen Zhou, Flora Xiang, Steven Thng, Atsushi Tanemura, Tamio Suzuki, David Rosmarin, Michelle Rodrigues, Noufal Raboobee, Georg Pliszewski, Davinder Parsad, Naoki Oiso, Paul Monteiro, Jean Marie Meurant, Nicolle Maquignon, Harvey Lui, Caroline Le Poole, Giovanni Leone, Ai-Young Lee, Eric Lan, Ichiro Katayama, Richard Huggins, Sang Ho Oh, John E. Harris, Iltefat H. Hamzavi, Somesh Gupta, Pearl Grimes, Boon Kee Goh, Deepti Ghia, Samia Esmat, Viktoria Eleftheriadou, Markus Boehm, Laila Benzekri, Marcel Bekkenk, Jung Min Bae, Augustin Alomar, Marwa Abdallah, Mauro Picardo, Nanja Van Geel
Summary: This study presents internationally agreed-upon expert-based recommendations for the treatment of vitiligo, including the use of topical and systemic therapies, phototherapies, intervention strategies, and the status of innovative therapies. The development of new treatments for vitiligo is ongoing.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Nanja van Geel, Reinhart Speeckaert, Alain Taieb, Khaled Ezzedine, Henry W. Lim, Amit G. Pandya, Thierry Passeron, Albert Wolkerstorfer, Marwa Abdallah, Augustin Alomar, Jung Min Bae, Marcel Bekkenk, Laila Benzekri, Markus Boehm, Viktoria Eleftheriadou, Samia Esmat, Deepti Ghia, Boon Kee Goh, Pearl Grimes, Somesh Gupta, Iltefat H. Hamzavi, John E. Harris, Sang Ho Oh, Richard Huggins, Ichiro Katayama, Eric Lan, Ai-Young Lee, Giovanni Leone, Caroline Le Poole, Harvey Lui, Nicolle Maquignon, Jean Marie Meurant, Paul Monteiro, Naoki Oiso, Davinder Parsad, Georg Pliszewski, Noufal Raboobee, Michelle Rodrigues, David Rosmarin, Tamio Suzuki, Atsushi Tanemura, Steven Thng, Flora Xiang, Youwen Zhou, Mauro Picardo, Julien Seneschal
Summary: This article presents a management algorithm for the diagnosis, assessment, and treatment of vitiligo. The algorithms emphasize the importance of shared decision-making and provide detailed discussions on treatment goals. The article highlights the significance of evaluating disease activity in tailoring treatment approaches.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
