Article
Surgery
Nabil Fakih-Gomez, Jonathan Kadouch
Summary: The study demonstrates that the combination of CaHA and CPM-HA is effective in volumizing and lifting the cheeks and jawline, with no reported adverse events.
AESTHETIC PLASTIC SURGERY
(2022)
Review
Dermatology
Kathryn Rentfro, Dillon Clarey, Emily J. Glenn, Ronald Sulewski, Ashley Wysong
Summary: This study systematically compiles cases of necrosis caused by soft tissue fillers and collects data on injection, treatment, and outcomes. The majority of necrosis cases analyzed were a result of hyaluronic acid injections in the nasolabial fold. Hyaluronidase was the most commonly used initial treatment agent for necrosis. This review serves as a valuable reference for clinicians and providers encountering necrosis from soft tissue fillers.
DERMATOLOGIC SURGERY
(2022)
Article
Dermatology
Irem Yanatma, Gulbahar Sarac, Mehmet Gul, Semir Gul, Yelda Kapicioglu
Summary: The study compared the effects of PCL and CaHA fillers on rat skin, finding that both are effective in increasing dermal collagen density and amount, preventing dermis atrophy, and showed no advantage over each other in this respect. PCL filler provides more fibroblast increase compared to CaHA filler, but the effect of stimulating fibroblast proliferation takes longer.
DERMATOLOGIC THERAPY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Sansur S. Al-Alam, D. Destang
Summary: Impending skin necrosis caused by inadvertent intravascular injection of hyaluronic acid fillers can have serious consequences. This systematic review evaluates the effectiveness of a high-dose pulsed hyaluronidase management protocol in preventing skin necrosis. The review finds that immediate intervention using this protocol can halt the progression of necrosis and prevent permanent sequelae. However, the conclusions are limited by the lack of high-quality evidence.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2023)
Article
Dermatology
Alan Durkin, Alexandra Lackey, Alyssa Tranchilla, Maxwell Poling, Gabriella Glassman, Nick Woltjen
Summary: This study compared aesthetic improvement achieved with 3 cc of either calcium hydroxyapatite with integral lidocaine CaHA(+) or VYC-20L in the midface. CaHA(+) showed better and more durable outcomes than VYC-20L, providing higher value to the patient.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Dermatology
Motaz Dairi, Sami Sawan, Alaa Aref, Noof Helmi, Hind Abdulmajed, Eman Aldigs
Summary: The study found no evidence of contamination associated with the reuse of HA gel fillers, regardless of concentration and injection site. Implementing proper sterilization procedures can extend the usability of HA gel fillers, and there was no correlation between storage time and the risk of contamination.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Salvatore Piero Fundaro, Giovanni Salti, Dennis Malvin Hernandez Malgapo, Silvia Innocenti
Summary: This review describes the rheological properties of hyaluronic acid (HA) fillers, aiming to help clinicians understand their characteristics and their likely correlation with clinical outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Yuling Hu, Haibin Lu, Xihang Yuan, Zhenyu Yang, Qiuni Gao, Zuoliang Qi
Summary: This study aimed to evaluate the biological response of three different types of fillers and provide theoretical basis for clinical application. The results showed that extracellular matrix had minimal foreign body response, hyaluronic acid had good initial volume effect but lower long-term retention rate than calcium hydroxylapatite, and calcium hydroxylapatite could stimulate neo-collagen formation. This study demonstrated the effectiveness and safety of these fillers and could provide clinical guidance for plastic surgeons.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Otorhinolaryngology
Beata Miaskiewicz, Aleksandra Panasiewicz, Elzbieta Gos, Paulina Krasnodebska, Piotr H. Skarzynski, Agata Szkielkowska
Summary: The severity of glottal gap is associated with a relative risk for reinjection, while factors such as injected material, age, and voice assessment do not seem to impact the likelihood of reoperation in patients with UVFP.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Polymer Science
Stefano Pluda, Cecilia Salvagnini, Anna Fontana, Anna Marchetti, Alba Di Lucia, Devis Galesso, Cristian Guarise
Summary: This study investigates the modulation of hyaluronic acid dermal filler properties, particularly rheology, through process parameters such as modification degree, concentration, and molecular weight. The characterization of commercial hyaluronic acid injectables provides insights into their clinical effects and correlations with in vitro parameters. The findings emphasize the impact of hydrogel composition, rheological properties, and needle size on injectability and fibroblast recognition.
Article
Dermatology
Said Hilton, Konstantin Frank, Michael Alfertshofer, Sebastian Cotofana
Summary: This study aimed to evaluate the safety and effectiveness of lip injections using two hyaluronic acid (HA) fillers manufactured with different gel technologies. Subjects treated with HA(RK) experienced lower intensity of early onset swelling, erythema, and pain/tenderness compared to subjects treated with HA(JUS). Aesthetic improvement, subject satisfaction, and adverse event profiles post-Day 14 were similar between the two filler groups.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Dermatology
Murad Alam, Rohit Kakar, Jeffrey S. Dover, Vishnu Harikumar, Bianca Y. Kang, Hoi Ting Wan, Emily Poon, Derek H. Jones
Summary: In this cohort study, injections with either needles or cannulas for skin fillers were associated with a low risk of intravascular occlusion events. Using cannulas was found to be associated with a lower occlusion risk, and most occlusions resolved without long-term sequelae. Dermatologists may consider using cannulas in filler injection to further minimize the risk of occlusion when appropriate.
Article
Dermatology
Bianca Viscomi, Gladstone Faria, Claudia A. Hernandez, Luiz Perez, Julieta Spada, Victoria De la Fuente, Mariana Muniz
Summary: A well-defined jawline is important for aesthetics and rejuvenation of the jawline can be achieved through minimally invasive injectables. However, choosing the right product among the available options can be challenging. This study presents 4 clinical cases illustrating the Contouring Plus technique for lower face rejuvenation using hyaluronic acid and calcium hydroxylapatite.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Article
Dermatology
Kiyoko Kato, Eiko Inoue
Summary: We report a case of anaphylaxis following the injection of hyaluronic acid fillers and human collagen for facial esthetic improvement. Symptoms included full-body urticaria, gastrointestinal symptoms, facial redness and swelling, and a recurrent nodule in the right tear trough. Treatment with corticosteroids and antihistamine led to a complete recovery. Practitioners should be trained to manage anaphylactic events when using injectables.
JOURNAL OF COSMETIC AND LASER THERAPY
(2022)
Article
Dermatology
Bartosch Nowag, Daniela Schaefer, Thomas Hengl, Niamh Corduff, Kate Goldie
Summary: The study aims to investigate the in vitro macrophage response to two biostimulatory fillers, CaHA and PLLA, and evaluate their inflammatory potential. The findings indicate that CaHA induces a non-inflammatory response, while PLLA triggers the expression of several cytokines involved in inflammation. These results suggest that CaHA and PLLA follow distinct pathways and should be considered individually in terms of mechanism of action.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
