Review
Oncology
Hanzi Huang, Ziyao Fu, Jiang Ji, Jiuzuo Huang, Xiao Long
Summary: This meta-analysis aimed to determine the positive rate of sentinel lymph node biopsy (SLNB) in thin melanoma and summarized the predictive value of different high-risk features. The results showed that microsatellites and ulceration were the strongest predictors for a positive result. It is suggested that thin melanoma patients with these high-risk features should be considered for SLNB.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Alexander C. J. van Akkooi, Dirk Schadendorf, Alexander M. M. Eggermont
Summary: Sentinel lymph node biopsy (SLNB) was introduced in the 1990s to identify patients who may benefit from completion lymph node dissection. SLNB staging has been found to be the best for staging melanoma. Adjuvant systemic therapy and biomarkers are emerging, which might reduce the need for SLNB staging in the future.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Roberto Cirocchi, Giulio Metaj, Michela Cicoletti, Fabrizio Arcangeli, Angelo De Sol, Giulia Poli, Paolo Bruzzone, Sara Gioia, Christos Anagnostou, Fabio Loreti, Simona Francesconi, Linda Ricci, Maria Elena Laurenti, Andrea Capotorti, Marco Artico, Vito D'Andrea, Brandon Michael Henry, Piergiorgio Fedeli, Luigi Carlini
Summary: Studies have shown significant heterogeneity in lymphatic drainage patterns of different cutaneous melanomas, emphasizing the need for multiple imaging evaluations in critical skin areas. The use of fluorescence lymphography with indocyanine green has greatly improved visualization at a microscopic level. It is crucial to combine SPET-CT scans with lymphoscintigraphy preoperatively and perform additional evaluations with indocyanine green intraoperatively to accurately identify sentinel nodes and reduce false negative rates.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Health Care Sciences & Services
Vincenzo Cuccurullo, Marco Rapa, Barbara Catalfamo, Giuseppe Lucio Cascini
Summary: With the advancements in sentinel lymph node technology, histopathological staging can be done using lymphatic mapping and selective lymphadenectomy. Structural imaging techniques like US, CT, and MR allow precise measurement of lymph node volume, which is strongly linked to cancerous involvement. While hybrid imaging has shown higher accuracy than standard imaging in visualizing the sentinel lymph node, it hasn't impacted surgical detection. Non-radiological fields such as ophthalmology and dermatology are introducing alternatives like fluorescence or opto-acoustic imaging. This paper analyzes the advantages and limitations of innovative methods in sentinel lymph node detection, including the continued importance of lymphoscintigraphy techniques.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Oncology
Steven Morrison, Dale Han
Summary: Sentinel lymph node biopsy is crucial in the management of melanoma patients, providing important prognostic data and treatment options for various subtypes. Technological advances have improved the therapeutic potential of SLNB, while the management of patients with a positive SLN has evolved with new treatment options available.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Antonio Tejera-Vaquerizo, Aram Boada, Simone Ribero, Susana Puig, Sabela Paradela, David Moreno-Ramirez, Javier Canueto, Blanca de Unamuno-Bustos, Ana Brinca, Miguel A. Descalzo-Gallego, Simona Osella-Abate, Paola Cassoni, Sebastian Podlipnik, Cristina Carrera, Sergi Vidal-Sicart, Ramon Pigem, Agusti Toll, Ramon Rull, Llucia Alos, Celia Requena, Isidro Bolumar, Victor Traves, Angel Pla, Almudena Fernandez-Orland, Ane Jaka, Maria Teresa Fernandez-Figueras, Nina Anika Richarz, Ricardo Vieira, Rafael Botella-Estrada, Concepcion Roman-Curto, Lara Ferrandiz-Pulido, Nicolas Iglesias-Pena, Carlos Ferrandiz, Josep Malvehy, Pietro Quaglino, Eduardo Nagore
Summary: This study found that SLNB does not improve MSS, DFS, or OS in patients with thin melanoma. However, there is a significant difference in MSS, DFS, and OS between SLN-positive and -negative patients, confirming the value of SLNB as a prognostic procedure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
William A. Zammarrelli, Michelle Greenman, Eric Rios-Doria, Katie Miller, Vance Broach, Jennifer J. Mueller, Emeline Aviki, Kaled M. Alektiar, Robert A. Soslow, Lora H. Ellenson, Vicky Makker, Nadeem R. Abu-Rustum, Mario M. Leitao
Summary: This study compared the survival rates of CS patients who underwent SLN biopsy with those who underwent systematic LND and found no difference in PFS or OS. SLN biopsy can detect nodal metastasis without compromising oncologic outcomes.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Peiyong Li, Ciqiu Yang, Junsheng Zhang, Yitian Chen, Xiaoqi Zhang, Minting Liang, Na Huang, Yilin Chen, Kun Wang
Summary: Sentinel lymph node biopsy can provide survival results equivalent to axillary lymph node dissection for patients with cN0 and T1-2 breast cancer; however, whether it can be performed on patients with T3-4c breast cancer is still controversial.
Article
Oncology
Hanna Kakish, Trisha Lal, Jason E. Thuener, Jeremy S. Bordeaux, Ankit Mangla, Luke D. Rothermel, Richard S. Hoehn
Summary: This study evaluated the utility and prognostic value of sentinel lymph node biopsy (SLNB) in lentigo maligna melanoma (LMM) using large databases. The results showed that SLNB was associated with improved overall survival (OS) but not melanoma-specific survival (MSS) in LMM patients.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Dermatology
Hanna Kakish, James Sun, David X. Zheng, Fasih Ali Ahmed, Mohamedraed Elshami, Alexander W. Loftus, Lee M. Ocuin, John B. Ammori, Richard S. Hoehn, Jeremy S. Bordeaux, Luke D. Rothermel
Summary: This study found that nodal positivity is prognostically significant for very thin melanomas, with an overall rate of 5% in patients who underwent SLNB. Tumor factors such as lymphovascular invasion, ulceration, mitoses, and nodular subtype are associated with higher rates of SLN metastases and should be considered in determining which patients will benefit from SLNB.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Surgery
Tea Stuart Williams, Ben Tallon, Brandon Michael Adams
Summary: The controversy over whether completion lymph node dissection (CLND) should be performed following a positive sentinel lymph node biopsy (SLNB) remains. This study suggests that for a high-risk population with larger metastatic deposits in sentinel lymph nodes and higher rates of non-sentinel node involvement, forgoing CLND in the context of a positive SLNB may put patients at risk.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Oncology
Raghav Tripathi, Karen Larson, Graham Fowler, Dale Han, John T. Vetto, Jeremy S. Bordeaux, Wesley Y. Yu
Summary: This study developed and validated a personalized clinical decision-making tool (ELMO) using nationally representative data to predict lymphatic metastasis in melanoma patients. The tool showed high accuracy and sensitivity in predicting sentinel lymph node biopsy status and could reduce unnecessary procedures. It was externally validated at a large tertiary referral center.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Elena Parvez, Farzin Khosrow-Khavar, Teodora Dumitra, Carolyn Nessim, Ericka Bernard-Bedard, Justin Rivard, Vera Pravong, Sara Wang, Mai-Kim Gervais, Sarkis Meterissian, Sinziana Dumitra
Summary: This study examines real-world practices and outcomes of patients with melanoma sentinel lymph node metastases after the publication of the MSLT-II trial. The findings suggest that although practice patterns have changed, completion lymphadenectomy (CLND) does not reduce the risk of recurrence or mortality.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Che-Chia Hsu, Yi-Hua Liao, Yi-Shuan Sheen
Summary: A retrospective study in Taiwan found that sentinel lymph node biopsy (SLNB) offers survival benefits over nodal observation in early-stage melanoma patients. Among 227 patients who met the SLNB criteria, survival analysis showed significantly improved melanoma-specific survival in the SLNB group. Immediate completion lymph node dissection resulted in significantly longer melanoma-specific survival and distant-metastasis-free survival compared to nodal observation.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Article
Dermatology
Adrienne B. Shannon, Cimarron E. Sharon, Richard J. Straker, Michael J. Carr, Andrew J. Sinnamon, Kita Bogatch, Alexandra Thaler, Nicholas Kelly, John T. Vetto, Graham Fowler, Danielle DePalo, Vernon K. Sondak, John T. Miura, Mark B. Faries, Edmund K. Bartlett, Jonathan S. Zager, Giorgos C. Karakousis
Summary: Sentinel lymph node biopsy is not routinely recommended for T1a cutaneous melanoma due to low risk of positivity. This study identified age, primary tumor location, lymphovascular invasion, and mitotic rate as factors associated with positive sentinel lymph node in T1a melanoma patients.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)