Journal
DERMATOLOGIC CLINICS
Volume 31, Issue 3, Pages 445-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.det.2013.04.009
Keywords
Psoriasis; Autoinflammatory disease; Genetics; Immunopathogenesis; TH cells; TNF-alpha; Cytokines; Inflammasome
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This article presents a summary of the evidence for a link between autoinflammatory diseases and psoriasis. The main concepts regarding the disease state of psoriasis are discussed and these lead to a change in the perspective on the clinical and pathophysiologic nature of psoriasis as a chronic, recurrent disease with important genetically defined features, and an associated or concomitant systemic inflammatory state that involves a multifactorial cellular and molecular network, transforming the old perception of psoriasis as a localized autoimmune skin disease, to one of psoriasis as a systemic inflammatory disease with autoinflammatory features and severe associated comorbid conditions.
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