Journal
DERMATOLOGIC CLINICS
Volume 28, Issue 1, Pages 61-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.det.2009.10.007
Keywords
Collagen XVII; Epidermolysis bullosa; Bullous pemphigoid; Dermal-epidermal junction; Epidermal adhesion
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Funding
- German Research Foundation DFG [HA 5663/1-1]
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Collagen XVII has been identified as having a role in inherited junctional epidermolysis bullosa non-Herlitz (JEB-other, MIM #226650). The role of collagen XVII in both autoimmune and genetic blistering disorders demonstrates its relevance to dermal-epidermal adhesion. Collagen XVII is a major structural component of the hemidesmosome (HD), a highly specialized multiprotein complex that mediates the anchorage of basal epithelial cells to the underlying basement membrane in stratified, pseudostratified, and transitional epithelia. This article examines the genetic and pathological features of collagen XVII.
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