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TREATMENT-RESISTANT DEPRESSION IN ADOLESCENTS: REVIEW AND UPDATES ON CLINICAL MANAGEMENT

DEPRESSION AND ANXIETY (2011)

Journal

DEPRESSION AND ANXIETY

Volume 28, Issue 11, Pages 946-954

Publisher

WILEY

DOI: 10.1002/da.20884

Keywords

depression; adolescent; treatment; treatment-resistant; psychotherapy; antidepressant

Categories

Psychology, Clinical Psychiatry Psychology

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Abstract

Treatment-resistant depression (TRD) in adolescents is prevalent and impairing. We here review the definition, prevalence, clinical significance, risk factors, and management of TRD in adolescents. Risk factors associated with TRD include characteristics of depression (severity, level of hopelessness, and suicidal ideation), psychiatric and medical comorbidities, environmental factors (family conflict, maternal depression, and history of abuse), and pharmacokinetics and other biomarkers. Management options include review of the adequacy of the initial treatment, re-assessment for the above-noted factors that might predispose to treatment resistance, switching antidepressants, and augmentation with medication or psychotherapy. Other modalities, such as electroconvulsive therapy, vagal nerve stimulation, and repetitive transcranial magnetic stimulation, are also reviewed. Depression and Anxiety 28: 946-954, 2011. (C) 2011 Wiley Periodicals, Inc.

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Rana, Zane Rankin, Davide Rasella, David Laith Rawaf, Salman Rawaf, Sarah E. Ray, Christian Aspacia Razo-Garcia, Priscilla Reddy, Robert C. Reiner, Cesar Reis, Marissa B. Reitsma, Giuseppe Remuzzi, Andre M. N. Renzaho, Serge Resnikoff, Satar Rezaei, Mohammad Sadegh Rezai, Antonio L. Ribeiro, Maria Jesus Rios Blancas, Juan A. Rivera, Leonardo Roever, Luca Ronfani, Gholamreza Roshandel, Ali Rostami, Gregory A. Roth, Dietrich Rothenbacher, Ambuj Roy, Nobhojit Roy, George Mugambage Ruhago, Yogesh Damodar Sabde, Perminder S. Sachdev, Nafis Sadat, Mahdi Safdarian, Saeid Safiri, Rajesh Sagar, Amirhossein Sahebkar, Mohammad Ali Sahraian, Haniye Sadat Sajadi, Joseph Salama, Payman Salamati, Raphael de Freitas Saldanha, Hamideh Salimzadeh, Joshua A. Salomon, Abdallah M. Samy, Juan Ramon Sanabria, Parag K. Sancheti, Maria Dolores Sanchez-Nino, Damian Santomauro, Itamar S. Santos, Milena M. Santric Milicevic, Abdur Razzaque Sarker, Nizal Sarrafzadegan, Benn Sartorius, Maheswar Satpathy, Miloje Savic, Monika Sawhney, Sonia Saxena, Mete I. Saylan, Elke Schaeffner, Josef Schmidhuber, Maria Ines Schmidt, Ione J. C. Schneider, Austin E. Schumacher, Aletta E. Schutte, David C. Schwebel, Falk Schwendicke, Mario Sekerija, Sadaf G. Sepanlou, Edson E. Servan-Mori, Azadeh Shafieesabet, Masood Ali Shaikh, Marina Shakh-Nazarova, Mehran Shams-Beyranvand, Heidar Sharafi, Mahdi Sharif-Alhoseini, Sheikh Mohammed Shariful Islam, Meenakshi Sharma, Rajesh Sharma, Jun She, Aziz Sheikh, Mebrahtu Teweldemedhin Shfare, Peilin Shi, Chloe Shields, Mika Shigematsu, Yukito Shinohara, Rahman Shiri, Reza Shirkoohi, Ivy Shiue, Mark G. Shrime, Sharvari Rahul Shukla, Soraya Siabani, Inga Dora Sigfusdottir, Donald H. Silberberg, Diego Augusto Santos Silva, Joao Pedro Silva, Dayane Gabriele Alves Silveira, Jasvinder A. Singh, Lavanya Singh, Narinder Pal Singh, Virendra Singh, Dhirendra Narain Sinha, Abiy Hiruye Sinke, Mekonnen Sisay, Vegard Skirbekk, Karen Sliwa, Alison Smith, Adauto Martins Soares Filho, Badr H. A. Sobaih, Melek Somai, Samir Soneji, Moslem Soofi, Reed J. D. Sorensen, Joan B. Soriano, Ireneous N. Soyiri, Luciano A. Sposato, Chandrashekhar T. Sreeramareddy, Vinay Srinivasan, Jeffrey D. Stanaway, Vasiliki Stathopoulou, Nicholas Steel, Dan J. Stein, Mark Andrew Stokes, Lela Sturua, Muawiyyah Babale Sufiyan, Rizwan Abdulkader Suliankatchi, Bruno F. Sunguya, Patrick J. Sur, Bryan L. Sykes, P. N. Sylaja, Cassandra E. I. Szoeke, Rafael Tabares-Seisdedos, Santosh Kumar Tadakamadla, Andualem Henok Tadesse, Getachew Redae Taffere, Nikhil Tandon, Amare Tariku Tariku, Nuno Taveira, Arash Tehrani-Banihashemi, Girma Temam Shifa, Mohamad-Hani Temsah, Abdullah Sulieman Terkawi, Azeb Gebresilassie Tesema, Dawit Jember Tesfaye, Belay Tessema, J. S. Thakur, Nihal Thomas, Matthew J. Thompson, Taavi Tillmann, Quyen G. To, Ruoyan Tobe-Gai, Marcello Tonelli, Roman Topor-Madry, Fotis Topouzis, Anna Torre, Miguel Tortajada, Bach Xuan Tran, Khanh Bao Tran, Avnish Tripathi, Srikanth Prasad Tripathy, Christopher Troeger, Thomas Truelsen, Derrick Tsoi, Lorainne Tudor Car, Kald Beshir Tuem, Stefanos Tyrovolas, Uche S. Uchendu, Kingsley Nnanna Ukwaja, Irfan Ullah, Rachel Updike, Olalekan A. Uthman, Benjamin S. Chudi Uzochukwu, Pascual Ruben Valdez, Job F. M. van Boven, Santosh Varughese, Tommi Vasankari, Narayanaswamy Venketasubramanian, Francesco S. Violante, Sergey K. Vladimirov, Vasiliy Victorovich Vlassov, Stein Emil Vollset, Theo Vos, Fasil Wagnew, Yasir Waheed, Mitchell T. Wallin, Judd L. Walson, Yafeng Wang, Yuan-Pang Wang, Molla Mesele Wassie, Marcia R. Weaver, Elisabete Weiderpass, Robert G. Weintraub, Jordan Weiss, Kidu Gidey Weldegwergs, Andrea Werdecker, T. Eoin West, Ronny Westerman, Richard G. White, Harvey A. Whiteford, Justyna Widecka, Andrea Sylvia Winkler, Charles Shey Wiysonge, Charles D. A. Wolfe, Yohanes Ayele Wondimkun, Abdulhalik Workicho, Grant M. A. Wyper, Denis Xavier, Gelin Xu, Lijing L. Yan, Yuichiro Yano, Mehdi Yaseri, Nigus Bililign Yimer, Peng Yin, Paul Yip, Biruck Desalegn Yirsaw, Naohiro Yonemoto, Gerald Yonga, Seok-Jun Yoon, Marcel Yotebieng, Mustafa Z. Younis, Chuanhua Yu, Vesna Zadnik, Zoubida Zaidi, Maysaa El Sayed Zaki, Sojib Bin Zaman, Mohammad Zamani, Zerihun Menlkalew Zenebe, Maigeng Zhou, Jun Zhu, Stephanie R. M. Zimsen, Ben Zipkin, Sanjay Zodpey, Liesl Joanna Zuhlke, Christopher J. L. Murray, Rafael Lozano

LANCET (2018)

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Article Psychiatry

Correlates of bullying and its relationship with psychiatric disorders in Lebanese adolescents

Fadi Halabi, Lilian Ghandour, Racha Dib, Pia Zeinoun, Fadi T. Maalouf

PSYCHIATRY RESEARCH (2018)

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Article Clinical Neurology

Neuropsychological Findings in Hamamy Syndrome: A Clinical Case Report

Cynthia Roukoz, Rama Kanj, Fadi T. Maalouf, Pia Zeinoun

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY (2019)

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Article Psychiatry

Suicidality among Lebanese adolescents: Prevalence, predictors and service utilization

Evelyne Baroud, Lilian A. Ghandour, Loay Alrojolah, Pia Zeinoun, Fadi T. Maalouf

PSYCHIATRY RESEARCH (2019)

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Article Behavioral Sciences

Association between substance use disorders and self- and other-directed aggression: An integrated model approach

Elias Ghossoub, Salim M. Adib, Fadi T. Maalouf, Ghada E. -H. Fuleihan, Hani Tamim, Ziad Nahas

AGGRESSIVE BEHAVIOR (2019)

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Correction Clinical Neurology

Do sub-syndromal manic symptoms influence outcome in treatment resistant depression in adolescents? A latent class analysis from the TORDIA study (vol 138, pg 86, 2012)

F. T. Maalouf, G. Porta, B. Vitiello, G. Emslie, T. Mayes, G. Clarke, K. D. Wagner, J. R. Asarnow, A. Spirito, M. Keller, B. Birmaher, N. Ryan, W. Shamseddeen, S. Iyengar, D. Brent

JOURNAL OF AFFECTIVE DISORDERS (2019)

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Review Psychiatry

The Arab Region's Contribution to Global Mental Health Research (2009-2018): A Bibliometric Analysis

Pia Zeinoun, Elie A. Akl, Fadi T. Maalouf, Lokman I. Meho

FRONTIERS IN PSYCHIATRY (2020)

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Article Psychiatry

Mental health research in response to the COVID-19, Ebola, and H1N1 outbreaks: A comparative bibliometric analysis

Fadi T. Maalouf, Bernadette Mdawar, Lokman Meho, Elie A. Akl

Summary: Bibliometric analyses revealed that there is a greater output of mental health research related to COVID-19 compared to Ebola and H1N1. The majority of documents were published by authors from high-income countries, with less international collaboration and funding reported.

JOURNAL OF PSYCHIATRIC RESEARCH (2021)

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Article Psychiatry

Psychopathology in Children and Adolescents in Lebanon Study (PALS): a national household survey

Fadi T. Maalouf, Loay Alrojolah, Leyla Akoury-Dirani, Marc Barakat, David Brent, Martine Elbejjani, Wael Shamseddeen, Lilian A. Ghandour

Summary: This study is the first to investigate the mental health status of children and adolescents in Lebanon on a national level and estimate the prevalence of psychiatric disorders. The results show a high prevalence of psychiatric symptoms among Lebanese children and adolescents, with a concerning treatment gap. School-based primary prevention programs and screening in primary care settings are crucial for early detection and management of psychiatric symptoms, as well as the prevention of psychiatric disorders.

SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY (2022)

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Article Public, Environmental & Occupational Health

Effectiveness of a Preventive Parenting Program Combining Attachment and Behavioral Approaches in an Arab Context: a Cluster-Based Randomized Control Trial

Leyla Akoury Dirani, Wael Shamseddeen, Linda Bou Ali, Martine Elbejjani, Hala Raad, Najat Fadlallah, Fadi Maalouf

Summary: This study aimed to evaluate the effectiveness of a preventive parenting program designed for the local cultural context in Lebanon. Despite positive feedback from mothers who attended the sessions, no significant effects were detected, possibly due to the program design, expected outcomes, and characteristics of the participants. Further research is needed to address these limitations and explore the potential impact of the program.

PREVENTION SCIENCE (2022)

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Correction Psychiatry

Psychopathology in Children and Adolescents in Lebanon Study (PALS): a national household survey (vol 57, pg 761, 2022)

Fadi T. Maalouf, Loay Alrojolah, Leyla Akoury-Dirani, Marc Barakat, David Brent, Martine Elbejjani, Wael Shamseddeen, Lilian A. Ghandour

SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY (2022)

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Article Public, Environmental & Occupational Health

Building Emotional Resilience in Youth in Lebanon: a School-Based Randomized Controlled Trial of the FRIENDS Intervention

Fadi T. Maalouf, Loay Alrojolah, Lilian Ghandour, Rima Afifi, Leyla Akoury Dirani, Paula Barrett, Rima Nakkash, Wael Shamseddeen, Farah Tabaja, Courtney M. Yuen, Anne E. Becker

PREVENTION SCIENCE (2020)

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Review Psychiatry

Mental health research in the Arab region: challenges and call for action

Fadi T. Maalouf, Bibi Alamiri, Samir Atweh, Anne E. Becker, Majda Cheour, Hala Darwish, Lilian A. Ghandour, Suhaila Ghuloum, Mouin Hamze, Elie Karam, Brigitte Khoury, Samia J. Khoury, Ali Mokdad, Lokman I. Meho, Tarek Okasha, Geoffrey M. Reed, Eman Sbaity, Pia Zeinoun, Elie A. Akl

LANCET PSYCHIATRY (2019)

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Article Health Care Sciences & Services

Contextual challenges and solutions to undertaking a household adolescent mental health survey in a developing country

Lilian A. Ghandour, Al Amira S. Shehab, Pia Zeinoun, Lucy Tavitian, Fadi Halabi, Fadi T. Maalouf

EASTERN MEDITERRANEAN HEALTH JOURNAL (2018)

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