Review
Psychiatry
Louise Destree, Mary-Ellen E. Brierley, Lucy Albertella, Laura Jobson, Leonardo F. Fontenelle
Summary: This study conducted a systematic review on the relationships between childhood trauma and obsessive-compulsive symptoms (OCS) severity. The results showed a significant relationship between exposure to childhood trauma and OCS severity in both clinical and non-clinical populations. It was also found that a range of childhood trauma types, rather than a single type, was associated with OCD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Editorial Material
Clinical Neurology
Trevor. W. Robbins
Summary: This scientific commentary discusses the research conducted by Kim et al. on the unbalanced fronto-pallidal neurocircuit underlying set shifting in patients with obsessive-compulsive disorder, published in the journal Brain.
Article
Clinical Neurology
Puyu Li, Jiayue Cheng, Qiumeng Gu, Pei Wang, Zhiguang Lin, Qing Fan, Jue Chen, Zhen Wang
Summary: The study found that unmedicated OCD patients showed significantly lower mBDNF, proBDNF plasma levels, and M/P ratio compared to healthy controls. Positive associations were found between stress and early trauma, and between early trauma and M/P ratio, while negative correlations included proBDNF and stress, as well as proBDNF and early trauma.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Yang Wang, Ang Hong, Weili Yang, Zhen Wang
Summary: This study used network analysis to explore the relationship between childhood trauma, personality, perceived stress, and symptom dimensions in OCD patients and healthy individuals. The results showed that emotional abuse was significant in both networks, while perceived stress was more significant in the patient network and had stronger associations with obsession.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Psychiatry
Leonardo F. Fontenelle, Lucy Albertella, Mary-Ellen Brierley, Emma M. Thompson, Louise Destree, Sam R. Chamberlain, Murat Yucel
Summary: This study investigated the deterioration of symptoms of obsessive-compulsive and related disorders (OCRDs) during the COVID-19 pandemic, finding that factors such as being female, experiencing more COVID-19 related stressful events, and having higher compulsivity traits predicted worsened symptoms during the pandemic. Identifying a pre-pandemic profile of individuals most at risk of symptom deterioration may be valuable for future preventative initiatives related to COVID-19 or other communicable diseases. Future studies should follow up on these findings longitudinally.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychology, Clinical
Caitlin. M. M. Pinciotti
Summary: Despite the lack of formal treatment recommendations, existing research and theory can guide the assessment, case conceptualization, and treatment for co-occurring OCD and PTSD. This article provides clinically useful suggestions and offers case examples to illustrate their application.
CLINICAL PSYCHOLOGY-SCIENCE AND PRACTICE
(2023)
Review
Psychology, Clinical
Behrang Mahjani, Katharina Bey, Julia Boberg, Christie Burton
Summary: Obsessive-compulsive disorder (OCD) is a heritable, polygenic disorder with contributions from both common and rare genetic variants. Genetics play an important role in the susceptibility to OCD, with discrete OCD symptom dimensions having both shared and unique genetic risks. Genome-wide studies show that OCD shares genetic risk with its comorbid conditions.
PSYCHOLOGICAL MEDICINE
(2021)
Review
Clinical Neurology
Valerie La Buissonniere-Ariza, Kate Fitzgerald, Avner Meoded, Laurel L. Williams, Gary Liu, Wayne K. Goodman, Eric A. Storch
Summary: The systematic review of functional MRI studies in youths with negative valence disorders suggests that variations in neural functioning may impact response to CBT. However, the overall weak to moderate quality and limited number of studies, as well as the heterogeneity in study designs and results, considerably restrict the conclusions that can be drawn from this literature.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Prerika Sharma, Maria C. Rosario, Ygor A. Ferrao, Lucy Albertella, Euripedes C. Miguel, Leonardo F. Fontenelle
Summary: This study investigated the characteristics of patients with comorbid generalized anxiety disorder (GAD) and obsessive-compulsive disorder (OCD), and found that comorbid GAD was associated with an increased number of avoidant behaviors and greater severity of anxiety.
PSYCHIATRY RESEARCH
(2021)
Article
Psychology, Clinical
Matthew M. Yalch, Margaret Froehlich
Summary: This study examined the differential associations between trauma with varying levels of betrayal and OCPD pathology using a Bayesian approach to structural equation modeling. Results showed that interpersonal trauma high in betrayal was uniquely associated with OCPD in men. These findings have important implications for future research on the influence of trauma and personality pathology, as well as for the treatment of OCPD specifically.
PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY
(2023)
Article
Psychology, Multidisciplinary
Faranak Kadivari, Mahmoud Najafi, Vahid Khosravani
Summary: This study found that childhood maltreatment has both direct and indirect effects on obsessive-compulsive symptoms, with the indirect effect mediated by the behavioral inhibition system. The findings highlight the role of the behavioral inhibition system in linking childhood maltreatment to obsessive-compulsive symptomology.
CURRENT PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Katherine Parkin, Shanquan Chen, Marjan Biria, James Plaistow, Helen Beckwith, Isaac Jarratt-Barnham, Nuria Segarra, Yulia Worbe, Naomi A. Fineberg, Rudolf N. Cardinal, Trevor W. Robbins, Emilio Fernandez-Egea
Summary: Obsessive-compulsive symptoms (OCS) commonly occur in patients treated with clozapine and can significantly affect subjective wellbeing. This study found that OCS severity had a negative impact on wellbeing scores, independent of depressive and psychotic symptoms. However, OCS did not impair general functioning. Obsessional thinking and hoarding behavior, rather than compulsions, were specifically associated with decreased wellbeing, possibly due to the nature of the compulsions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Shruti S. Kinkel-Ram, William Grunewald, Shelby N. Ortiz, Joshua M. Magee, April R. Smith
Summary: This study revealed a bidirectional longitudinal relationship between eating disorders and obsessive-compulsive disorder, particularly in terms of cognitive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Shruti S. Kinkel-Ram, William Grunewald, Shelby N. Ortiz, Joshua M. Magee, April R. Smith
Summary: The study found a bidirectional, longitudinal relationship between symptoms of eating disorders (ED) and obsessive-compulsive disorder (OCD), particularly in terms of cognitive symptoms. However, this longitudinal association was only present at certain time points.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Pharmacology & Pharmacy
Irena Smaga, Malgorzata Frankowska, Malgorzata Filip
Summary: N-acetylcysteine (NAC) is a well-known mucolytic agent that has shown beneficial effects on different psychiatric disorders. It exerts its effects through regulating neurotransmitters, oxidative balance, and inflammatory mediators. While preclinical studies have shown positive results, further research is needed to establish the clinical efficacy of NAC for psychiatric disorders.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)