Article
Clinical Neurology
Xiang Lu, Jian-Feng Zhang, Feng Gu, Hong-Xing Zhang, Meng Zhang, Hai-San Zhang, Rui-Ze Song, Ya-Chen Shi, Kun Li, Bi Wang, Zhi-Jun Zhang, Georg Northoff
Summary: The study revealed a significant reduction in task-related global signal correlation in the default-mode network (DMN) of patients with major depressive disorder (MDD) specifically during fast processing of negative emotions, suggesting a link with psychomotor retardation.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Multidisciplinary
Maria Elena Garrote-Camara, Ivan Santolalla-Arnedo, Regina Ruiz de Vinaspre-Hernandez, Vicente Gea-Caballero, Teresa Sufrate-Sorzano, Pablo del Pozo-Herce, Rebeca Garrido-Garcia, Esther Rubinat-Arnaldo, Raul Juarez Vela
Summary: This study evaluated the psychometric properties of the Spanish version of the ABS Corrigan scale in patients with severe mental disorders. The results showed acceptable reliability and validity of the three dimensions, consistent with the original version.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychiatry
Katherine S. F. Damme, Jadyn S. Park, Sebastian Walther, Teresa Vargas, Stewart A. Shankman, Vijay A. Mittal
Summary: This study found that early developmental motor delays are associated with psychotic-like experiences and depression symptoms, as well as familial risk. Adolescent motor signs showed unique patterns of relationships to symptoms and familial risk, suggesting the presence of distinct forms of psychopathology. Motor network connectivity was related to symptoms and familial risk.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Clinical Neurology
Yi-Hsien Chen, Wei-Ming Wang, I-Hsun Li, Hui-Han Kao, Chin-Bin Yeh, Li-Ting Kao
Summary: The study provides evidence that MDD is an independent risk factor for developing psoriasis, with a higher risk in males. Further investigation is needed to explore the underlying pathological mechanisms in the psychiatric field.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychology, Clinical
Florian Wuethrich, Carver B. Nabb, Vijay A. Mittal, Stewart A. Shankman, Sebastian Walther
Summary: Psychomotor slowing is a key feature of depressive disorders. A novel meta-analysis on actigraphically measured slowing in depression was conducted, and the results showed that patients with depression have lower activity levels. This study provides important evidence for using actigraphy to assess and stage depressive disorders.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Renee J. Thompson, Daphne Y. Liu, Ella Sudit, Matt Boden
Summary: Individuals with current major depressive disorder (MDD) or in remission exhibit low levels of negative and positive emotion differentiation, indicating that diminished emotion differentiation may be a stable characteristic of depressive disorders and a potential target for future prevention efforts.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Tomiki Sumiyoshi, Tatsuya Hoshino, Izumi Mishiro, Lene Hammer-Helmich, Holly Ge, Yoshiya Moriguchi, Keita Fujikawa, Jovelle L. Fernandez
Summary: Early improvement in depressive symptoms predicts better cognitive outcomes in patients with Major Depressive Disorder (MDD). Grouping patients by mood and cognition status in early stages of antidepressant treatments may help improve long-term functional outcomes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Jin Liu, Yiming Fan, Ling-Li Zeng, Bangshan Liu, Yumeng Ju, Mi Wang, Qiangli Dong, Xiaowen Lu, Jinrong Sun, Liang Zhang, Hua Guo, Futao Zhao, Weihui Li, Li Zhang, Zexuan Li, Mei Liao, Yan Zhang, Dewen Hu, Lingjiang Li
Summary: The study found differences in brain functional connectivity between MDD patients with FED and RD, and these differences were associated with the severity of the illness and its duration. The degree of functional connectivity did not significantly change after treatment, indicating that the progression of depression is a gradual process.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Laura Orsolini, Simone Pompili, Silvia Tempia Valenta, Virginio Salvi, Umberto Volpe
Summary: This study reviewed the literature on the association between C-Reactive Protein (CRP) and depression. Evidence suggested dysregulation in the inflammation system in individuals with depression, with higher blood CRP levels being associated with greater symptom severity and worse treatment response. Some depressed patients showed a low-grade inflammatory state, suggesting a distinct subgroup within major depressive disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Yang Yang, Qian Cui, Fengmei Lu, Yajing Pang, Yuyan Chen, Qin Tang, Di Li, Ting Lei, Zongling He, Shan Hu, Jiaxin Deng, Huafu Chen
Summary: The study revealed abnormal functional connectivity patterns of DMN subsystems in patients with bipolar disorder during major depressive episodes, and these abnormalities were associated with high levels of pessimism, highlighting the importance of pathological mechanisms in this disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Clinical
Roy H. Perlis, Katherine Ognyanova, Alexi Quintana, Jon Green, Mauricio Santillana, Jennifer Lin, James Druckman, David Lazer, Matthew D. Simonson, Matthew A. Baum, Hanyu Chwe
Summary: The study found that social support factors are associated with reduced risk of major depressive symptoms, with religious service attendance and trust in others showing greater protective effects among women than men.
DEPRESSION AND ANXIETY
(2021)
Article
Psychology, Multidisciplinary
Thiemo Knaust, Matthias B. D. Siebler, Dagmar Tarnogorski, Philipp Skiberowski, Helge Hoellmer, Christian Moritz, Holger Schulz
Summary: This study compared hippocampal subfield volumes among soldiers with PTSD, MDD, and AdjD using routine clinical data. The results showed no significant volume differences between these stress-related mental disorders.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Clinical Neurology
Yingying Yin, Chunming Xie, Haisan Zhang, Hongxing Zhang, Zhijun Zhang, Yonggui Yuan
Summary: The COMT Met allele influences the CBF changes in MDD patients, particularly in the left precuneus and right caudate. The CBF of the prefrontal cortex is positively correlated with the severity of PMR.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Clinical Neurology
Chengwen Liu, Emily L. Belleau, Daifeng Dong, Xiaoqiang Sun, Ge Xiong, Diego A. Pizzagalli, Randy P. Auerbach, Xiang Wang, Shuqiao Yao
Summary: This study investigated dynamic functional connectivity alterations in unmedicated individuals with current or past major depressive disorder (MDD) using co-activation pattern analyses. The results showed that individuals with current MDD had increased dominance of state 1 (default mode network) and decreased dominance of state 4 (frontal-parietal network), while individuals with past MDD had increased entries of state 4. Both MDD groups showed increased FPN-to-DMN transition frequency and a reduction in state 3 (visual attention, somatosensory, limbic networks) compared to healthy controls.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
John J. Soderholm, J. Lumikukka Socada, Tom Rosenstrom, Jesper Ekelund, Erkki Isometsa
Summary: The course of illness differs between MDD, BD, and BPD patients. Bipolar depressive patients have an alternating course and the shortest time to first remission. The severity of BPD may predict the duration of remission from depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)