Article
Materials Science, Ceramics
Renan Belli, Katrin Hurle, Jana Schuerrlein, Anselm Petschelt, Katharina Werbach, Herwig Peterlik, Torsten Rabe, Bjoern Mieller, Ulrich Lohbauer
Summary: This study revised the relationship between fracture toughness and Yttria content in modern zirconia ceramics by evaluating 10 modern Y2O3-stabilized zirconia materials. The study found an inverse power-law behavior between K-Ic and Y2O3 content, as well as a linear relationship between K-Ic and the fraction of the transformable t-phase within a certain range of volume percentage.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2021)
Article
Chemistry, Physical
Hu Tang, Yong Cheng, Xiaohong Yuan, Kai Zhang, Alexander Kurnosov, Zhen Chen, Wenge Xiao, Henrik S. Jeppesen, Martin Etter, Tao Liang, Zhidan Zeng, Fei Wang, Hongzhan Fei, Lin Wang, Songbai Han, Ming-Sheng Wang, Guang Chen, Howard Sheng, Tomoo Katsura
Summary: Exceptional toughening in oxide glasses has been achieved via paracrystallization, resulting in the enhancement of crystal-like medium-range order structure. This discovery provides possibilities for the design of more resilient glass materials. The paracrystalline oxide glasses display superior toughness, surpassing any other reported bulk oxide glasses, potentially due to the excitation of multiple shear bands caused by a stress-induced inverse transformation from the paracrystalline to amorphous states, revealing plastic deformation characteristics.
Article
Nanoscience & Nanotechnology
Taylan Ors, Fanny Gouraud, Vincent Michel, Marc Huger, Nathalie Gey, Jean-Sebastien Micha, Olivier Castelnau, Rene Guinebretiere
Summary: Pure zirconia undergoes two solid-state phase transitions from the liquid state to room temperature, with the last transition being martensitic and leading to large volume variations and shear strains. Elastic and inelastic behaviors of zirconia-based materials are strongly influenced by the strain and stress fields induced by this transition. The strains map at the crystal scale in zirconia polycrystals shows huge fluctuations in deviatoric elastic strain, with associated stress levels in the range of 5 GPa and stress gradients of 1 GPa μm(-1).
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2021)
Article
Multidisciplinary Sciences
Ulrich Burkhardt, Aimo Winkelmann, Horst Borrmann, Andreea Dumitriu, Markus Koenig, Grzegorz Cios, Yuri Grin
Summary: This study investigates the assignment of enantiomorphs using diffraction methods for X-rays and electrons. By comparing experimental and simulated Kikuchi patterns, enantiomorphs in polycrystalline materials of beta-Mn and Pt2Cu3B can be accurately determined.
Article
Nanoscience & Nanotechnology
Solomon Hanson Duntu, Kenneth Hukpati, Iftikhar Ahmad, Mohammad Islam, Solomon Boakye-Yiadom
Summary: This study aims to enhance the fracture toughness of monolithic alumina ceramic by manipulating its microstructure with nanostructured materials. The results demonstrate that the addition of zirconia, graphene, and carbon nanotubes can significantly improve the fracture toughness and bending strength of the composites. Mechanisms such as pull-outs, crack arrest, and crack bridging by graphene and carbon nanotubes contribute to these enhancements.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Materials Science, Ceramics
Solomon Hanson Duntu, Francis Tetteh, Iftikhar Ahmad, Mohammad Islam, Solomon Boakye-Yiadom
Summary: The study investigates the structure and properties of Al2O3-graphene and Al2O3-ZrO2 composites, with different wt% compositions, fabricated via hot-pressing. The addition of ZrO2 resulted in a reduction or increase in the grain size of the alumina matrix, depending on the wt%. X-ray diffraction analysis revealed different crystal structures in the samples. The inclusion of graphene and ZrO2 significantly improved fracture toughness and hardness of the composites due to fine-grained microstructures and toughening mechanisms.
CERAMICS INTERNATIONAL
(2021)
Article
Physics, Multidisciplinary
Andres Montoya-Castillo, Michael S. Chen, Sumana L. Raj, Kenneth A. Jung, Kasper S. Kjaer, Tobias Morawietz, Kelly J. Gaffney, Tim B. van Driel, Thomas E. Markland
Summary: Time-resolved scattering experiments can image materials at the molecular scale with femtosecond time resolution. However, there are limitations in disordered media. In this study, a theoretical framework is introduced to predict and interpret experiments combining optically induced anisotropy and time-resolved scattering, and its accuracy is verified through chloroform experiments and simulations.
PHYSICAL REVIEW LETTERS
(2022)
Article
Chemistry, Physical
Cody Kunka, Apaar Shanker, Elton Y. Chen, Surya R. Kalidindi, Remi Dingreville
Summary: Traditional diffraction techniques are limited by the difficulty of decoding desired material information, but using machine learning and feature identification can more comprehensively and accurately predict structural information.
NPJ COMPUTATIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Samuel R. Baird, Emanuel Hupf, Ian C. Watson, Michael J. Ferguson, Eric Rivard
Summary: A tetramer shaped indium(I) organometallic compound supported by anionic N-heterocyclic olefin ligands is reported. The monomeric unit of this compound shows both Lewis acidic and basic properties at indium, and the steric profile of the N-heterocyclic olefin ligand enables the isolation of a rare monomeric imide.
CHEMICAL COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Joao V. Campos, Isabela R. Lavagnini, Viviana Avila, Bola Yoon, Sanjit Ghose, Rishi Raj, Eliria M. J. A. Pallone, Lilian M. Jesus
Summary: This study investigates the Arrhenius behavior of electrical conductivity during flash sintering of 3 mol% yttria stabilized zirconia. Total conductivity was found to follow an Arrhenius-like equation in both dense and green samples, with non-linearity related to furnace temperature. A change in activation energy for conduction prior to the flash event was observed and discussed.
SCRIPTA MATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Shuo Feng, Rajesh Kumar Singh, Yucheng Fu, Zhuo Li, Yulong Wang, Jie Bao, Zhijie Xu, Guosheng Li, Cassidy Anderson, Lili Shi, Yuehe Lin, Peter G. Khalifah, Wei Wang, Jun Liu, Jie Xiao, Dongping Lu
Summary: In this study, a simple strategy was demonstrated for constructing low-tortuosity through-pores in both vertical and planar directions of electrodes by casting large particles into single-particle-layer electrodes. Through multi-scale characterizations and simulations, correlations between material/electrode structures, electrolyte permeability, polysulfide migration, and sulfur reactions were elucidated. The high-loading and dense sulfur cathode fabricated by this method delivers a high specific capacity at a very low electrolyte/sulfur ratio.
ENERGY & ENVIRONMENTAL SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Olivier Thomas, Stephane Labat, Thomas Cornelius, Marie-Ingrid Richard
Summary: X-ray imaging of strains has made impressive progress recently, with improved resolution and optical elements. Development of new detectors has revolutionized measurement strategies. The introduction of a new accelerator ring concept has significantly increased brightness and coherent flux. In the next decade, fast three-dimensional imaging methods will emerge to track the evolution of strains in materials.
Article
Engineering, Mechanical
J. Aleksejev, M. Williamson, J. E. Huber, O. Magdysyuk, S. Michalik, T. J. Marrow
Summary: This study successfully observed and quantified the development of wear through the combination of X-ray CT and diffraction, providing a comprehensive analysis of the wear process.
TRIBOLOGY INTERNATIONAL
(2022)
Review
Chemistry, Multidisciplinary
Ha L. Nguyen
Summary: Reticular chemistry of covalent organic frameworks (COFs) focuses on linking discrete organic building units into extended structures through strong covalent bonds. Over the past decade, there has been rapid development in COF chemistry in terms of structural diversity and applications. Understanding the concept of reticular chemistry is essential for researching COFs and correlating their geometric structures and practical applications.
Article
Chemistry, Physical
Iztok Naglic, Blaz Leskovar, Zoran Samardzija, Bostjan Markoli
Summary: This study investigated the influence of gallium addition on the phases formed in Al-Mn alloys during casting, revealing that an increase in gallium content led to the formation of IQCs and DQCs in the alloys. Microanalysis showed that IQCs contained more gallium and less manganese compared to DQCs.
Article
Chemistry, Multidisciplinary
Despoina Eleftheriadou, Rachael E. Evans, Emily Atkinson, Ahmed Abdalla, Francesca K. H. Gavins, Ashleigh S. Boyd, Gareth R. Williams, Jonathan C. Knowles, Victoria H. Roberton, James B. Phillips
Summary: This study developed a novel approach for protecting cells implanted into the central nervous system by using dual-layer alginate beads. The beads act as a sustained physical barrier, preventing host immune responses while allowing exchange of small molecules. Additionally, an immunosuppressant, FK506, was incorporated into the outer layer of the beads, enabling prolonged release to further protect the implanted cells. This research has the potential to be an effective treatment method in CNS cell delivery.
Article
Nanoscience & Nanotechnology
K. D. Patel, L. Barrios Silva, Y. Park, T. Shakouri, Z. Keskin-Erdogan, P. Sawadkar, K. J. Cho, J. C. Knowles, D. Y. S. Chau, H-W Kim
Summary: Glaucoma, a chronic eye disease associated with high intraocular pressure, poses challenges in drug treatment due to ocular barriers. Various carrier-drug formulations have shown improvements in ocular penetration, drug release, and lowering intraocular pressure. These delivery systems can be administered through different routes to target damaged sites, providing an effective treatment strategy for glaucoma.
MATERIALS TODAY NANO
(2022)
Article
Biochemistry & Molecular Biology
Ji-Myung Choi, Huong Thu Vu, Seong-Jin Shin, Jun-Yong Ahn, You-Jin Kim, Sol Song, Mi-Ran Han, Jun-Haeng Lee, Jong-Soo Kim, Jonathan C. Knowles, Hae-Hyoung Lee, Ji-Sun Shin, Jong-Bin Kim, Jung-Hwan Lee
Summary: A water-soluble root-filling material incorporated with NaI showed adequate physicochemical properties and low osteoclast formation compared to its iodoform counterpart.
Article
Pharmacology & Pharmacy
Se-Jung Bang, Soo-Kyung Jun, Yu-Jin Kim, Jun-Yong Ahn, Huong Thu Vu, Nandin Mandakhbayar, Mi-Ran Han, Jun-Haeng Lee, Jong-Bin Kim, Jong-Soo Kim, Jonathan C. Knowles, Hye-Sung Kim, Hae-Hyoung Lee, Ji-Sun Shin, Jung-Hwan Lee
Summary: Combining copper-doped bioactive glass nanoparticles (CuBGns) with silver diamine fluoride (SDF) enhances viscosity, increases deposition of silver and fluoride, improves antibacterial effects, and reduces cell toxicity.
Article
Biotechnology & Applied Microbiology
Suk-Min Hong, Ji-Young Yoon, Jae-Ryung Cha, Junyong Ahn, Nandin Mandakhbayar, Jeong Hui Park, Junseop Im, Gangshi Jin, Moon-Young Kim, Jonathan C. Knowles, Hae-Hyoung Lee, Jung-Hwan Lee, Hae-Won Kim
Summary: The study reports a novel polycaprolactone-based polyurethane copolymer with hyperelasticity, shape-memory, and ultra-cell adhesion properties, which is considered a potential tissue-regenerative biomaterial, especially for minimally invasive surgery.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Review
Engineering, Biomedical
Jae Hee Park, Seung Bin Jo, Jung-Hwan Lee, Hae-Hyoung Lee, Jonathan C. Knowles, Hae-Won Kim
Summary: Rigidity of materials and extracellular matrix plays a crucial role in controlling cell behaviors and pathophysiological phenomena. Research on 2D materials has revealed the impact of matrix biophysical cues on cellular events, while recent findings in 3D environments highlight the importance of dynamically changing rigidity in tissue repair and disease progression. These studies provide insights for therapeutic targeting and the design of implantable materials.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Ceramics
Ensanya A. Abou Neel, S. Soumya, Sharon R. Oyhanart, Jonathan C. Knowles, Shams A. M. Issa, Ghada Almisned, H. O. Tekin
Summary: The incorporation of Fe2O3 into P2O5-CaO-Na2O glasses enhances their biocompatibility and gamma-ray absorption characteristics, making them suitable for medical and dental applications.
CERAMICS INTERNATIONAL
(2023)
Article
Engineering, Environmental
Yu-Meng Li, Kapil D. Patel, Yoon-Koo Han, Suk-Min Hong, Yu-Xuan Meng, Hae-Hyoung Lee, Jeong Hui Park, Jonathan C. Knowles, Jung Keun Hyun, Jung-Hwan Le, Hae-Won Kim
Summary: Diseased or injured nervous systems have limited self-repair and regenerative capability, leading to lifelong disability and even death. Biomaterial scaffolds with specific properties, such as electroconductivity, can guide the selective differentiation of neural stem/progenitor cells (NSPCs) into neurons and oligodendrocytes. Electroconductive and mechano-competent scaffolds made of shape-memory polyurethane-polycaprolactone (PUCL) nanofibers and carbon nanotubes (CNTs) were prepared and showed promising potential for neural tissue regeneration.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Soo-Jin Chang, Yu-Jin Kim, Huong Thu Vu, Ji-Myung Choi, Jeong-Hui Park, Seong-Jin Shin, Khandmaa Dashnyam, Jonathan C. Knowles, Hae-Hyoung Lee, Soo-Kyung Jun, Mi-Ran Han, Joon-Haeng Lee, Jong-Soo Kim, Ji-Sun Shin, Jong-Bin Kim, Jung-Hwan Lee
Summary: This study investigated the effects of different viscosities of silicone oil on the properties of a sodium iodide paste. Six different paste groups were created and evaluated using various parameters. The D30L group showed superior outcomes compared to the conventional iodoform group, including reduced osteoclast formation. The optimized viscosity of the sodium iodide paste (D30L) may lead to favorable outcomes when used in primary teeth.
Article
Pharmacology & Pharmacy
Yu-Ji Jang, Yu-Jin Kim, Huong Thu Vu, Jeong-Hui Park, Seong-Jin Shin, Khandmaa Dashnyam, Jonathan C. C. Knowles, Hae-Hyoung Lee, Soo-Kyung Jun, Mi-Ran Han, Joon-Haeng Lee, Jong-Soo Kim, Jong-Bin Kim, Jung-Hwan Lee, Ji-Sun Shin
Summary: Calcium silicate-based cement (CSC) is widely used in dentistry due to its excellent biocompatibility, sealing ability, and antibacterial activity. This study compared four commercial CSCs and found that premixed CSCs had improved physical properties, with ECPR exhibiting the highest antibacterial properties. However, there were no significant differences in biological properties at 12.5% dilution. Further investigation is needed for clinical situations.
Review
Pharmacology & Pharmacy
Xiaohan Ma, Jonathan C. Knowles, Alessandro Poma
Summary: Molecular imprinting technology has made significant advancements in the design and production of MIP nanoparticles (MIP NPs) as antibody substitutes. However, its overall sustainability and biodegradability have been questioned. This review aims to examine the production and purification strategies of MIP NPs from a sustainability and waste management perspective.
Article
Biochemistry & Molecular Biology
Mohammad B. Aljaber, Fiona Verisqa, Zalike Keskin-Erdogan, Kapil D. Patel, David Y. S. Chau, Jonathan C. Knowles
Summary: Approximately half of an adult human's body weight is made up of muscles. The source and bloom number of gelatin have been found to have an impact on the mechanical properties and biological activities of GelMA hydrogels.
Article
Chemistry, Multidisciplinary
Ghada Alrabeah, Jonathan C. Knowles, Haralampos Petridis
Summary: The improved peri-implant bone response seen with the platform-switching concept may be due to the reduced release of metal ions from the implant-abutment surfaces. This study investigated the effect of different implant-abutment couplings on osteoblasts' function and found that platform-matched couplings resulted in higher rates of cell apoptosis and upregulation of genes related to bone resorption. These adverse biological responses may be associated with the increased release of metal ions from platform-matched couplings, indicating the potential role of corrosion products in crestal bone loss around dental implants.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Farzad Foroutan, Benjamin A. Kyffin, Athanasios Nikolaou, Jorge Merino-Gutierrez, Isaac Abrahams, Nasima Kanwal, Jonathan C. Knowles, Andrew J. Smith, Glen J. Smales, Daniela Carta
Summary: Mesoporous glasses with high surface area and extended porosity are ideal for controlled release of therapeutic ions and molecules. In this study, mesoporous phosphate-based glasses doped with copper ions were synthesized and their structures were characterized. The copper-doped glasses showed significant antibacterial properties and potential for controlled delivery of antibacterial ions.
Meeting Abstract
Gastroenterology & Hepatology
Elisabetta Caon, Philipp Schwabl, Luca Frenguelli, Hannah Evans, Margarita Papatheodoridi, Zalike Keskin-Erdogan, Nicola Mordan, Jonathan Knowles, Giuseppe Mazza, Massimo Pinzani, Krista Rombouts
JOURNAL OF HEPATOLOGY
(2023)
