Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 38, Issue 3-4, Pages 153-160Publisher
KARGER
DOI: 10.1159/000358822
Keywords
Alzheimer's disease; Neuropsychiatric symptoms; Behavioral and psychological symptoms of dementia; Anxiety; Neuroimaging
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Funding
- Ministry of Education, Science, Sports and Culture of Japan
- [23791354]
- Grants-in-Aid for Scientific Research [25893251, 221S0003] Funding Source: KAKEN
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Introduction: Although anxiety symptoms are often observed in Alzheimer's disease (AD), little attention has been paid to this symptom compared with other neuropsychiatric symptoms. Methods: Twenty-six patients with mild AD underwent both magnetic resonance imaging and single photon emission tomography with technetium-99m ethyl cysteinate dimer. Neuropsychiatric symptoms were evaluated using the Behavioral Pathology in Alzheimer's Disease Scale (Behave-AD). We investigated the relationship between anxiety and neuroimaging using Statistical Parametric Mapping 8 software. Results: The Behave-AD anxiety score was correlated with hyperperfusion in the bilateral anterior cingulate cortices and a reduction in the gray matter volume in the right precuneus and inferior parietal lobule. Conclusion: Our results suggest that anxiety in AD could overlap with the neural correlates of anxiety disorders, and that the specific degeneration associated with AD might be associated with anxiety. (C) 2014 S. Karger AG, Basel
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