Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 26, Issue 4, Pages 330-338Publisher
KARGER
DOI: 10.1159/000161058
Keywords
Depression; Dementia; Parkinson's disease dementia; Lewy body dementia; Serotonin 1A receptors; Cortex
Categories
Funding
- Medical Research Council (UK)
- Norwegian Research Council
- Medical Research Council [G0400074, G0502157] Funding Source: researchfish
- MRC [G0400074, G0502157] Funding Source: UKRI
Ask authors/readers for more resources
Background: Serotonin 1A receptors (5-HT1A) have not been studied in dementia with Lewy bodies (DLB) or Parkinson's disease dementia (PDD) patients with depression. Aim: To examine 5-HT1A in DLB and PDD postmortem in relation to depression. Methods: [H-3]8-hydroxy-2-dipropylaminotetralin binding to 5-HT1A was determined in temporal cortex (Brodmann areas, BA20 and BA36) from 10 DLB patients, 17 PDD patients and 9 controls. Results: 5-HT1A density was significantly higher in BA36 in combined DLB/PDD patients with depression, but was unaltered in BA20. Conclusion: Higher BA36 5-HT1A density in PDD and DLB patients than in control is dependent on whether the patient had experienced depression during life, not DLB/PDD diagnosis. A 5-HT1A antagonist adjuvant may improve treatment of depression in dementia. Copyright (C) 2008 S. Karger AG, Basel
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available