Journal
JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS
Volume 7, Issue 4-6, Pages 232-242Publisher
KARGER
DOI: 10.1159/000380951
Keywords
MTNR1B; FTO; MC4R; Obesity; Body weight loss; Gene-gene interplay; Gene-diet interaction
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Funding
- Linea Especial (University of Navarra) [LE/97]
- Spanish Ministry of Economy and Competitiveness [AGL2013-45554-R]
- Asociacion de Amigos Universidad de Navarra
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Background/Aims: Investigation of the genetic makeup may facilitate the implementation of more personalized nutritional interventions. The aims were to examine whether the rs10830963 MTNR1B polymorphism affects weight loss in response to a hypocaloric diet and to find potential gene-gene interplays and gene-diet interactions. Methods: 167 subjects enrolled in a personalized nutritional intervention for weight loss (3-6 weeks) were examined for anthropometric measurements, dietary habits and physical activity at baseline and at the first follow-up visit. Three polymorphisms, which have previously been associated with body weight regulation, rs10830963 (MTNR1B), rs9939609 (FTO) and rs17782313 (MC4R), were analyzed using the Luminex (R) 100/200 (TM) System. Results: After adjusting for covariates, females with the rs10830963 CG/GG genotype showed lower weight loss than those with the CC genotype. In the total population, carriers of variant alleles of both FTO and MC4R showed a significant association with MTNR1B and weight loss outcome. Moreover, among women, higher total protein and animal protein intakes were associated with a lower weight loss in G allele carriers of the MTNR1B variant. Conclusions: Our data evidenced that rs10830963 MTNR1B polymorphism could be associated with individual differences in weight loss induced by a hypocaloric diet. This association was influenced by FTO and MC4R loci and modified by baseline protein intake. (C) 2015 S. Karger AG, Basel
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