Pros and cons of bifunctional platinum(iv) antitumor prodrugs: two are (not always) better than one

Metal-based anticancer chemotherapeutic agents

(2014) Nafees Muhammad et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Nanoparticle Encapsulation of Mitaplatin and the Effect Thereof on In Vivo Properties

(2013) Timothy C. Johnstone et al.   ACS Nano

Challenges for Metals in Medicine: How Nanotechnology May Help To Shape the Future

(2013) Nicolas P. E. Barry et al.   ACS Nano

Platinum(IV) Prodrugs with Haloacetato Ligands in the Axial Positions can Undergo Hydrolysis under Biologically Relevant Conditions

(2013) Ezequiel Wexselblatt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeted delivery of platinum-based anticancer complexes

(2013) Jennifer S Butler et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Antiproliferative activity of Pt(IV)-bis(carboxylato) conjugates on malignant pleural mesothelioma cells

(2013) Manuela Alessio et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

αVβ3 Integrin-Targeted PLGA-PEG Nanoparticles for Enhanced Anti-tumor Efficacy of a Pt(IV) Prodrug

(2012) Nora Graf et al.   ACS Nano

Redox activation of metal-based prodrugs as a strategy for drug delivery

(2012) Nora Graf et al.   ADVANCED DRUG DELIVERY REVIEWS

Glutathione Transferases as Targets for Cancer Therapy

(2012) Paolo Ruzza et al.   Anti-Cancer Agents in Medicinal Chemistry

A dual-targeting hybrid platinum(iv) prodrug for enhancing efficacy

(2012) Haihua Xiao et al.   CHEMICAL COMMUNICATIONS

Targeting and delivery of platinum-based anticancer drugs

(2012) Xiaoyong Wang et al.   CHEMICAL SOCIETY REVIEWS

The Synergistic Effects of DNA-Targeted Chemotherapeutics and Histone Deacetylase Inhibitors As Therapeutic Strategies for Cancer Treatment

(2012) M. Stiborova et al.   CURRENT MEDICINAL CHEMISTRY

Dinuclear Pt(ii)-bisphosphonate complexes: a scaffold for multinuclear or different oxidation state platinum drugs

(2012) Sara Piccinonna et al.   DALTON TRANSACTIONS

Synthesis, characterization and antiproliferative activity on mesothelioma cell lines of bis(carboxylato)platinum(iv) complexes based on picoplatin

(2012) Mauro Ravera et al.   DALTON TRANSACTIONS

Antiproliferative Activity of PtII Complexes with Carboxylated Phosphanes in Chelated or Ring-Opened Forms

(2012) Mauro Ravera et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Metallo-drugs in the treatment of malignant pleural mesothelioma

(2012) Ilaria Zanellato et al.   INORGANICA CHIMICA ACTA

Silica xerogels and hydroxyapatite nanocrystals for the local delivery of platinum–bisphosphonate complexes in the treatment of bone tumors: A mini-review

(2012) Michele Iafisco et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

What do we know about the reduction of Pt(IV) pro-drugs?

(2012) Ezequiel Wexselblatt et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Mitaplatin Increases Sensitivity of Tumor Cells to Cisplatin by Inducing Mitochondrial Dysfunction

(2012) Xue Xue et al.   MOLECULAR PHARMACEUTICS

Conjugate of Pt(IV)–Histone Deacetylase Inhibitor as a Prodrug for Cancer Chemotherapy

(2012) Jun Yang et al.   MOLECULAR PHARMACEUTICS

Multifunctional Pt(iv) pro-drug and its micellar platform: to kill two birds with one stone

(2012) Haiqin Song et al.   Journal of Materials Chemistry B

Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation

(2011) Lorien J. Parker et al.   CHEMISTRY-A EUROPEAN JOURNAL

Evaluation of Platinum-Ethacrynic Acid Conjugates in the Treatment of Mesothelioma

(2011) Ilaria Zanellato et al.   ChemMedChem

Clinical and pharmacokinetic evaluation of satraplatin

(2011) Gury Doshi et al.   Expert Opinion on Drug Metabolism & Toxicology

Synthesis, Characterization, and Cytotoxic Activity of Novel Potentially pH-Sensitive Nonclassical Platinum(II) Complexes Featuring 1,3-Dihydroxyacetone Oxime Ligands

(2011) Yulia Yu. Scaffidi-Domianello et al.   INORGANIC CHEMISTRY

Nanoparticledrug delivery enhances the cytotoxicity of hydrophobic–hydrophilic drug conjugates

(2011) Santosh Aryal et al.   JOURNAL OF MATERIALS CHEMISTRY

Nanocrystalline carbonate-apatites: role of Ca/P ratio on the upload and release of anticancer platinum bisphosphonates

(2011) Michele Iafisco et al.   Nanoscale

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

(2010) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Mitochondrial Energetics and Therapeutics

(2010) Douglas C. Wallace et al.   Annual Review of Pathology-Mechanisms of Disease

Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects

(2010) Hiroshi Maeda   BIOCONJUGATE CHEMISTRY

Advances in Platinum Chemotherapeutics

(2010) Benjamin W. Harper et al.   CHEMISTRY-A EUROPEAN JOURNAL

The status of platinum anticancer drugs in the clinic and in clinical trials

(2010) Nial J. Wheate et al.   DALTON TRANSACTIONS

Tuning of lipophilicity and cytotoxic potency by structural variation of anticancer platinum(IV) complexes

(2010) Michael R. Reithofer et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Platinum–bisphosphonate complexes have proven to be inactive chemotherapeutics targeted for malignant mesothelioma because of inappropriate hydrolysis

(2010) Nicola Margiotta et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The Drug Targeting and Delivery Approach Applied to Pt-Antitumour Complexes. A Coordination Point of View

(2009) E. Gabano et al.   CURRENT MEDICINAL CHEMISTRY

Satraplatin: leading the new generation of oral platinum agents

(2009) Ashish Bhargava et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Multinational, Double-Blind, Phase III Study of Prednisone and Either Satraplatin or Placebo in Patients With Castrate-Refractory Prostate Cancer Progressing After Prior Chemotherapy: The SPARC Trial

(2009) Cora N. Sternberg et al.   JOURNAL OF CLINICAL ONCOLOGY

Smart delivery of antitumoral platinum complexes from biomimetic hydroxyapatite nanocrystals

(2009) Michele Iafisco et al.   JOURNAL OF MATERIALS CHEMISTRY

Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate

(2009) Shanta Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

(2008) E D Michelakis et al.   BRITISH JOURNAL OF CANCER