4.7 Article

Mitochondria-targeting phosphorescent iridium(III) complexes for living cell imaging

Journal

DALTON TRANSACTIONS
Volume 43, Issue 44, Pages 16872-16879

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4dt00823e

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Funding

  1. Natural Science Foundation of China [21005084, 21072218]

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Two phosphorescent iridium(III) complexes conjugated to a lipophilic triphenylphosphonium cation moiety, IrMitoOlivine and IrMitoNIR, were synthesized. The complexes show high mitochondria-specificity and relatively lower cytotoxicity. Time-lapse confocal imaging indicates that both complexes exhibit an excellent anti-photobleaching capability under continuous laser irradiation.

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