Journal
DALTON TRANSACTIONS
Volume 43, Issue 14, Pages 5535-5545Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3dt53095g
Keywords
-
Categories
Funding
- CRUK
- EPSRC
- MRC
- Department of Health [C2536/A10337]
- MRC [MC_U120081322] Funding Source: UKRI
- Cancer Research UK [10337] Funding Source: researchfish
- Medical Research Council [MC_U120081322] Funding Source: researchfish
Ask authors/readers for more resources
A series of new upconversion nanoparticles have been functionalised with tumour-targeting molecules and metal chelates, prepared following standard peptidic and thiol chemistry. The targeting strategy has been delivered via the alpha(v)beta(3) integrin, which is a heterodimeric cell surface receptor that is up-regulated in a variety of cancers, such as melanoma and breast cancer. The well-known DOTA (1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid) motif allows coordination to the radionuclide Ga-68. Radiolabelling experiments were optimised under relatively mild conditions, and are rare amongst nanoparticulate materials. In vivo application of these probes in mouse tumour models revealed their potential as specific cancer contrast agents for PET imaging.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available