Multifunctional iron-chelators with protective roles against neurodegenerative diseases

Design, synthesis and pharmacological evaluation of novel tacrine–caffeic acid hybrids as multi-targeted compounds against Alzheimer’s disease

(2012) Xiaojuan Chao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The rich electrochemistry and redox reactions of the copper sites in the cellular prion protein

(2012) Feimeng Zhou et al.   COORDINATION CHEMISTRY REVIEWS

The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases

(2012) Cristina Rodríguez-Rodríguez et al.   COORDINATION CHEMISTRY REVIEWS

Copper, zinc and iron in neurodegenerative diseases (Alzheimer's, Parkinson's and prion diseases)

(2012) Henryk Kozlowski et al.   COORDINATION CHEMISTRY REVIEWS

Hydroxy(thio)pyrone and hydroxy(thio)pyridinone iron chelators: Physico-chemical properties and anti-oxidant activity

(2012) Sílvia Chaves et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Multitarget-Directed Benzylideneindanone Derivatives: Anti-β-Amyloid (Aβ) Aggregation, Antioxidant, Metal Chelation, and Monoamine Oxidase B (MAO-B) Inhibition Properties against Alzheimer’s Disease

(2012) Ling Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42 Peptide

(2012) Anuj K. Sharma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydroxypyridinones as “privileged” chelating structures for the design of medicinal drugs

(2011) M. Amélia Santos et al.   COORDINATION CHEMISTRY REVIEWS

Metal attenuating therapies in neurodegenerative disease

(2011) Alexandra I Mot et al.   Expert Review of Neurotherapeutics

Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase

(2010) Ling Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation

(2010) Wen Luo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors

(2010) Jaroslav Šebestík et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Treatment of Alzheimer’s Disease with a Cholinesterase Inhibitor Combined with Antioxidants

(2010) Umberto Cornelli   Neurodegenerative Diseases

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution

(2010) Harry Levine   PROTEIN SCIENCE

N-Aryl-substituted 3-(β-D-glucopyranosyloxy)-2-methyl-4(1H)-pyridinones as agents for Alzheimer's therapy

(2010) Lauren E. Scott et al.   Chemical Science

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A facile method for expression and purification of the Alzheimer’s disease-associated amyloid β-peptide

(2009) Dominic M. Walsh et al.   FEBS Journal

Synthesis and Evaluation of Three18F-Labeled Aminophenylbenzothiazoles as Amyloid Imaging Agents

(2009) Kim Serdons et al.   JOURNAL OF MEDICINAL CHEMISTRY

Site-Activated Multifunctional Chelator with Acetylcholinesterase and Neuroprotective−Neurorestorative Moieties for Alzheimer’s Therapy

(2009) Hailin Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Complexes of hydroxy(thio)pyrone and hydroxy(thio)pyridinone with Zn(ii) and Mo(vi). Thermodynamic stability and insulin-mimetic activity

(2009) Sílvia Chaves et al.   Metallomics

Pharmacotherapeutic targets in Alzheimer's disease

(2008) Yif'at Biran et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuroscience: The plaque plan

(2008) Alison Abbott   NATURE

Therapeutics for Alzheimer’s disease based on the metal hypothesis

(2008) Ashley I. Bush et al.   Neurotherapeutics

The Fenton Activity of Iron(III) in the Presence of Deferiprone

(2007) Lakshmi D. Devanur et al.   JOURNAL OF PHARMACEUTICAL SCIENCES