Catalytic mechanism of cytochrome P450 for N-methylhydroxylation of nicotine: reaction pathways and regioselectivity of the enzymatic nicotine oxidation

Why Does the G117H Mutation Considerably Improve the Activity of Human Butyrylcholinesterase against Sarin? Insights from Quantum Mechanical/Molecular Mechanical Free Energy Calculations

(2012) Yuan Yao et al.   BIOCHEMISTRY

Reaction Pathway and Free Energy Profiles for Butyrylcholinesterase-Catalyzed Hydrolysis of Acetylthiocholine

(2012) Xi Chen et al.   BIOCHEMISTRY

Reaction Pathway and Free Energy Profile for Cocaine Hydrolase-Catalyzed Hydrolysis of (−)-Cocaine

(2012) Junjun Liu et al.   Journal of Chemical Theory and Computation

Cytochrome P450-Catalyzed Degradation of Nicotine: Fundamental Parameters Determining Hydroxylation by Cytochrome P450 2A6 at the 5′-Carbon or the N-Methyl Carbon

(2012) Renata A. Kwiecień et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Fundamental Reaction Pathway and Free Energy Profile for Inhibition of Proteasome by Epoxomicin

(2012) Donghui Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fundamental Reaction Pathway and Free Energy Profile for Hydrolysis of Intracellular Second Messenger Adenosine 3′,5′-Cyclic Monophosphate (cAMP) Catalyzed by Phosphodiesterase-4

(2011) Xi Chen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Reaction Mechanism for Cocaine Esterase-Catalyzed Hydrolyses of (+)- and (−)-Cocaine: Unexpected Common Rate-Determining Step

(2011) Junjun Liu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Catalytic Mechanism of Cytochrome P450 for 5′-Hydroxylation of Nicotine: Fundamental Reaction Pathways and Stereoselectivity

(2011) Dongmei Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fundamental Reaction Pathways for Cytochrome P450-Catalyzed 5′-Hydroxylation andN-Demethylation of Nicotine

(2010) Dongmei Li et al.   JOURNAL OF PHYSICAL CHEMISTRY B

An Acyl Group Makes a Difference in the Reactivity Patterns of Cytochrome P450 CatalyzedN-Demethylation of SubstitutedN,N-Dimethylbenzamides—High Spin Selective Reactions

(2010) Yong Wang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Reaction Pathway and Free Energy Profile for Butyrylcholinesterase-Catalyzed Hydrolysis of Acetylcholine

(2010) Xi Chen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Fundamental Reaction Mechanism and Free Energy Profile for (−)-Cocaine Hydrolysis Catalyzed by Cocaine Esterase

(2009) Junjun Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Theoretical study of N-dealkylation of N-cyclopropyl-N-methylaniline catalyzed by cytochrome P450: insight into the origin of the regioselectivity

(2008) Dongmei Li et al.   DALTON TRANSACTIONS

Multimodal techniques for smoking cessation: a review of their efficacy and utilisation and clinical practice guidelines

(2008) V. I. Reus et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Most Efficient Cocaine Hydrolase Designed by Virtual Screening of Transition States

(2008) Fang Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY