Article
Environmental Sciences
Hanaa S. S. Gazwi, Osama I. A. Soltan, Sanaa M. Abdel-Hameed
Summary: The study aimed to investigate the immunostimulant effects of papaya seed-enriched cakes in countering carbon tetrachloride-induced immunocytotoxicity in rats. The results showed that the consumption of these cakes can mitigate the harmful effects on the blood, liver, and immune system caused by carbon tetrachloride, with antioxidant and liver-protective properties.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Min Li, Yidi Kong, Wanqing Guo, Xueqin Wu, Jiawen Zhang, Yingqian Lai, Yuxin Kong, Xiaotian Niu, Guiqin Wang
Summary: This study found that dietary aflatoxin B-1 reduces the growth performance and humoral immunity of northern snakehead, while inducing oxidative stress, endoplasmic reticulum stress, apoptosis, and inflammation in the liver.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Estefania Bravo-Sanchez, Donovan Pena-Montes, Sarai Sanchez-Duarte, Alfredo Saavedra-Molina, Elizabeth Sanchez-Duarte, Rocio Montoya-Perez
Summary: The study showed that treatment with apocynin significantly improved blood glucose levels and insulin resistance in diabetic rats, attenuated oxidative stress responses, enhanced mitochondrial function and antioxidant defense. Apocynin has a protective effect against diabetic complications.
Article
Environmental Sciences
Ezgi Nur Demirkapi, Sinan Ince, Hasan Huseyin Demirel, Damla Arslan-Acaroz, Ulas Acaroz
Summary: This study demonstrates the protective effect of polydatin (PD) against oxidative stress caused by aflatoxin B-1 (AFB(1)) in mice. PD administration at increasing doses effectively reduced oxidative stress, DNA damage, and inflammation induced by AFB(1). Furthermore, PD improved liver and kidney tissue damage caused by AFB(1). These findings highlight the potential of PD as a therapeutic agent against AFB(1)-induced toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Wanyue Huang, Zheng Cao, Yilong Cui, Siming Huo, Bing Shao, Miao Song, Ping Cheng, Yanfei Li
Summary: Lycopene (LYC) has protective effects against AFB1-induced testicular lesion by attenuating oxidative stress and mitochondrial damage, which is related to the activation of Nrf2 signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Food Science & Technology
Huimin Ma, Qi Chen, Haiming Yang, Xiaoli Wan
Summary: This study found that LYC can alleviate the negative impacts of AFB(1) on the growth performance, meat quality, and antioxidant capacity of broilers' breast muscle.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Food Science & Technology
Qi Wang, Fubo Jia, Chen Guo, Yuping Wang, Xuliang Zhang, Yilong Cui, Miao Song, Zheng Cao, Yanfei Li
Summary: The study found that PINK1/Parkin-mediated mitophagy plays an important role in attenuating AFB(1)-induced liver injury.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Food Science & Technology
Mariana Leitao, Tatiana Ribeiro, Pablo A. Garcia, Luisa Barreiros, Patricia Correia
Summary: Fermented papaya has proven to be an excellent antioxidant and nutraceutical adjuvant, with positive impacts on the treatment of various diseases.
Article
Environmental Sciences
Rui Sang, Bingjie Ge, Haifeng Li, Hongyuan Zhou, Kexin Yan, Wei Wang, Qichao Cui, Xuemei Zhang
Summary: This study aimed to investigate the intervention effect and mechanism of taraxasterol on liver damage induced by AFB1 in broiler chickens. The results showed that taraxasterol alleviated liver damage through regulation of Keap1/Nrf2 signaling pathway, improved anti-apoptotic ability, and restored autophagy.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Microbiology
Jiahui Yan, Lin Chen, Li Zhang, Zhaohuan Zhang, Yong Zhao, Yuan Wang, Jie Ou
Summary: This study investigates the persistent effects of acute exposure to aflatoxin B-1 (AFB1) on the liver of rats. The results demonstrate that AFB1 causes irreversible liver damage at both phenotypic and genetic levels. Certain genes (such as Lama5, Gtse1, Fabp4, and Bcl6) show potential as therapeutic targets for AFB1-induced liver disease.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Sukhchain Kaur, Rubal, Satveer Kaur, Amandeep Kaur, Sandeep Kaur, Sushil Gupta, Sunil Mittal, Monisha Dhiman
Summary: The present study aims to understand the complex interaction between oxidative stress, inflammation and antioxidant system in hypertension. It is observed that metabolic markers are altered in hypertensive subjects, showing increased oxidative and inflammatory profiles and compromised antioxidant status compared to normotensive subjects. Correlation analysis validates the involvement of inflammation and oxidative stress in impaired endothelial function and vital organ damage.
Article
Chemistry, Applied
Anatoly Petrovich Karmanov, Albert Vladimirovich Kanarsky, Lyudmila Sergeevna Kocheva, Eduard Ilyasovich Semenov, Vladimir Aleksandrovich Belyy
Summary: The study found that lignins have good adsorption properties and antioxidant capabilities, with lignins from Jerusalem artichoke and ledum showing the highest adsorption performance.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Shahid Ali Rajput, Aftab Shaukat, Kuntan Wu, Imran Rashid Rajput, Dost Muhammad Baloch, Rana Waseem Akhtar, Muhammad Asif Raza, Agnieszka Najda, Paplinski Rafal, Ashraf Albrakati, Attalla F. El-Kott, Mohamed M. Abdel-Daim
Summary: Luteolin significantly alleviated liver injury induced by Aflatoxin B-1, potentially through the activation of the Nrf2 signaling pathway.
Article
Food Science & Technology
Davide Di Paola, Carmelo Iaria, Fabiano Capparucci, Marika Cordaro, Rosalia Crupi, Rosalba Siracusa, Ramona D'Amico, Roberta Fusco, Daniela Impellizzeri, Salvatore Cuzzocrea, Nunziacarla Spano, Enrico Gugliandolo, Alessio Filippo Peritore
Summary: This study confirmed the effects of AFB1 on zebrafish embryos and larvae, evaluated oxidative stress pathways, and the protective effect of Hericium extract. Results suggest that Hericium may counteract AFB1 toxicity mechanisms by promoting antioxidant defense systems and reducing lipid peroxidation in fish development.
Article
Medicine, Research & Experimental
Shogo Imanaka, Yuki Yamada, Naoki Kawahara, Hiroshi Kobayashi
Summary: This study investigated the redox balance in endometriosis by measuring iron-related compounds and antioxidants in cyst fluid samples. The results showed higher levels of iron-related compounds and antioxidants in endometriosis patients compared to those without endometriosis. Furthermore, it was found that HO-1 may regulate iron-induced oxidative stress in endometriotic cyst fluid.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Food Science & Technology
Usman Pato, Emma Riftyan, Dewi Fortuna Ayu, Nia Naidya Jonnaidi, Mimi Sri Wahyuni, Jeska Aryaningsih Feruni, Mosaad Attia Abdel-Wahhab
Summary: This study evaluated the characteristics of bacteriocin from dadih's LAB and found that it has the ability to inhibit the growth of Staphylococcus aureus. Several LAB strains showed antimicrobial activity through the action of organic acids or bacteriocin. Bacteriocin strain R-55 exhibited the strongest inhibitory effect against S. aureus.
FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Environmental Sciences
Hanan M. Rashwan, Hagar E. Mohammed, Aziza A. El-Nekeety, Zeinab K. Hamza, Sekena H. Abdel-Aziem, Nabila S. Hassan, Mosaad A. Abdel-Wahhab
Summary: This study showed that Salvia officinalis has a protective effect against oxidative damage and genotoxicity induced by cadmium in rats, by alleviating disturbances in liver and kidney indices. Its bioactive compounds serve as potential antioxidants, protecting the body from environmental toxins.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Mosaad A. Abdel-Wahhab, Aziza A. El-Nekeety, Hagar E. Mohammed, Ola I. Elshafey, Sekena H. Abdel-Aziem, Nabila S. Hassan
Summary: This study synthesized and characterized TiO2-NPs and ETEO, analyzed the chemical components of ETEO, and evaluated their protective role against TiO2-NPs-induced damage in rats. The results demonstrated that ETEO improved parameters such as oxidative stress and genotoxicity induced by TiO2-NPs in a dose-dependent manner.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Immunology
Manal A. Abdel-Aziz, Helmy M. S. Ahmed, Aziza A. El-Nekeety, Hafiza A. Sharaf, Sekena H. Abdel-Aziem, Mosaad A. Abdel-Wahhab
Summary: This study demonstrated the therapeutic effects of gold nanoparticles and Diacerein in experimental osteoarthritis, with gold nanoparticles showing greater efficacy compared to Diacerein and the combination treatment having the most significant impact.
INFLAMMOPHARMACOLOGY
(2021)
Article
Plant Sciences
Hossein Abbaspour, Fatemeh S. N. Pour, Mosaad A. Abdel-Wahhab
Summary: The study demonstrates that using arbuscular mycorrhizal fungus can alleviate the negative effects of salinity stress on pistachio plants, promoting plant growth and nutrient uptake, maintaining ion balance, and protecting cell membrane integrity.
PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS
(2021)
Article
Environmental Sciences
Mona A. El-Banna, Omnia M. Hendawy, Aziza A. El-Nekeety, Mosaad A. Abdel-Wahhab
Summary: Solid tumors are difficult to surgically remove and often do not respond to radiation and chemotherapy. This study fabricated ginsenoside Rg3 nanoparticles and evaluated their antitumor effect in mice. The results showed that Rg3-NPs were more effective than regular Rg3 in reducing tumor weight and size, and the effect was dose-dependent. The fabrication of Rg3-NPs enhanced the protective effect against tumor development.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mohamed F. Sallam, Helmy M. S. Ahmed, Aziza A. El-Nekeety, Kawthar A. Diab, Sekena H. Abdel-Aziem, Hafiza A. Sharaf, Mosaad A. Abdel-Wahhab
Summary: This study evaluates the oxidative damage, genotoxicity, and DNA damage in the liver of rats treated with titanium nanoparticles (TiO2-NPs) and examines the protective role of holy basil essential oil nanoemulsion (HBEON). The results suggest that co-administration of TiO2-NPs plus HBEON improves all tested parameters and liver histology, with HBEON being more effective. This study highlights the potential of HBEON in protecting against oxidative damage and DNA damage caused by TiO2-NPs exposure.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Sara Gheraibia, Noureddine Belattar, Kawthar A. Diab, Marwa E. Hassan, Aziza A. El-Nekeety, Sekena H. Abdel-Aziem, Nabila S. Hassan, Mosaad A. Abdel-Wahhab
Summary: This study investigated the protective effects of Costus speciosus extract (CSE) against Zearalenone (ZEN)-induced oxidative damage, genotoxicity, and cytotoxicity. The results showed that CSE could alleviate ZEN toxicity through its antioxidant activity, modulation of iNOS, inflammatory related genes, and the Nrf2 pathway.
Correction
Environmental Sciences
Asmaa S. Salman, Turki M. Al-Shaikh, Zeinab K. Hamza, Aziza A. El-Nekeety, Salwa S. Bawazir, Nabila S. Hassan, Mosaad A. Abdel-Wahhab
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Materials Science, Biomaterials
Rasha Y. Abdel-Ghafar, Amira E. Sehim, Zeinab K. Hamza, Aziza A. El-Nekeety, Mosaad A. Abdel-Wahhab
Summary: This study successfully synthesized and characterized vanadium nanoparticles (VNPs) using orange peel extract, and evaluated their antimicrobial, antioxidant, and anticancer activities. The biosynthesized VNPs showed strong antifungal and antibacterial activities, as well as potent antioxidant and anticancer activities.
Article
Pharmacology & Pharmacy
Alaa Abd El-Gawad, Mohamed A. Kenawy, Tamer M. El-Messery, Marwa E. Hassan, Aziza A. El-Nekeety, Mosaad A. Abdel-Wahhab
Summary: Despite advancements in cancer therapy, it remains the leading cause of global death. Bee venom (BV) has exhibited cytotoxic effects against malignant cells, but its application in humans is limited due to allergic reactions and other toxicities. This study aimed to develop BV-loaded nanoliposomes (BV@NLs) and evaluate their anticancer activity against different cancer cell lines.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Environmental Sciences
Hanaa M. M. Soliman, Mosaad A. A. Abdel-Wahhab
Summary: This study aimed to develop biological compounds using linoleic acid extracted from melon seed oil, and to treat fried oils using melon seed cake ash. Eight active compounds were developed and their structures were determined. These compounds showed antibacterial activity. Melon seed oil was rich in linoleic acid (61.4%) and other fatty acids. Linoleic acid had high refractive index, iodine value, saponification, while having low peroxide value, polymer content, polar contents, and moisture content. Melon seed ash contained various metals and improved the physicochemical properties of fried oils. Linoleic acid was used to develop 9 compounds with antimicrobial activity, and melon seed ash improved the chemical characteristics of used cotton and sunflower oils.
WASTE AND BIOMASS VALORIZATION
(2023)
Article
Biochemistry & Molecular Biology
Aziza A. El-Nekeety, Mona A. Hassan, Sekena H. Abdel-Aziem, Nabila S. Hassan, Mosaad A. Abdel-Wahhab
Summary: This study aimed to synthesize whey protein nanoparticles (WPNPs) for the coating of zinc citrate (Zn CITR) and investigate their protective role against CCl4-induced kidney damage and inflammatory gene expression disorder in rats. The results showed that WPNPs and Zn CITR-WPNPs had a protective effect against these complications, with Zn CITR-WPNPs (LD) being the most effective.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Food Science & Technology
Usman Pato, Emma Riftyan, Nia N. Jonnaidi, Mimi S. Wahyuni, Jeska A. Feruni, Mosaad A. Abdel-Wahhab
Summary: This study evaluated the antimicrobial efficiency and stability of bacteriocins produced by dadih's LAB against Erwinia carotovora under different pH, temperature, and enzymatic treatments. The results demonstrated that certain bacteriocins showed high stability under various pH and temperature conditions.
FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fathia Abd Elwahid Mannaa, Khaled Gamal El-Deen Abdel-Wahhab, Eitedal Mahmoud Daoud, Aliaa Abdel Rahman El Gendy, Maha Mohamed Saber, Nevein Naim Fadl
Summary: The study aimed to evaluate the efficacy of low-power laser therapy (LPLT) in managing peripheral neuropathy induced by xenobiotics in a rats' model. The results showed that LPLT was more effective than gabapentin in improving pain sensations and memory deterioration. Biochemical analysis revealed that LPLT significantly decreased beta-endorphin levels and normalized inflammatory cytokines levels, while gabapentin did not have the same effects.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2021)
