Article
Medicine, General & Internal
Slawomir Lewicki, Monika Lesniak, Agnieszka Sobolewska-Ruta, Aneta Lewicka, Marta Grodzik, Eugeniusz K. Machaj, Marek Saracyn, Jacek Z. Kubiak, Zygmunt Pojda
Summary: Encapsulation of cytokines in liposomes is an efficient method to deliver cytokines to cells at working concentrations without affecting cell morphology or proliferation. This method has great potential and important applications in tissue regeneration and other fields.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Dermatology
K. Wolk, T. -C. Brembach, D. Simaite, E. Bartnik, S. Cucinotta, A. Pokrywka, M. L. Irmer, J. Triebus, E. Witte-Haendel, G. Salinas, T. Leeuw, H. -D. Volk, K. Ghoreschi, R. Sabat
Summary: The expression of G-CSF is high in HS skin, especially in inflamed nodules and abscesses. IL-1 and IL-17 induce G-CSF production, and G-CSF blood levels correlate with the severity of HS.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Cell Biology
Tuba Mustafa, Irfan Khan, Hana'a Iqbal, Sehrish Usman, Nadia Naeem, Shaheen Faizi, Asmat Salim
Summary: Myocardial infarction (MI) permanently damages cardiomyocytes and impairs cardiac function. Mesenchymal stem cells (MSCs), with their ability to differentiate into multiple lineages, are considered a promising option for MI treatment. However, aging reduces their regenerative capability due to the accumulation of reactive oxygen species (ROS) that ultimately cause cell death. This study aimed to enhance the cardiac regeneration potential of aging rat-derived bone marrow MSCs by treating them with antioxidants, rutin or quercetagetin.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Dermatology
J. Karim Ead, David G. Armstrong
Summary: GM-CSF is a glycoprotein with immunomodulatory properties derived from both hemopoietic and nonhemopoietic sources. In patients with diabetic foot ulcers, GM-CSF activation is impaired, leading to impaired inflammatory response. Correcting macrophage immune dysfunction with exogenous GM-CSF may help restore immune balance and promote wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Shao-Yu Tang, Yi-Chin Lee, Chien-Wei Tseng, Po-Hsun Huang, Ko-Lin Kuo, Der-Cherng Tarng
Summary: This study found that G-CSF can improve angiogenic function in patients with peripheral arterial disease (PAD) associated with chronic kidney disease (CKD) through a hypoxia/IL-10 signaling cascade.
Article
Cell Biology
Alexandra Calle, Miguel Angel Gutierrez-Reinoso, Michela Re, Javier Blanco, Julio De la Fuente, Marta Monguio-Tortajada, Francesc Enric Borras, Maria Yanez-Mo, Miguel Angel Ramirez
Summary: Circulating MSCs are present in peripheral blood under healthy conditions and may participate in the immune tolerance of the mother towards the embryo during early pregnancy. There is a possible active recruitment of MSCs from bone marrow to repress the immune response to prevent the embryo rejection.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Jingjing Wen, Qiaolin Zhou, Lin Shi, Fang Xu, Yiping Liu, Jing Su, Ya Zhang, Wen Qu, Jing Yue
Summary: The study aimed to evaluate the efficacy of mecapegfilgrastim as a mobilization agent for hematopoietic stem cell transplantation in patients with hematologic malignancies and investigate potential factors associated with mobilization failure. The results showed that mecapegfilgrastim had comparable mobilization efficacy to rhG-CSF in patients with hematologic malignancies, and the combination with plerixafor was feasible and effective. Furthermore, patients with more than 5 cycles of chemotherapy, a precollection white blood cell count lower than 32 x 10^9/L, and a precollection lymphocyte count less than 1.7 times the premobilization lymphocyte count had a higher risk of mobilization failure.
Article
Chemistry, Multidisciplinary
Huihui He, Yuan Yuan, Yunhong Wu, Jingyi Lu, Xiaofu Yang, Kejie Lu, An Liu, Zelin Cao, Miao Sun, Mengfei Yu, Huiming Wang
Summary: The integration of metal-organic frameworks exoskeletons with bone marrow stem cells (BMSCs) improves cell survival and enhances cardiac repair. The partially coated cells are able to withstand detrimental environmental conditions and promote cell adhesion. The interaction between exoskeletons and cell surface receptors leads to altered gene expression and enhanced biological functions.
ADVANCED MATERIALS
(2023)
Article
Virology
Sarah Stonedahl, J. Smith Leser, Penny Clarke, Huntington Potter, Timothy D. D. Boyd, Kenneth L. L. Tyler
Summary: West Nile virus (WNV) is the main cause of epidemic arboviral encephalitis in the United States. Depleting microglia in WNV-infected mice enhances viral replication and tissue injury, while augmenting microglial activation through GM-CSF administration reduces viral titers and apoptotic activity and increases survival. Stimulation of microglial activation may be a viable therapeutic approach for WNV neuroinvasive disease.
JOURNAL OF VIROLOGY
(2023)
Article
Oncology
Chong Wei, Yan Zhang, Wei Wang, Wei Zhang
Summary: Substituting PEG-rhG-CSF for short-acting rhG-CSF in the DA-EPOCH regimen significantly reduces the incidence of febrile neutropenia and related hospitalization, while simplifying management for both patients and healthcare providers.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Endocrinology & Metabolism
Guang-Yin Shen, Jeong-Hun Shin, Yi-Sun Song, Hyun-Woo Joo, In-Hwa Park, Jin-Hee Seong, Na-Kyoung Shin, A-Hyeon Lee, Young Jong Cho, Yonggu Lee, Young-Hyo Lim, Hyuck Kim, Kyung-Soo Kim
Summary: The study showed that G-CSF can reduce cardiomyocyte apoptosis in diabetic cardiomyopathy by increasing autophagy levels. The anti-apoptotic effect of G-CSF was found to be abrogated by autophagy inhibitors, indicating the significance of autophagy up-regulation in mediating the protective effects of G-CSF.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Oncology
Xia-Qiu Tian, Xiao-Song Qian, Hong Wang, Yue-Jin Yang
Summary: This study found that adiponectin (APN) can promote the survival of transplanted mesenchymal stem cells (MSCs) after acute myocardial infarction (AMI) by activating the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway. APN treatment improved cardiac function, reduced infarct size, suppressed inflammation, inhibited cardiomyocyte apoptosis, and increased arteriogenesis and angiogenesis in the peri-infarct myocardium. These effects were associated with AMPK phosphorylation and partially reversed by AMPK pathway inhibitors.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Immunology
Lin Li, Jin Yin, Yun Li, Chunyan Wang, Xia Mao, Jia Wei, Yang Cao, Na Wang, Li Lin, Jinhuan Xu, Yicheng Zhang
Summary: This study compared pegylated granulocyte colony-stimulating factor (peg-G-CSF) with non-peg-G-CSF for hematopoietic stem cell mobilization in allogeneic hematopoietic stem cell transplantation. The mobilization with peg-G-CSF resulted in higher numbers of specific cells and a reduced incidence of severe acute graft-versus-host disease after transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
An-ran Xi, Yi-jun Luo, Jin-Tao Guan, Wei-Jie Wang, Zheng-Hao Xu
Summary: This study analyzed the efficacy and safety of granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies in COVID-19 patients. The results showed that GM-CSF antibody treatment can reduce the incidence of invasive mechanical ventilation and have slight but not significant effects on mortality and ventilation improvement. Sensitivity analysis revealed statistically significant results for mortality and ventilation improvement rate when one study was excluded. Furthermore, GM-CSF antibodies did not increase the risks of secondary infection and adverse events.
INFLAMMOPHARMACOLOGY
(2023)
Article
Oncology
Eva-Maria Klein, Sandra Sauer, Sabrina Klein, Diana Tichy, Axel Benner, Uta Bertsch, Juliane Brandt, Christoph Kimmich, Hartmut Goldschmidt, Carsten Muller-Tidow, Karin Jordan, Nicola Giesen
Summary: This study compared antibiotic prophylaxis with G-CSF support as anti-infective strategies in patients with multiple myeloma undergoing HDT/ASCT, showing that G-CSF support is associated with a shorter duration of hospitalization and a lower rate of emerging multidrug resistant bacteria.