Review
Biochemistry & Molecular Biology
Akiyoshi Uemura, Yoko Fukushima
Summary: Rho GTPases, especially RhoJ, play essential roles in regulating cell migration and junctions in vascular endothelial cells, affecting vascular formation and permeability. RhoJ, enriched in angiogenic ECs, induces actin depolymerization by competing with Cdc42 for common effector proteins, thus influencing cytoskeletal rearrangements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Chin-Kuo Lin, Tzu-Hsiung Huang, Cheng-Ta Yang, Chung-Sheng Shi
Summary: The study found that lung-recruited monocytes post-VILI are predominantly Ly6C(+low), and pulmonary VEGF decreases initially but increases significantly on days 7 and 14 after injury. There is a strong positive correlation between VEGF expression and alveolar epithelial cell proliferation, and the restoration of pulmonary VEGF by monocytes may play a crucial role in post-VILI lung repair.
Article
Immunology
Shuling Zhang, Ning Liu, Mingxing Ma, Hai Huang, Mike Handley, Xueli Bai, Fengping Shan
Summary: The study demonstrated that MENK regulates the biological behavior of lung cancer cells by enhancing apoptosis and immunogenicity while promoting NK cell-driven tumor immunity, potentially inhibiting the proliferation of lung cancer cells through the activation of key signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Cell Biology
Yelda Pakize Kina, Ali Khadim, Werner Seeger, Elie El Agha
Summary: Multiple factors converge to coordinate organogenesis, particularly in the context of lung development where airway branching is considered a rate-limiting step. The reciprocal interaction between the vascular network and airway tree plays a critical role in their patterning, branching, and alignment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Jiannan Gong, Zihang Feng, Abigail L. Peterson, Jennifer F. Carr, Xuexin Lu, Haifeng Zhao, Xiangming Ji, You-Yang Zhao, Monique E. De Paepe, Phyllis A. Dennery, Hongwei Yao
Summary: The study showed that hyperoxia can exacerbate abnormal endothelial cell proliferation and dysmorphic vascular growth in neonatal mice through the pentose phosphate pathway (PPP), while inhibition of the PPP can reduce these effects.
Review
Biochemistry & Molecular Biology
Jean-Luc Wautier, Marie-Paule Wautier
Summary: The study of vascular permeability is important for understanding the mechanism that maintains the exchange between blood, tissues, and organs. Recent research has provided a better understanding of vascular cell functions and interactions between blood vessels. The identification of endothelial cell receptors and mediators and their role in homeostasis and disease has shed light on the maintenance of vascular permeability. Additionally, drugs and specific antibodies have been found to reduce the severity and mortality of diseases with enhanced vascular permeability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Xiao-yu Dai, Li-jun Ren, Lang Yan, Ji-qian-zhu Zhang, Yi-fan Dong, Tao-lin Qing, Wen-jing Shi, Jin-feng Li, Fang-yuan Gao, Xiao-fang Zhang, Yi-jun Tian, Yu-ping Zhu, Jiang-bo Zhu, Ji-kuai Chen
Summary: This study demonstrated that MWCNTs can affect endothelial cell activity, disrupt tube formation and cell migration ability, subsequently affecting angiogenesis. Furthermore, the VEGF-Akt-eNOS axis plays a crucial role in MWCNT-induced endothelial cell injury.
Review
Biochemistry & Molecular Biology
Nunzia Caporarello, Giovanni Ligresti
Summary: Lungs have the ability to regenerate in response to injury, but sustained injuries, aging, and genomic instability make them susceptible to disrepair and fibrosis. Pulmonary fibrosis is a major cause of morbidity, and the dysfunction of the pulmonary vasculature contributes to its progression. This review summarizes current findings related to lung vascular repair and provides insights into the development of persistent lung fibrosis.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qun Lv, Zehai Xia, Yihui Huang, Zhaoyang Ruan, Jianjun Wang, Zhangdan Huang
Summary: In this study, it was found that ginsenoside Rg3 can inhibit the migration, invasion, and angiogenesis of lung cancer cells by suppressing the expressions of COX2 and VEGF.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Pharmacology & Pharmacy
Wenjia Tian, Huifeng Hao, Ming Chu, Jingjing Gong, Wenzhe Li, Yuan Fang, Jindong Zhang, Cunzheng Zhang, Yonghui Huang, Fei Pei, Liping Duan
Summary: This study found that berberine can reduce lung metastasis in pancreatic cancer by improving the endothelial barrier and reducing the infiltration of circulating tumor cells. The results showed that berberine effectively inhibits the enzyme activities of TGFBR1, which plays a key role in the protective effect on endothelial barrier disruption by tumor cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chun-Sheng Kuo, Shih-Yun Chen, Jen-Chieh Tsai
Summary: This study demonstrates that the supercritical fluid extract of Magnolia figo can induce apoptosis in A549 lung cancer cells through specific pathways, highlighting the potential of this plant as a source for developing novel drugs for lung cancer treatment.
Article
Multidisciplinary Sciences
Nunzia Caporarello, Jisu Lee, Tho X. Pham, Dakota L. Jones, Jiazhen Guan, Patrick A. Link, Jeffrey A. Meridew, Grace Marden, Takashi Yamashita, Collin A. Osborne, Aditya Bhagwate, Steven K. Huang, Roberto F. Nicosia, Daniel J. Tschumperlin, Maria Trojanowska, Giovanni Ligresti
Summary: Vascular dysfunction plays a significant role in aging and chronic diseases, but its involvement in lung repair and fibrosis remains unclear. In this study, the authors identified the endothelial transcription factor ERG as a mediator of vascular repair, whose function declines in aged lungs, resulting in sustained fibrosis. These findings highlight the importance of understanding the mechanisms underlying vascular dysfunction in lung fibrosis and provide potential targets for therapeutic interventions.
NATURE COMMUNICATIONS
(2022)
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Article
Cell Biology
Lowell T. Edgar, Hyojin Park, Jessica R. Crawshaw, James M. Osborne, Anne Eichmann, Miguel O. Bernabeu
Summary: Angiogenesis involves the phases of spouting and remodelling, and abnormal remodelling can result in vascular malformation. The dysfunction of cell-cell adherens junctions is implicated in vascular disease and arteriovenous malformations (AVMs). Cell polarity mixture and excessive cell-cell cohesion disrupt cell migration and blood flow.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
