Article
Biochemistry & Molecular Biology
Natalie Vallant, Bynvant Sandhu, Karim Hamaoui, Maria Prendecki, Charles Pusey, Vassilios Papalois
Summary: This study compared the paracrine effects of MSC supernatants from different age and genotype sources on macrophages, revealing distinct patterns of inflammatory marker expression. These findings are crucial for preclinical and clinical studies utilizing MSCs for inflammation and allo-response mitigation in transplant patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Carlos-Hugo Escobar-Soto, Rossana Mejia-Romero, Natalia Aguilera, Juan Pablo Alzate-Granados, Claudia Mendoza-Pinto, Pamela Munguia-Realpozo, Socorro Mendez-Martinez, Mario Garcia-Carrasco, Adriana Rojas-Villarraga
Summary: A systematic literature review evaluated the efficacy and safety of human mesenchymal stem cells (hMSCs) in patients with Systemic Sclerosis (SSc). The study found potential for hMSCs in improving symptoms of SSc patients, but further research with better epidemiological designs is needed for confirmation.
AUTOIMMUNITY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Yuchen Zhang, Naijun Dong, Huanle Hong, Jingxuan Qi, Shibo Zhang, Jiao Wang
Summary: Due to the aging population, stroke has become more prevalent, leading to increased socioeconomic burden. Stem cell transplantation, particularly using mesenchymal stem cells (MSCs), has shown promise in treating stroke by attenuating inflammation, promoting therapeutic effects, inducing blood vessel formation, promoting neurogenesis, reducing infarct volume, and replacing damaged cells. This review discusses the mechanisms of MSCs and their secreted extracellular vehicles (EVs) in stroke treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lina N. Zaripova, Angela Midgley, Stephen E. Christmas, Michael W. Beresford, Clare Pain, Eileen M. Baildam, Rachel A. Oldershaw
Summary: Mesenchymal stem cells (MSCs) have potential as immunosuppressants for treating autoimmune and autoinflammatory diseases. They can reduce inflammation and promote tissue regeneration. However, during the inflammatory process, MSCs become impaired and lose their immunomodulatory activity. Despite challenges and risks, MSCs show promise in the treatment of severe diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Chun-Gu Hong, Meng-Lu Chen, Ran Duan, Xin Wang, Zhi-Lin Pang, Li-Te Ge, Ming Lu, Hui Xie, Zheng-Zhao Liu
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease that is currently incurable. Transplantation of olfactory mucosa mesenchymal stem cells (OM-MSCs) can alleviate symptoms of AD, promote amyloid-beta clearance, and improve cognitive learning and locomotive behavior.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mengzhu Lv, Simeng Zhang, Bo Jiang, Sunrun Cao, Yuqing Dong, Liu Cao, Shu Guo
Summary: The study demonstrated that adipose-derived stem cell therapy can delay replicative senescence and shift metabolic homeostasis, ultimately delaying the aging process by promoting mitophagy and improving mitochondrial quality in cells. The research also showed that ADSC therapy can improve aging-related symptoms and phenotypes through mitochondrial quality control, offering significant potential for future applications in aging-related diseases.
Article
Cell Biology
Xiaoyun Wu, Yongxu Mu, Jingyi Yao, Fuhong Lin, Daocheng Wu, Zhijie Ma
Summary: The study revealed that ADSCs from UC patients exhibited defective immunosuppression, indicating their unsuitability for autologous transplantation in treating UC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Runfeng Zhang, Jiang Yu, Ningkun Zhang, Wensong Li, Jisheng Wang, Guocai Cai, Yu Chen, Yong Yang, Zhenhong Liu
Summary: The study aimed to evaluate the efficacy and safety of intracoronary autologous bone marrow mesenchymal stem cell (BM-MSC) transplantation in patients with ST-segment elevation myocardial infarction (STEMI). Results showed that BM-MSC transplantation did not significantly promote the recovery of left ventricular function and myocardial viability after acute myocardial infarction.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Sahng G. Kim
Summary: Despite the recent surge in studies on dental pulp regeneration using tissue engineering strategies, the translation of these findings into therapeutic applications remains a challenge. This scoping review systematically reviewed the efficacy of mesenchymal stem cell transplantation for dental pulp regeneration, showing potential for vascularized pulp-like tissue regeneration and successful regeneration of vital tissue in clinical trials. More high-quality studies are needed to further evaluate the safety and efficacy of stem cell transplantation for dental pulp regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Anna Andrzejewska, Sylwia Dabrowska, Barbara Lukomska, Miroslaw Janowski
Summary: Neurological disorders pose a growing burden as society ages, with stem cell-based regenerative medicine offering a promising approach. Researchers are studying the application of MSCs to various neurological diseases and focusing on the delivery of stem cells to the brain as an essential and understudied challenge.
Article
Medicine, Research & Experimental
Manju Shrestha, Tiep Tien Nguyen, Jooho Park, Jeong Uk Choi, Simmyung Yook, Jee-Heon Jeong
Summary: Mesenchymal stem cells (MSCs) therapy shows great promise in treating immune disorders and facilitating islet transplantation. By delivering immunomodulatory signals, MSCs can inhibit T cell immune responses and improve the success of islet engraftment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Chenghai Li, Hua Zhao, Linna Cheng, Bin Wang
Summary: MSC-based therapeutics are available for a range of diseases, with autologous and allogeneic MSCs having their own advantages and disadvantages in medical practice. The interaction of transplanted MSCs with their microenvironment can be impacted by factors from different donors, potentially leading to uncertainty in safety and efficacy. Donor-controlled clinical practice is suggested to minimize potential harm in MSC-based therapies.
CELL AND BIOSCIENCE
(2021)
Review
Medicine, General & Internal
Reza Kaboodkhani, Davood Mehrabani, Feridoun Karimi-Busheri
Summary: Otorhinolaryngology involves surgeries on various tissues of the head and neck that control functions like hearing, breathing, and balance. Regenerative medicine offers a new approach by using cell transplantation to promote healing and replacement of damaged tissues. Mesenchymal stem cells have great potential in treating craniofacial defects and diseases in otorhinolaryngology, with their wide range of healing functions and low risk of rejection.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Xuan Tian, Longlong Wu, Xiang Li, Weiping Zheng, Huaiwen Zuo, Hongli Song
Summary: Exosomes derived from heme oxygenase 1-modified bone marrow mesenchymal stem cells (HExos) can attenuate ferroptosis and protect biliary tracts from ischemia reperfusion injury (IRI) in a rat fatty liver transplantation model. HExos deliver miR-204-5p to negatively regulate ferroptosis and protect steatotic grafts, indicating their potential as a strategy to prevent biliary IRI.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Cell Biology
Shengnan Yang, Peipei Liu, Yale Jiang, Zai Wang, Huaping Dai, Chen Wang
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with unknown causes, and currently the only medications that can slow down the progression of the disease and improve survival rate are pirfenidone and nintedanib. The use of mesenchymal stem cells (MSCs) provides a new hope for treating interstitial lung disease, but optimal treatment protocols are still lacking.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Zizhan Huang, Zi Yin, Jialu Xu, Yang Fei, Boon Chin Heng, Xuesheng Jiang, Weishan Chen, Weiliang Shen
Summary: Tendon harbors a specific cell population called tendon stem/progenitor cells (TSPCs) with stem cell characteristics. Advanced single-cell analysis has facilitated the identification and characterization of different subpopulations of TSPCs, shedding light on their roles in tendon biology. Understanding the mechanisms regulated by TSPCs, especially specific subpopulations, can greatly benefit the treatment of tendon diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Yuanhao Xie, Chenqi Tang, Zizhan Huang, Sicheng Zhou, Yuwei Yang, Zi Yin, Boon Chin Heng, Weishan Chen, Xiao Chen, Weiliang Shen
Summary: In vitro extracellular matrix (ECM) remodeling is critical for maintaining stem cell (SC) function. This review summarizes how cells remodel ECM and the significance of ECM remodeling in ex vivo SC culture, as well as outlines the shortcomings of current research and future directions.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
Article
Engineering, Biomedical
Li Wang, Xiaolei Guo, Jiaqing Chen, Zhen Zhen, Bin Cao, Wenqian Wan, Yuandong Dou, Haobo Pan, Feng Xu, Zepu Zhang, Jianmei Wang, Daisong Li, Quanyi Guo, Qing Jiang, Yanan Du, Jiakuo Yu, Boon Chin Heng, Qianqian Han, Zigang Ge
Summary: With the interdisciplinary convergence of biology, medicine, and materials science, there is a growing need to bridge the gap between applied basic research and translational products in the field of biomaterials. This article critically examines the developmental pipeline of biodegradable biomaterials and proposes ideas to integrate different mindsets to guide research and translation, reducing unnecessary research efforts and funding.
BIOACTIVE MATERIALS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Mei Zhuang, Wuwen Zhang, Nuo Cheng, Ling Zhou, Dan Liu, Hua Yan, Ge Fang, Boon Chin Heng, Yan Sun, Guoqing Tong
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Engineering, Biomedical
Ting Zou, Shan Jiang, Baicheng Yi, Qixin Chen, Boon Chin Heng, Chengfei Zhang
Summary: The study demonstrated that SCAPs induced in BDNF-GelMA with small molecule cocktail showed significant upregulation of neural markers, exhibiting morphological characteristics similar to neuronal cells, which may provide a therapeutic platform for neurological disorders.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Cell Biology
Jiabei Yang, Xuewei Zhang, Jiaqing Chen, Boon Chin Heng, Yangzi Jiang, Xiaoyu Hu, Zigang Ge
Summary: The study highlights the important role of macrophages in cartilage regeneration, showing that they promote regeneration by modulating proliferation and apoptosis. Exogeneous macrophages have therapeutic potential in promoting cartilage regeneration by regulating stem cells. Only M2c macrophages are able to promote regeneration of both cartilage tissues and subchondral bone.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biology
Kejia Li, Litong Fan, Jianjing Lin, Boon Chin Heng, Zhantao Deng, Qiujian Zheng, Jue Zhang, Yangzi Jiang, Zigang Ge
Summary: Mesenchymal stem cells (MSCs) can benefit from enhanced chondrogenesis through the combination of nanosecond pulsed electric fields and ghrelin. The sequential order of applying these two stimuli is crucial for promoting cartilage regeneration. This study provides new insights and strategies for future cell-based therapies.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Materials Science, Biomaterials
Xiaohan Dai, Yunyang Bai, Boon Chin Heng, Yiping Li, Zhangui Tang, Changjian Lin, Ousheng Liu, Ying He, Xuehui Zhang, Xuliang Deng
Summary: This study designed biomimetic micro/sub-micro hierarchical surfaces on titanium implants to mitigate inflammatory reactions and osteoclastogenesis, enhance osteogenic differentiation, and promote early osseointegration. The biomimetic hierarchical surfaces inhibited M1 macrophage-mediated inflammatory reactions and decreased osteoclast formation. In vivo, the implants with hierarchical surfaces underwent rapid and early osseointegration. This study offers a novel biomimetic strategy for implant-bone osseointegration in osteoporotic patients.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Cell Biology
Peiwen He, Dengfeng Ruan, Zizhan Huang, Canlong Wang, Yiwen Xu, Honglu Cai, Hengzhi Liu, Yang Fei, Boon Chin Heng, Weishan Chen, Weiliang Shen
Summary: This review discusses the processes of tendon development and repair, involving various regulatory factors and signaling pathways. By studying and comparing these processes, it can provide guidance for the treatment of tendon injuries.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Biomedical
Yaru Guo, Feng Mei, Ying Huang, Siqin Ma, Yan Wei, Xuehui Zhang, Mingming Xu, Ying He, Boon Chin Heng, Lili Chen, Xuliang Deng
Summary: This study demonstrates that matrix stiffness promotes sprouting of endothelial cells and regulates the formation of tip cells through a specific signaling axis. The findings have significant implications for biomaterial design and treatment of pathological conditions.
BIOACTIVE MATERIALS
(2022)
Review
Endocrinology & Metabolism
Jaydeep Roy, Kan Yin Wong, Luca Aquili, Md. Sahab Uddin, Boon Chin Heng, George Lim Tipoe, Kah Hui Wong, Man Lung Fung, Lee Wei Lim
Summary: In this review, the developmental trends and neuroprotective mechanisms of melatonin therapies for Alzheimer's disease (AD) are examined. Melatonin has been shown to alleviate various pathological processes in AD and beneficially affect behavior in animal models. Clinical studies demonstrate positive effects of melatonin on sleep, cognition, behavior, and psychiatric symptoms in AD patients.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Chemistry, Physical
Ruyuan Ding, Yajun Liu, Dawei Cheng, Gang Yang, Wenjing Wu, Haoran Du, Xin Jin, Yihan Chen, Yuanyin Wang, Boon Chin Heng, Qing Yang, Jianguang Xu
Summary: The incorporation of pro-osteogenic growth factors into bone graft materials to enhance bone regeneration is a key research area. The combination of gene therapy and tissue engineering through gene-activated matrix (GAM) provides a solution to overcome the limitations of growth factors degradation. In this study, a novel GAM system with superior bone regeneration capacity was prepared, and in vitro experiments demonstrated excellent biocompatibility and sustained release of therapeutic genes.
Review
Dentistry, Oral Surgery & Medicine
Boon Chin Heng, Yunyang Bai, Xiaochan Li, Xuehui Zhang, Xuliang Deng
Summary: Dental and oral-derived stem cells have high potential for neurogenesis. Using electroactive or electroconductive tissue engineering scaffolds may enhance their neurogenesis. However, there is limited research on these cells, with most scientific information coming from studies on other mesenchymal stem cell lineages.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Engineering, Biomedical
Fangyuan Bao, Junzhi Yi, Yixiao Liu, Yuliang Zhong, Hui Zhang, Zhonglin Wu, Boon Chin Heng, Ying Wang, Ziyang Wang, Lizi Xiao, Hua Liu, Hongwei Ouyang, Jing Zhou
Summary: This study investigates the optimal applied form and underlying mechanisms of nano-hydroxyapatite (nHAP) in bone repair. The results suggest that when nHAP is applied in the fixed state in a 3D form, it can induce optimal osteogenesis and increased bone volume through upregulation of the PI3K-AKT signaling pathway and ITGA7-mediated mechanisms, contrary to the results observed with free nHAP.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Xiaochan Li, Boon Chin Heng, Yunyang Bai, Qianqian Wang, Min Gao, Ying He, Xinwen Zhang, Xuliang Deng, Xuehui Zhang
Summary: The study confirms the dose-response effect of surface electrical charge on SHED neural differentiation and provides insights into the underlying molecular mechanisms and signaling pathways involved.
BIOACTIVE MATERIALS
(2023)