Journal
CYTOTECHNOLOGY
Volume 58, Issue 2, Pages 63-67Publisher
SPRINGER
DOI: 10.1007/s10616-008-9175-7
Keywords
A549 cells; Carrageenan; Detachment; Granzyme A; Interleukin-8 release
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Funding
- Ministry of Education, Culture, Science, Sports and Technology of Japan [18580118]
- Grants-in-Aid for Scientific Research [18580118] Funding Source: KAKEN
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Granzyme A (GrA) is a lymphocyte serine protease that is believed to enter virus-infected cells and growing tumors and induce apoptosis. We found recently that recombinant rat GrA (rGrA) promotes detachment of and interleukin (IL)-8 release from alveolar epithelial A549 cells and suggested that this protease is involved in the pathogenesis of certain inflammatory lung diseases. In the present study, we found that lambda-carrageenan (a sulfated oligosaccharide constituting the cell walls of seaweeds) potently inhibits rGrA-induced detachment and IL-8 release of A549 cells. This sulfated oligosaccharide might be useful for suppressing the development of inflammatory lung diseases in which GrA is thought to be involved.
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