Review
Oncology
Wei-zhao Peng, Xin Liu, Chao-feng Li, Jin Zhao
Summary: In this meta-analysis, LEP gene rs7799039 and ADIPOQ gene rs1501299 were identified as two promising candidate loci in predisposition to breast cancer risk.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Esteban Astiazaran-Symonds, Gina M. Ney, Cecilia Higgs, Leatrisse Oba, Radhika Srivastava, Alicia A. Livinski, Philip S. Rosenberg, Douglas R. Stewart
Summary: This study conducted a systematic review to characterize cancer risk in patients with Costello syndrome (CS). The results showed that over 9% of CS patients had cancer, with rhabdomyosarcoma, bladder cancer, and neuroblastoma being the most common types. Different variants of the HRAS gene were associated with varying cancer and mortality rates. The study highlights the importance of rigorous surveillance and evidence-based guidelines for this high-risk population.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Thuy Thi Nguyen, Diaddin Hamdan, Eurydice Angeli, Jean-Paul Feugeas, Quang Van Le, Frederic Pamoukdjian, Guilhem Bousquet
Summary: Breast cancer brain metastases are a challenging daily practice. This study performed a meta-analysis on genomic data to identify gene alterations associated with metastatic processes in the brain. Six genes with a higher mutation prevalence in brain metastases than in extracerebral metastases were identified, indicating their potential therapeutic implications.
Article
Pathology
Xiaoling Lu, Meitong Liu, Yuxiao Liao, Chao Huang, Longlong Chai, Yuchen Jin, Qiantao Xiong, Bifeng Chen
Summary: The meta-analysis revealed a significant association between SNPs rs2295080, rs17036508, and rs1034528 in the mTOR gene and cancer risk, while target genetic polymorphisms in the mLST8 gene or RPTOR gene may not be associated with cancer risk. Further large-scale and well-designed studies in different ethnic populations are needed to confirm or strengthen these findings.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Oncology
Tommy Nyberg, Marc Tischkowitz, Antonis C. Antoniou
Summary: BRCA1 and BRCA2 pathogenic variants are associated with prostate cancer risk with varying relative risks reported. The heterogeneity in estimates may be influenced by factors such as age, family history, and study-level differences in ethnicity composition. Subgroup analyses suggest risks may be modified by age, ethnicity, and PV location within BRCA2 for future risk estimation studies.
BRITISH JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Amal F. Alshammary, Sabah Ansar, Raed Farzan, Sarah F. Alsobaie, Arwa A. Alageel, Malak Mohammed Al-Hakeem, Imran Ali Khan
Summary: This study investigated the molecular association between rs1501299, rs17846866, and rs2241766 single-nucleotide polymorphisms (SNPs) in the ADIPOQ gene and gestational diabetes mellitus (GDM) in Saudi Arabian women. The results showed a strong association between rs1501299 and rs2241766 SNPs and GDM in women carrying these genetic variations. Multiple logistic regression analysis revealed a negative correlation.
Review
Oncology
Zehan Li, Shengchao Xu, Lin Chen, Shuqi Huang, Xieyida Kuerban, Tianyu Li
Summary: This study investigated the association between ING3 expression and the prognosis of cancer patients. The results showed that high expression of ING3 was negatively associated with advanced TNM stage, lymph node metastasis, and disease-free survival. However, it was not associated with overall survival, tumor size, tumor differentiation, and gender.
FRONTIERS IN ONCOLOGY
(2023)
Article
Genetics & Heredity
Emile R. Chimusa, Joel Defo
Summary: ancMETA, a Bayesian graph-based framework, shows promise in increasing statistical power for meta-analysis of genetic variants underlying complex diseases by deconvoluting gene interactions across human populations. Combining SNPs within genes and genes from multiple GWAS studies helps identify associations with small effect sizes and increases association power. The framework may offer new insights into the genetic basis of diseases and ethnic differences.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Tao Wang, Jiandong Fei, Shuangfa Nie
Summary: GOLPH3 overexpression is associated with tumor stage in colorectal cancer, but cannot serve as a useful biomarker in evaluating the progression of colorectal cancer.
Article
Oncology
Jingjing Li, Wen Bi, Fang Lu, Bei Pan, Mengqiu Xiong, Lubanga Nasifu, Zhenlin Nie, Bangshun He
Summary: This study comprehensively evaluated the prognostic value of E2F1 in cancer patients based on published data. The results showed that higher expression of E2F1 is significantly correlated with unfavorable overall survival and disease-free survival. E2F1 could serve as a prognostic biomarker in cancer patients.
Review
Obstetrics & Gynecology
Majke H. D. van Bommel, Joanna IntHout, Guus Veldmate, C. Marleen Kets, Joanne A. de Hullu, Anne M. van Altena, Marline G. Harmsen
Summary: The use of oral contraceptive pills may increase the risk of breast cancer but decrease the risk of ovarian cancer in BRCA1/2-PV carriers. Tubal ligation also offers protection against ovarian cancer. Counselling for BRCA1/2-PV carriers should be personalized, taking into account genetic and non-genetic factors as well as patient preferences.
HUMAN REPRODUCTION UPDATE
(2023)
Review
Genetics & Heredity
Chuncheng Yi, Tiandong Li, Yajing Shen, Peng Wang, Liping Dai, Jianxiang Shi, Keyan Wang, Changqing Sun, Hua Ye
Summary: This meta-analysis suggests a significant association between ERCC1 rs11615, ERCC1 rs3212986, ERCC2 rs1799793, and ERCC5 rs17655 and CRC susceptibility. However, larger and well-designed studies are needed to confirm these results due to the limited sample size and influence of genetic background.
FRONTIERS IN GENETICS
(2022)
Review
Oncology
Enzo M. Scutigliani, Fernando Lobo-Cerna, Sergio Mingo Barba, Stephan Scheidegger, Przemek M. Krawczyk
Summary: When exposed to heat stress, mammalian cells activate a complex network of processes and genes to protect themselves. However, the understanding of this heat stress response in cancer cells is still limited, with high variability in gene expression changes observed. A meta-analysis of 18 datasets reveals the impact of experimental conditions on gene expression alterations, highlighting the need for more controlled studies to examine the effects of key parameters on global gene expression patterns.
Review
Oncology
Yuanxin Zhang, Xiusen Qin, Rui Luo, Hui Wang, Huaiming Wang, Hongzhi Luo
Summary: Through analyzing data from 25 studies, risk factors for synchronous colorectal peritoneal metastases were identified, including female sex, specific gene positivity, right-sided colon cancer, poorly differentiated grade, specific gene mutation, certain types of carcinoma, lymph node metastasis, depth of tumor invasion, and elevated serum biomarkers.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Wei Xu, Sau Har Lee, Fengjun Qiu, Li Zhou, Xiaoling Wang, Tingjie Ye, Xudong Hu
Summary: The meta-analysis revealed a significant correlation between loss of SMAD4 expression and drug resistance, metastasis, and recurrence in cancer patients. SMAD4 expression could potentially serve as a molecular marker for cancer resistance.
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.