Review
Cardiac & Cardiovascular Systems
Qiu-Lin Li, Jing Tang, Ling Zhao, Amanguli Ruze, Xue-Feng Shan, Xiao-Ming Gao
Summary: In this review, we summarize the structure and main functions of CD74 and focus on its role in cardiovascular diseases. We also discuss potential treatment strategies targeting CD74. Our systematic review fills some knowledge gaps in the field.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cell Biology
Keren David, Gilgi Friedlander, Bianca Pellegrino, Lihi Radomir, Hadas Lewinsky, Lin Leng, Richard Bucala, Idit Shachar, Shirly Becker Herman
Summary: This study investigated the transcriptional and regulatory function of CD74-ICD in normal B cells. It was found that CD74-ICD forms a complex with PAX5 and binds to chromatin at a higher number of sites compared to CLL cells. The CD74-ICD:PAX5 complex also downregulates the expression of the tumor-suppressor gene DMTF1 through transcriptional inhibition.
Article
Pharmacology & Pharmacy
Lin Chen, Zhiqiang Yin, Xing Qin, Xiaoying Zhu, Xu Chen, Gangbing Ding, Dong Sun, Ne N. Wu, Juanjuan Fei, Yaguang Bi, Jingjing Zhang, Richard Bucala, Jun Ren, Qijun Zheng
Summary: This study investigated the role of CD74 deficiency in protecting against cardiac remodeling and contractile dysfunction induced by type 2 diabetes mellitus (T2D). The results showed that CD74 deficiency attenuated T2D-induced damage in mouse hearts and reduced cell death associated with inflammation. Further experiments revealed that CD74 ablation protected against cardiac dysfunction in T2D by regulating NLRP3/pyroptosis-mediated ferroptosis.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Warren B. Nothnick, Amanda Graham
Summary: Endometriosis is a complicated disease characterized by pain and infertility, with unclear pathogenesis and pathophysiology. Rodent models have been developed to study its pathogenesis. In this study, the miR-451a-Mif pathway was evaluated, revealing the role of Mif receptors, Cd74 and Cxcr4, in the pathophysiology of endometriosis.
Article
Cell & Tissue Engineering
Jun-Qin Li, Hui-Jie Jiang, Xiu-Yun Su, Li Feng, Na-Zhi Zhan, Shan-Shan Li, Zi-Jie Chen, Bo-Han Chang, Peng-Zhen Cheng, Liu Yang, Guo-Xian Pei
Summary: This study investigates the mechanism by which Schwann cells promote osteogenesis. The results suggest that Mif is essential for Schwann cells to promote osteogenesis, and its downstream CD74/FOXO1 is also involved in this process. Additionally, Schwann cells regulate amino acid metabolism and lipid metabolism in preosteoblasts.
STEM CELLS INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Annette Ives, Didier Le Roy, Charlotte Theroude, Juergen Bernhagen, Thierry Roger, Thierry Calandra
Summary: The cytokine MIF plays a chemokine-like role in promoting the migration of dendritic cells (DCs) by activating the Src/PI3K signaling pathway and myosin II complexes. MIF contributes to the recruitment of DCs to draining lymph nodes through autocrine and paracrine activities acting via CD74. These findings indicate that MIF is crucial for DC motility and trafficking.
Article
Medicine, Research & Experimental
Lifeng Qin, Jiawu Tan, Xiaoping Lv, Jiqiao Zhang
Summary: This study confirmed the role of hepatic stellate cells (HSCs) autophagy and the MIF/CD74 signaling pathway in the development of liver fibrosis, and demonstrated the potential anti-fibrotic effect of vanillic acid (VA) through in vivo and in vitro experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Bibiana Quirant-Sanchez, Oriol Plans-Galvan, Ester Lucas, Eduard Argudo, Eva Maria Martinez-Caceres, Fernando Armestar
Summary: The early identification and treatment of at-risk patients with sepsis is crucial for reducing mortality. This study assessed the correlation between HLA-DR expression on monocytes ((M)HLA-DR ratio), sepsis index (CD64 expression on neutrophils/(M)HLA-DR ratio), C-reactive protein (CRP), and sepsis development. Biomarkers were tested in 77 critically ill patients over a period of 15 days. Most patients (71%) developed sepsis within 4.2±1.3 days after admission. On day 3, patients who subsequently developed sepsis had lower (M)HLA-DR+ levels and higher sepsis indexes compared to those who did not develop sepsis. The (M)HLA-DR ratio recovered slowly before day 6, while the sepsis index remained elevated up to day 9 in septic patients. Optimal cut-offs for predicting sepsis development were CRP levels > 106.90 mg/mL and (M)HLA-DR expression rate < 72.80%. Periodic monitoring of (M)HLA-DR expression, CRP, and sepsis index may help identify high-risk sepsis patients in the ICU.
Article
Medicine, General & Internal
Gabriela Athziri Sanchez-Zuno, Richard Bucala, Jorge Hernandez-Bello, Ilce Valeria Roman-Fernandez, Mariel Garcia-Chagollan, Ferdinando Nicoletti, Monica Guadalupe Matuz-Flores, Samuel Garcia-Arellano, Judith Alejandra Esparza-Michel, Sergio Cerpa-Cruz, Edsaul Emilio Perez-Guerrero, Jose Francisco Munoz-Valle
Summary: Macrophage migration inhibitory factor (MIF) plays a significant role in the pathogenesis of rheumatoid arthritis (RA). This study explored the expression of CD74, CXCR2, CXCR4, and CXCR7, as well as the levels of soluble CD74 (sCD74), in relation to the clinical activity of RA. The results suggest that sCD74 may act as a decoy receptor for MIF and negatively regulate its signaling, while CXCR7 functions as a scavenger-type receptor to prevent endocytosis and degradation of CXCR4 under inflammatory conditions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Genetics & Heredity
Maria Tsakiroglou, Anthony Evans, Munir Pirmohamed
Summary: Diagnostics require precision and predictive ability in order to be clinically useful. Integration of multi-omic with clinical data is crucial for understanding disease pathogenesis and diagnosis. However, interpreting large amounts of information at the individual level requires sophisticated computational tools. RNA, the most dynamic component in -omics technologies, carries regulatory information that is least utilized in clinical diagnostics. Gene expression-based tests can capture genetic and non-genetic heterogeneity and have been implemented in certain diseases. Transcriptomics has potential for patient stratification in clinical environments and clinical trials. In this review, the current clinical applications, challenges, and approaches for implementing transcriptomics in cancer and infection fields are discussed.
FRONTIERS IN GENETICS
(2023)
Article
Immunology
Jaana Westmeier, Annika Brochtrup, Krystallenia Paniskaki, Zehra Karakoese, Tanja Werner, Kathrin Sutter, Sebastian Dolff, Andreas Limmer, Daniela Mittermueller, Jia Liu, Xin Zheng, Tetiana Koval, Igor Kaidashev, Marc Moritz Berger, Frank Herbstreit, Thorsten Brenner, Oliver Witzke, Mirko Trilling, Mengji Lu, Dongliang Yang, Nina Babel, Timm Westhoff, Ulf Dittmer, Gennadiy Zelinskyy
Summary: T cells in COVID-19 patients express receptors for macrophage migration inhibitory factor (MIF), which might contribute to the severity of pulmonary pathologies and prognosis. The expression of CD74 on T cells is higher in COVID-19 patients compared to healthy controls, and the expression of CXCR2 and CXCR4 increases upon SARS-CoV-2 infection. CD74+ T cells have a central memory phenotype early in infection, while cells with an effector and effector memory phenotype arise later during infection. Furthermore, CD74+ T cells produce more cytotoxic molecules and proliferation markers.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Pawel Szczesniak, Tamara Henke, Suada Froehlich, Uwe Plessmann, Henning Urlaub, Lin Leng, Richard Bucala, Robert Grosse, Andreas Meinhardt, Joerg Klug
Summary: MIF and D-DT are pro-inflammatory cytokines that coordinate various biological activities, especially cell migration. The study found that MIF can modulate cell migration independently of CD74/CD44, with its pro-migratory effects depending on multiple factors.
JOURNAL OF CELL SCIENCE
(2021)
Article
Oncology
Benjamin L. Woolbright, Ganeshkumar Rajendran, Erika Abbott, Austin Martin, Sarah Amalraj, Katie Dennis, Xiaogang Li, Joshua Warrick, John A. Taylor
Summary: MIF2 functions similarly to MIF1 in promoting bladder cancer development and progression, partly through CD74. Dual inhibition of MIF homologs is more effective in reducing tumor burden in bladder cancer compared to single inhibition of MIF1.
JOURNAL OF PATHOLOGY
(2023)
Article
Chemistry, Analytical
Chenwen Shao, Christian Hedberg, Yong Qian
Summary: A novel activity-based probe, TPP2, was reported for direct labeling and imaging of endogenous MIF activity within live cells and in a mouse model of liver cancer. TPP2 allows for the dynamic monitoring of intracellular MIF activity and the identification of liver cancer with high sensitivity and selectivity, providing a promising new imaging approach for elucidating MIF-related biological functions in liver cancer.
ANALYTICAL CHEMISTRY
(2021)
Review
Immunology
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri, Normohammad Arefian
Summary: Sepsis results from inflammatory response to microbial agents and can lead to multiple organ system failure. Non-coding RNAs such as lncRNAs, miRNAs, and circRNAs have been found to play a role in the pathogenesis of sepsis-related complications.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.