Article
Cell Biology
Bing-Ru Yan, Taoyingnan Li, Etienne Coyaud, Estelle M. N. Laurent, Jonathan St-Germain, Yuhuan Zhou, Peter K. Kim, Brian Raught, John H. Brumell
Summary: The protein C5orf51 plays a crucial role in regulating the activity of RAB7A during mitophagy, facilitating the shuttle of RAB7A between late endosomes and mitochondria. Depletion of C5orf51 leads to compromised localization of RAB7A on depolarized mitochondria, degradation by the proteasome, and inhibition of ATG9A recruitment to depolarized mitochondria.
Article
Cell Biology
Zhuofu Ni, Xiaodong Cheng
Summary: EPAC proteins are only present in multicellular Metazoa, with EPAC1 only associated with chordates and EPAC2 spanning the entire animal kingdom. EPAC1 has undergone more selection and evolved faster than EPAC2.
Editorial Material
Biochemistry & Molecular Biology
Jianjun Duan, David G. Lambright
Summary: The article explores the structural basis for Sar1 activation by the Sec12 guanine nucleotide exchange factor during COPII vesicle biogenesis at the endoplasmic reticulum.
Article
Oncology
Xin Zhang, Liangliang Ren, Junhua Wu, Rongni Feng, Yunyang Chen, Ronggang Li, Meimei Wu, Mingzhu Zheng, Xing Gui Wu, Wanjun Luo, Hongle He, Yanming Huang, Miaoling Tang, Jun Li
Summary: ARHGEF37 is upregulated in HCC and associated with tumor invasiveness, pulmonary metastasis and poor prognosis. Overexpression of ARHGEF37 enhances HCC cell extravasation and metastasis by promoting cell adhesion and migration. ARHGEF37 activates Cdc42 to promote invadopodia formation in HCC cells, disrupting the interaction between endothelial cells and pericytes.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Aaron M. N. Joiner, Ben P. Phillips, Kumar Yugandhar, Ethan J. Sanford, Marcus B. Smolka, Haiyuan Yu, Elizabeth A. Miller, J. Christopher Fromme
Summary: The study revealed the regulation of Rab1 activation by the TRAPPIII complex, with the Trs85 subunit serving as a membrane anchor for the entire complex via its amphipathic helix. These findings provide a structural understanding of Rab activation on organelle and vesicle membranes.
Article
Biochemistry & Molecular Biology
Maria K. Mateyak, Dongming He, Pragati Sharma, Terri Goss Kinzy
Summary: Phosphorylation of eEF1A affects its function, and mutation analysis confirms the importance of several phosphorylation sites, with the S289D mutant's activity being influenced by eEF1B alpha.
Article
Multidisciplinary Sciences
Xin Yong, Guowen Jia, Zhe Liu, Chunzhuang Zhou, Jiamin Yi, Li Chen, Lu Chen, Yuan Wang, Qingxiang Sun, Daniel D. Billadeau, Zhaoming Su, Da Jia
Summary: In this study, the structure of the Drosophila Mon1-Ccz1-RMC1 complex was determined using cryogenic-electron microscopy. RMC1 acts as a scaffolding subunit and binds to both Mon1 and Ccz1, explaining the binding specificity of the complex. The assembly of RMC1 with Mon1-Ccz1 is required for cellular RAB7A activation, autophagic functions, and organismal development in zebrafish.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Xiang Shu, Qin Zhou, Xiaohui Sun, Michelle Flesaker, Xingyi Guo, Jirong Long, Mark E. Robson, Xiao-Ou Shu, Wei Zheng, Jonine L. Bernstein
Summary: This study identified 98 proteins that may have potential causal associations with the risk of breast cancer subtypes. The associations of ICAM1, PLA2R1, and TXNDC12 varied significantly across the subtypes. These findings contribute to understanding the heterogeneity in the etiology of different subtypes of breast cancer and may aid in personalized risk assessment of the disease.
BRITISH JOURNAL OF CANCER
(2022)
Article
Cell Biology
Yitian Guo, Judeah Negre, Gary Eitzen
Summary: When mast cells are stimulated by antigens, they release preformed inflammatory mediators through a process called degranulation. A protein called GEF-H1 is found to be activated during antigen stimulation and plays a role in activating RhoA to promote mast cell spreading and focal adhesion formation. Depletion of GEF-H1 leads to reduced cell spreading, granule movement, and exocytosis, which can be restored by expressing a constitutively active RhoA mutant. Inhibition of Syk kinase, a protein involved in the Fc epsilon RI signaling pathway, also blocks GEF-H1 activation and suppresses cell spreading, granule movement, and exocytosis.
Article
Cell Biology
Justyna M. Meissner, Katarina Akhmetova, Tomasz Szul, Ekaterina G. Viktorova, Bingdong Sha, Jay M. Bhatt, Eunjoo J. Lee, Richard A. Kahn, George A. Belov, Igor Chesnokov, Elizabeth Sztul
Summary: In this study, we identified the essential role of the HDS3 domain in GBF1 membrane association in mammalian cells and its critical function during Drosophila melanogaster development. We characterized the interdomain arrangements of GBF1 by electron microscopy and proposed models for GBF1 engagement on the membrane.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Agronomy
Munsif Ali Shad, Yixian Wang, Hui Zhang, Shanshan Zhai, Abdullah Shalmani, Yibo Li
Summary: Using in-silico analysis and transgenic approaches, the evolutionary relationships and functions of GEF and GDI genes in rice were dissected. These genes were highly expressed in panicles, hulls, and stamens. They interacted with grain-size protein GS3, playing a crucial role in the regulation of grain size and plant architecture.
Article
Medicine, General & Internal
Chiung-Jung Wen, Chin-Hao Chang, Chin-Ying Chen, Jen-Kuei Peng, Hsien-Liang Huang, Pei-Ni Chuang, Ching-Yu Chen, Jaw-Shiun Tsai
Summary: The study found that the mRNA levels of ICAM-1 and TLR4 in PBMCs are significantly higher in older adults compared to younger adults. TLR4 is an independent factor affecting the expression of ICAM-1 in PBMCs. This suggests that ICAM-1 and TLR4 in PBMCs could be potential biomarkers for the ageing process.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Eugene Won Park, Katsuhisa Kawai, Youhei Egami, Nobukazu Araki
Summary: This study identified the intracellular localization of DENND1B to gathered line structures, which was dependent on a specific region located in the C-terminus of the protein. The gathered line structures were partially associated with microtubules but not with F-actin, with F-actin bundles surrounding the assembly. DENND1B was found to play a new role in the regulation of cell migration.
HISTOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Cell Biology
Eun-Ji Lim, Jae-Hyeok Kang, Yeon-Ju Kim, Seungmo Kim, Su-Jae Lee
Summary: ICAM-1 is a potential therapeutic target for colorectal cancer (CRC) that enhances treatment effectiveness by promoting the c-MET-SRC signaling axis. Treatment with antibodies targeting ICAM-1 can reduce metastasis and angiogenesis in CRC.
CELL DEATH & DISEASE
(2022)
Article
Agriculture, Dairy & Animal Science
Linglian Kong, Yuanli Cai, Xue Pan, Chuanpi Xiao, Zhigang Song
Summary: The study found that glycerol monolaurate (GML) can improve intestinal morphology, enhance antioxidant capacity, and exert its effects by alleviating inflammatory responses and modulating NF-kB signaling.
Article
Dermatology
Minfei Jiang, Aobuliaximu Yakupu, Haonan Guan, Jiaoyun Dong, Yingkai Liu, Fei Song, Jiajun Tang, Ming Tian, Yiwen Niu, Shuliang Lu
Summary: MGO forms protein adducts that cause macrophage dysfunction, a common occurrence in diabetes. Pyridoxamine scavenges MGO to ameliorate this dysfunction, promoting wound healing. Pyridoxamine could be used therapeutically to treat non-healing diabetic wounds.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Dermatology
Haonan Guan, Di Zhang, Xian Ma, Yechen Lu, Jiaoyun Dong, Yiwen Niu, Yingkai Liu, Shuliang Lu, Jiping Xu, Jiajun Tang
Summary: The study found that fully ablative CO2 laser debridement has several advantages over routine sharp surgical debridement in treating chronic wounds. It is superior at ameliorating wound status, reducing wound area, and significantly reducing the time-to-heal for chronic wounds, without causing any adverse events.
LASERS IN SURGERY AND MEDICINE
(2022)
Article
Materials Science, Multidisciplinary
Xing-Yuan Chen, Kun-Ren Su, Shi-Wu Ling, Cha-Sen Li, Guo-Xia Lai, Guo-Ping Luo, Xiang-Fu Xu, Hong Ji, Jia-Jun Tang
Summary: The double perovskite multiferroic materials Bi2FeCrO6 show significant improvement in magneto-electric, photovoltaic, and photocatalytic performance compared to BiFeO3. By using density functional theory, a novel double perovskite multiferroic material In2FeX (X = V, Cr, Mn, Co, and Ni) O6 is designed to achieve superior performance in ferroelectricity, magnetism, photovoltaics, and photocatalysis. The calculation results indicate that In2FeXO6 (X = V or Cr) O-6 could be a metastable multiferroic material with high ferroelectric polarization strength, driven by the interaction between In-O ions. In2FeVO6 exhibits a suitable bandgap and high photoelectric conversion efficiency as an excellent ferroelectric photovoltaic material. It can also absorb visible light to drive water splitting for hydrogen production under tensile strain.
RESULTS IN PHYSICS
(2022)
Article
Medicine, General & Internal
Caiting Chu, Ming Liu, Yuzhen Zhang, Shuhui Zhao, Yaqiong Ge, Wenhua Li, Chengjin Gao
Summary: This study developed an assessment system for intraoperative risks based on MRI-based radiomics and clinical data analysis. The models built using this system successfully predicted the selection of placenta removal protocols and the prediction of intraoperative blood loss, showing promising clinical utility.
Article
Immunology
Shaowei Jiang, Jing Ma, Shan Ye, Connor Meaney, Timothy Evan Moore, Shuming Pan, Chengjin Gao
Summary: This study investigated the relationship between genetic polymorphisms in TLR2, TLR4, and platelets in Chinese patients with sepsis. The findings suggest that the rs111200466 SNP in TLR2 and the rs11536889 SNP in TLR4 are associated with thrombocytopenia and disseminated intravascular coagulation (DIC).
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Yingying Huang, Shaowei Jiang, Wenjie Li, Yiwen Fan, Yuxin Leng, Chengjin Gao
Summary: The RAAS scoring system, based on RDW, AGE, SOFA, and APACHE II scores, is a novel and reliable indicator for predicting short-term and medium-term mortality in patients with sepsis.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Surgery
Haonan Guan, Yixin Pan, Peng Huang, Jiajun Tang, Bomin Sun, Shuliang Lu
Summary: This study aimed to evaluate the efficacy and safety of pedicled omental transposition in the treatment of recurrent skin erosion following deep brain stimulation. The results showed that patients in the pedicled omental transposition group had no symptoms during follow-up, and had significantly lower recurrence and explanation rates. This new surgical method offers an effective and safe solution for saving deep brain stimulation systems in patients with skin erosions.
INDIAN JOURNAL OF SURGERY
(2023)
Article
Medicine, General & Internal
Di Zhang, Wei Dong, Haonan Guan, Aobuliaximu Yakupu, Hanqi Wang, Liuping Chen, Shuliang Lu, Jiajun Tang
Summary: The purpose of this study is to predict the occurrence and prognosis of diabetic foot ulcers (DFUs) using clinical and lower extremity computed tomography angiography (CTA) data and an artificial neural networks (ANN) model. The study found that the ANN model can accurately and reliably predict the occurrence and prognosis of DFUs, providing clinicians with a novel technical tool.
Article
Energy & Fuels
Pei Wang, Jiajun Tang, Zhi Zhang, Yating Li, Hao Wu, Chao Ji, Zhemin Lin, Jien Ma, Hui Qi, Weishi Zhang, Li Yang, Zhenzhi Lin
Summary: This study proposes a bi-level bidding strategies optimization model to coordinate the bidding strategies of power generation companies in the electricity market and carbon emission market, aiming to maximize their benefits. Simulation results show that the carbon emission penalty price affects the strategies and purchasing behavior of power generation companies.
Article
Biochemistry & Molecular Biology
Deyin Wang, Xiaohui Wen, Dong Zhang, Jiajun Tang
Summary: In this study, the effect of arms and shear flow on the dynamical and structural properties of the comb long-chain branched (LCB) polymer with dense arms was investigated using hybrid multi-particle collision dynamics (MPCD) and molecular dynamics (MD) methods. The results show that the LCB polymer undergoes periodic stretched-folded-stretched state transition and rotation, with the arms playing a role in stabilizing the polymer's motion. The impact induced by random and fast motions of arms and backbone decreases as the shear rate increases. The length of the arms and the conformational distribution are found to be important factors affecting the rotation period of the LCB polymer. The structural properties analysis reveals that the changes in gyration of the LCB polymer are in accordance with its rolling behavior, and the resistance to configuration expansion against the imposed flow field is stronger for the comb polymer with shorter arms. Additionally, with increasing arm length, the comb polymer transitions from linear-polymer-like to capsule-like behavior in shear flow.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Deyin Wang, Xiaohui Wen, Dong Zhang, Xinguan Tan, Jiajun Tang
Summary: The stretching dynamics and dynamical behaviors of individual branched ring polymer (BRP) were studied in steady shear flow. The nonmonotonic increase of polymer size with increasing branch length was observed. A universal power law described the decrease of alignment angle during the first downward phase. Tumbling and tank-treading motions were reflected by periodic and non-periodic changes of the polymer's ring backbone.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Caiting Chu, Lijun Wang, Yuhang Wu, Huajun Li, Shanshan Xu, Liya Zhang, Quanhua Liu, Xi Zhang, Lei Xu, Chengjin Gao, Lisu Huang
Summary: This study analyzed low-dose computed tomography findings to assess the severity and progression of childhood Mycoplasma pneumoniae infection. The results showed that lobar consolidation is a stable and reliable CT feature that can be used to evaluate the severity of Mycoplasma pneumoniae pneumonia (MPP) in children. The number of lobes of consolidation was positively correlated with fever duration and the length of hospital stay, indicating its potential for predicting disease progression. Therefore, low-dose computed tomography is recommended for children with severe MPP.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Medicine, General & Internal
Shaowei Jiang, Yang Wang, Liang Chen, Honghua Mu, Connor Meaney, Yiwen Fan, Janesh Pillay, Hairong Wang, Jincheng Zhang, Shuming Pan, Chengjin Gao
Summary: This study investigates the associations among serum levels of PAI-1, PAI-1 gene polymorphisms, immunological indicators, and clinical outcomes in septic patients. The results suggest that genetic polymorphisms of PAI-1 can affect serum levels of PAI-1, which in turn may influence mortality by affecting neutrophil activity.
CHINESE MEDICAL JOURNAL
(2023)
Article
Endocrinology & Metabolism
Ning Ning, Juan Li, Wenwu Sun, Chaoping Ma, Jiaoyan Li, Huiqiu Sheng, Ying Chen, Bing Zhao, Jiyuan Zhang, Jiyue Zhu, Chengjin Gao, Enqiang Mao
Summary: This study evaluates the association between different subtypes of NTIS and outcomes in septic patients. The results show that NTIS is significantly associated with 30-day mortality, and the decrease in FT3 together with FT4 or TSH is associated with an increased risk of death.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Dermatology
Jiajun Tang, Haonan Guan, Wei Dong, Yingkai Liu, Jiaoyun Dong, Lifang Huang, Jingqi Zhou, Shuliang Lu
Summary: The clinical efficacy of compound polymyxin B ointment for treating chronic refractory wounds was investigated in this study. The findings showed that after thorough debridement, compound polymyxin B ointment can effectively reduce wound infection and accelerate the healing time.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.