Review
Medicine, General & Internal
Mingcai Wu, Mengjun Tao, Quanhai Wang, Xiaohua Lu, Hui Yuan
Summary: Through network meta-analysis, the study found that the combination therapy of ETN and MTX may have the best efficacy, outperforming other drugs. Compared to placebo, ETN, ETN + MTX, and ANA were also effective in treating RA.
Review
Health Care Sciences & Services
Evanthia P. Perikleous, Paschalis Steiropoulos, Evangelia Nena, Emmanouil Paraskakis
Summary: Childhood asthma is a common and complex chronic condition in children, and the management of severe asthma remains challenging. The use of biologic agents has shown promise in treating severe childhood asthma, but long-term effects are still unclear. Further research is needed to determine the most effective biologic agents and predictors of treatment response for pediatric patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Ahmed I. Mourad, Robert Gniadecki
Summary: Drug survival studies in psoriasis assessed the comparative effectiveness of biologics like ustekinumab, adalimumab, etanercept, infliximab, secukinumab, and ixekizumab in real-world settings. Results showed ustekinumab had the longest persistence, with adalimumab outperforming etanercept and infliximab at 5 years. The estimated pooled 2- and 5-year drug survival rates can serve as a useful tool for patient communication and clinical decision-making.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Se Hee Kim, Hae-Rim Kim, Sang-Heon Lee, Kichul Shin, Hyoun-Ah Kim, Hong Ki Min
Summary: This study aimed to evaluate the drug efficacy and retention rate of bDMARDs in late-onset ankylosing spondylitis (LOAS) compared to young-onset ankylosing spondylitis (YOAS). The results showed that patients with LOAS had more severe disease-associated parameters and were less likely to achieve treatment efficacy compared to YOAS patients.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Angelo Ruggiero, Fabrizio Martora, Vincenzo Picone, Laura Marano, Gabriella Fabbrocini, Claudio Marasca
Summary: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with unclear pathogenesis. Recent research has improved our understanding of the mechanisms behind HS lesions, including follicular occlusion and rupture, immune response activation, and imbalanced cytokine production. Paradoxical HS occurrences have been increasingly reported during treatment with biologic drugs.
Review
Chemistry, Physical
Genna Braverman, S. Louis Bridges, Larry W. Moreland
Summary: This article summarizes the current evidence base for biologic tapering in RA, outlines real-world outcomes findings, reviews important contextual factors relevant to therapy deescalation, such as cost-effectiveness considerations and patient perspectives, and concludes by summarizing current guidelines.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2022)
Review
Dermatology
Lauren Schaefer, Nneka Comfere, Olayemi Sokumbi
Summary: This systematic review investigated the development of cutaneous T-cell lymphoma (CTCL) following treatment with a biologic agent. The study found 62 patients who developed CTCL after exposure to a biologic agent, with 44% being Caucasian and a median age at diagnosis of 56 years. Mycosis fungoides (65%) and Sezary syndrome (10%) were the most common subtypes of CTCL diagnosed. The need for more methodologically robust studies to definitively elucidate the role of biologic agents in CTCL development was highlighted.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Article
Medicine, General & Internal
Matthew C. Baker, Yingjie Weng, Robert Fairchild, Neera Ahuja, Nidhi Rohatgi
Summary: The study found that patients receiving home biologic infusions were more likely to have adverse events requiring escalation of care, suggesting that the safety implications of administering biologic infusions at home need to be further assessed.
Review
Gastroenterology & Hepatology
Albert J. Czaja
Summary: Biologic agents show promise in treating refractory autoimmune hepatitis. This review presents the types and results of biologic therapy, highlights opportunities for improvement and expansion, and emphasizes the need for comparative clinical trials. However, these agents may also have serious side effects, making further research and evaluation necessary.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Dermatology
V. Sanchez-Garcia, R. Hernandez-Quiles, E. de-Miguel-Balsa, A. Gimenez-Richarte, J. M. Ramos-Rincon, I. Belinchon-Romero
Summary: This study reviewed 51 observational studies involving 739 pregnancies exposed to biologics for psoriasis. The results showed that exposure to biologics during pregnancy was not associated with an increased risk of miscarriage/abortion or congenital malformations, with similar rates to the general population.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Medicine, General & Internal
Bruna de Oliveira Ascef, Matheus Oliveira Almeida, Ana Cristina de Medeiros-Ribeiro, Danieli Castro Oliveira de Andrade, Haliton Alves de Oliveira Junior, Patricia Coelho de Soarez
Summary: In this systematic review and meta-analysis, biosimilars of adalimumab, infliximab, and etanercept were found to have clinically equivalent treatment effects compared with their reference biologics for the treatment of rheumatoid arthritis (RA).
Review
Dermatology
Alessio Gambardella, Gaetano Licata, Anne Sohrt
Summary: Dose adjustment of biologics for moderate-to-severe plaque psoriasis is common in clinical practice. Escalation of doses is more frequently reported than reduction, with different medications showing varying patterns of dose adjustment.
DERMATOLOGY AND THERAPY
(2021)
Review
Dermatology
A. Al-Hammadi, Z. Ruszczak, G. Magarinos, C-Y Chu, Y. El Dershaby, N. Tarcha
Summary: Continuous treatment with biologic agents is more effective than intermittent treatment for moderate-to-severe psoriasis, but intermittent treatment can be a viable option for patients who are unable or unwilling to maintain continuous therapy. Most patients are able to re-establish disease control following re-treatment, and adverse reactions during re-treatment are similar to those observed during continuous dosing.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Oncology
Aditi Mulgaonkar, Roy Elias, Layton Woolford, Bing Guan, Kien Nham, Payal Kapur, Alana Christie, Vanina T. Tcheuyap, Nirmish Singla, I. Alex Bowman, Christina Stevens, Guiyang Hao, James Brugarolas, Xiankai Sun
Summary: The study demonstrates that immunoPET with [89Zr]Zr-DFO-ATZ is significantly associated with PD-L1 IHC assays and can assess the heterogeneous distribution of PD-L1 expression. Patient studies suggest that the PD-L1 signal may influence responsiveness to ICI.
CLINICAL CANCER RESEARCH
(2022)
Article
Allergy
Laura Tenero, Giorgio Piacentini
Summary: The introduction of monoclonal antibodies in the past two decades has brought about significant changes in the treatment of allergic diseases, particularly in pediatric patients. The use of monoclonal antibodies allows for more personalized treatments based on the inflammatory pattern.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Review
Dermatology
D. Torchia
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2015)
Letter
Dermatology
Daniele Torchia, Andrea Amorosi, Pietro Cappugi
DERMATOLOGIC SURGERY
(2015)
Letter
Dermatology
Daniele Torchia, Lawrence A. Schachner
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2015)
Article
Dermatology
Daniele Torchia, Lawrence A. Schachner
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2015)
Review
Dermatology
D. Torchia, R. Happle
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2015)
Letter
Dermatology
D. Torchia
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2020)
Review
Dermatology
D. Torchia
Summary: MVN syndrome is a rare condition characterized by mixed vascular naevus with soft tissue hypotrophy or central nervous system abnormalities. The differential diagnoses of NVM and its syndrome include vascular twin naevi and other types of vascular naevi.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Letter
Dermatology
Daniele Torchia, Rudolf Happle
EUROPEAN JOURNAL OF DERMATOLOGY
(2020)
Review
Dermatology
Daniele Torchia
Summary: Nevus comedonicus (NC) syndrome is a rare condition with three morphological variants. It is mainly characterized by ocular, skeletal, and neural abnormalities, and its pathogenesis is related to a postzygotic mutation of the NEK9 gene.
PEDIATRIC DERMATOLOGY
(2021)
Letter
Dermatology
Daniele Torchia
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
(2022)
Letter
Dermatology
Daniele Torchia
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Letter
Dermatology
Daniele Torchia
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Letter
Oncology
Daniele Torchia
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Dermatology
Daniele Torchia
Summary: Phacomatosis pigmentovascularis involves a group of disorders characterized by the coexistence of segmental pigmented nevus of melanocytic origin and segmental capillary nevus. Confusion over the names and definitions of certain types of phacomatosis and misplaced diagnoses have been found in published cases. componentName: Phacomatosis spilorosea predominantly affects the musculoskeletal system with potential neurological manifestations, while Phacomatosis melanorosea is sometimes associated with additional cutaneous lesions and has a relevant association with brain vascular malformations, appearing to be less severe overall.
ACTA DERMATOVENEROLOGICA ALPINA PANNONICA ET ADRIATICA
(2021)
Review
Dermatology
Daniele Torchia, Rudolf Happle
EUROPEAN JOURNAL OF DERMATOLOGY
(2019)
