Article
Biochemical Research Methods
Yingying Wen, Le Jin, Dongyan Zhang, Liyue Zhang, Chen Xie, Dongyu Guo, Yang Wang, Liyin Wang, Miaomiao Zhu, Jianping Tong, Ye Shen
Summary: This study identified dysregulated protein signatures in the sclera of guinea pigs in response to wavelength defocus, revealing potential mechanisms contributing to refractive development and myopia induction. It also found overlap between dysregulated proteins in response to wavelength defocus and genes causing myopia in humans, suggesting a link between scleral proteomics and myopia formation. The results provide insights into the mechanisms of myopia and wavelength defocus induced ametropia.
JOURNAL OF PROTEOMICS
(2021)
Article
Ophthalmology
Tian Tian, Leilei Zou, Shu Wang, Rui Liu, Hong Liu
Summary: This study investigated the role of retinal dopamine (DA) in controlling the effects of wavelength and temporal frequency on refractive development. The results suggest that the retinal DOPAC/DA ratio is correlated with ocular growth, potentially explaining myopic shifts from long wavelength and low frequency light exposure, while different biochemical pathways may contribute to hyperopic shifts from short wavelength light.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Manrong Yu, Wangyuan Liu, Bingjie Wang, Jinhui Dai
Summary: The study showed that guinea pigs exposed to short-wavelength light were less likely to develop myopia compared to those under white light, with shorter axial length and lower retinal RA levels. Oral RA supplementation accelerated eye elongation, but the synthesis inhibitor citral equally slowed down eye growth under different light conditions, with no significant reduction in retinal RA levels.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Liqin Jiang, Xinyu Liu, Lei Zhou, Joanna M. Fianza Busoy, Myo Thu Khine, Yee Shan Dan, Mengyuan Ke, Noel A. Brennan, Karen J. Catbagan, Leopold Schmetterer, Veluchamy A. Barathi, Quan Hoang
Summary: This study aimed to investigate the relationship between choroidal characteristics and susceptibility to myopia development. The results showed that greater choroidal thickness could protect against myopia, while lower choroidal thickness was associated with a higher susceptibility to myopia development. Dysfunction of the choroidal vascular system may be the underlying mechanism.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Yifang Yang, Junshu Wu, Defu Wu, Qi Wei, Tan Zhong, Jun Yang, Xiaowei Yang, Meizhen Zeng, Xingwu Zhong
Summary: Among the 3 different administration methods, intravitreal injection of brimonidine was the most effective in slowing myopia progression in the FD guinea pig model. Intravitreal brimonidine at 4 mu g/mu L significantly reduced the development of FD myopia in guinea pigs. Expression levels of the Col1a1 and Mmp2 genes were significantly increased in the retinal tissues of the FD-Inj-Br group.
Article
Cell Biology
Yajun Wu, Yuliang Feng, Jiasong Yang, Hua Fan, Zitong Yu, Xiaolin Xie, Yumeng Dai, Xin Huang, Wensheng Li
Summary: The aim of this study was to investigate the effects of exogenous retinoic acid (RA) on intraocular parameters, especially choroidal thickness (CT) and retinal thickness (RT), in guinea pigs with form deprivation myopia (FDM). After 4 weeks, it was found that RA can increase the refractive error, axial length, and intraocular pressure of FDM guinea pigs, and might aggravate the retinal thinning. Citral, on the other hand, can inhibit these changes, but may not affect the thickness of the choroid.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Ophthalmology
Xuan Zhou, Sen Zhang, Fan Yang, Yaozhen Yang, Qin Huang, Chengjie Huang, Jia Qu, Xiangtian Zhou
Summary: Reducing choroidal blood perfusion in guinea pigs can induce myopia development and increase scleral hypoxia and expression of alpha-SMA protein. This study suggests that choroidal blood perfusion reduction could be a potential biomarker for early detection of myopia development in future clinical trials.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Qian Fu, Yue Zhang, Linji Chen, Mengmeng Dong, Wenyu Tang, Si Chen, Jia Qu, Xiangtian Zhou, Zhina Zhi
Summary: This study establishes a model for near work myopia induced by short viewing distance in guinea pigs and evaluates the effect of viewing distance on myopia development. The findings suggest that short viewing distance could be a risk factor for myopia and provide a useful model for studying the underlying mechanisms.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Pinghui Wei, Guoge Han, Meiqin He, Yan Wang
Summary: This study aimed to investigate the changes in retinal neurotransmitters and the role of the dopamine D2 receptor (D2R) pathway in regulating myopic refractive state. The results showed that after forced occlusion for 4 weeks, dopamine (DA) and γ-aminobutyric acid (GABA) concentrations decreased, while glutamate (Glu), 3-methoxytyramine (3-MT), and glycine concentrations increased, accompanied by an increase in myopic refraction and axial length (AL). Treating with D2R antagonist sulpiride increased glycine and DA levels, while decreasing 3-MT and Glu levels, accompanied by a decrease in myopic refraction and AL. The ratio of Glu to GABA (RGG) represents the balance between excitatory and inhibitory neurotransmitters, and changes in RGG correlated with changes in AL.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Physiology
Qin Yang, Qing Qing Tan, Chang Jun Lan, Bo Zhen Lv, Gui Mei Zhou, Wei Qi Zhong, Zhi Ming Gu, Yu Mei Mao, Xuan Liao
Summary: In the study of form deprivation myopia guinea pigs, it was found that the expression of the KCNQ5 gene in the retina was significantly downregulated, K+ concentration increased, M current density decreased, and ocular axis elongated. It is suggested that KCNQ5 may play a role in the process of myopia, and intervention of potassium channels may contribute to the prevention and control of myopia.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Hanyu Zhang, Carly S. Y. Lam, Wing-Chun Tang, Myra Leung, Hua Qi, Paul H. Lee, Chi-Ho To
Summary: The aim of this study is to investigate the influence of baseline relative peripheral refraction (RPR) on myopia control effects in Chinese myopic children wearing Defocus Incorporated Multiple Segments (DIMS) lenses. The results showed that baseline myopic RPR was associated with more myopic progression and greater axial elongation in the DIMS group, but not in the single vision (SV) group. Children with baseline myopic RPR in the DIMS group had statistically significant more myopia progression and axial elongation compared to those with baseline hyperopic RPR.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Zhina Zhi, Jing Xiang, Qian Fu, Xiaomeng Pei, Dengke Zhou, Yuqing Cao, Liqin Xie, Sen Zhang, Si Chen, Jia Qu, Xiangtian Zhou
Summary: The study aimed to determine the role of retinal gap junctions via connexin 36 and horizontal cell coupling in emmetropization. Results indicated that GJs containing Cx36 play a role in emmetropization and form deprivation myopia, while HC-HC coupling in the OPL may not significantly contribute to emmetropization and myopia development.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Baodi Deng, Wentao Li, Ziping Chen, Junwen Zeng, Feng Zhao
Summary: This study investigated the effects of temporal bright light at very low frequencies on lens-induced myopia progression. The results showed that low frequency light effectively inhibited myopia progression.
Article
Ophthalmology
Swapnil Thakur, Rohit Dhakal, Pavan K. Verkicharla
Summary: Exposure to red and green light resulted in axial elongation, while blue light inhibited axial elongation in human eyes. The impact of specific wavelength exposure on children and its application in myopia control warrants further investigation.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Yaozhen Yang, Mengxi Chen, Xinyuan Yao, Jiao Wang, Jiajia Shi, Yuanyuan Wang, Jinmin Tian, Xiangtian Zhou, Jia Qu, Sen Zhang
Summary: This study investigated the predictive role of choroidal blood perfusion (ChBP) and choroidal thickness (ChT) on myopia development in guinea pigs. Optical Coherence Tomography Angiography (OCTA) was used to assess the baseline ChBP and ChT. Myopia was induced for one week using formdeprivation (FD) or negative lenses. Correlations were found between the baseline choroidal values and the magnitude of myopia induced, as well as the changes in ChT and ChBP after myopia induction. The results suggest that baseline ChBP and ChT may be viable predictors of myopia development in guinea pigs.
EXPERIMENTAL EYE RESEARCH
(2023)