Article
Genetics & Heredity
Shu Yan, Ji Hu, Jia Li, Pengchao Wang, Yilong Wang, Zhaohui Wang
Summary: PRMT4 is upregulated in ischemic muscles and promotes angiogenesis. It regulates VEGF expression by interacting with YB1. Knockdown of YB1 attenuates PRMT4-mediated angiogenic effects in vitro.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Cardiac & Cardiovascular Systems
Xiaolei Liu, Guillermo Oliver
Summary: In recent years, the lymphatic system has gained increasing attention for its novel functional roles in health and disease. The lymphatic vasculature plays important roles in tissue-fluid balance, the immune response, and lipid absorption. Recent studies have discovered new and unexpected functional roles of the lymphatic vasculature in normal and pathological conditions, particularly in cardiac development and diseases. This review explores these novel roles and the potential therapeutic applications of targeting lymphatics for cardiovascular diseases.
CIRCULATION RESEARCH
(2023)
Article
Integrative & Complementary Medicine
Ruiying Liu, Ying Zheng, Tao Han, Jie Lan, Laixi He, Jianyou Shi
Summary: This study indicates that PF, an active compound from Traditional Chinese Medicine, has angiogenic effects by promoting proliferation, migration, and tube formation in BM-EPCs, and reducing cerebral infarction while increasing pro-angiogenic factors and vascular density in an ischemic stroke rat model. Up-regulation of VEGF/VEGF-R-2 may be the underlying mechanism of PF's angiogenic action.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Victoria A. Khotina, Andrey V. Omelchenko, Vladislav A. Kalmykov, Alexander N. Orekhov
Summary: The VEGF family plays a crucial role in the development of atherosclerosis and related cardiovascular diseases, and has the potential to be targeted for treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Ping Wu, Zan Tong, Lihua Luo, Yanan Zhao, Feixiang Chen, Yinping Li, Celine Huselstein, Qifa Ye, Qingsong Ye, Yun Chen
Summary: The combination of VEGF and Schwann cells in peripheral nerve repair shows promising results in promoting nerve regeneration. The HSPS conduits loaded with VEGF-A overexpressing Schwann cells demonstrate high durability and efficiency in repairing nerve tissue, making them a potential new avenue for nerve tissue engineering.
BIOACTIVE MATERIALS
(2021)
Article
Oncology
Yunlong Yang, Yihai Cao
Summary: Metastasis, the leading cause of cancer-associated mortality, is still poorly understood. Both blood and lymphatic vasculatures play crucial roles in distal metastasis, with VEGF being a key angiogenic factor. Anti-VEGF drugs have been widely used in clinical treatment of various cancers, but their impact on cancer metastasis and systemic disease is largely unknown.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Cell Biology
Sarah Saxena, Veronique Kruys, Raf De Jongh, Joseph Vamecq, Mervyn Maze
Summary: Aseptic surgical trauma induces the release of HMGB1, triggering the immune response and resulting in postoperative cognitive decline.
Review
Cell Biology
Yue-Yue Song, Dan Liang, De-Kun Liu, Lin Lin, Lei Zhang, Wen-Qing Yang
Summary: The main treatment strategy for ischemic diseases involves repairing vascular damage and encouraging angiogenesis by regulating the ERK signaling pathway. The mechanism by which ERK alleviates the ischemic state is not fully understood, but significant evidence suggests its critical role in the occurrence and development of ischemic diseases. The prospect of developing drugs that specifically act on the ERK pathway to promote angiogenesis in the treatment of ischemic diseases is promising.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sunhong Moon, Mi-Sook Chang, Seong-Ho Koh, Yoon Kyung Choi
Summary: This review discusses the partial repair of functional neural circuits in the central nervous system after an ischemic stroke, as well as the potential of stem cells and gaseous molecules in neuroprotection and regeneration. Shared molecular mechanisms involving the vascular endothelial growth factor (VEGF) and related factors play a role in therapeutic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Jingxuan Han, Lailiu Luo, Yicheng Wang, Shourong Wu, Vivi Kasim
Summary: This article highlights the recent advances in salidroside in treating ischemic diseases and discusses its pharmacological functions and underlying molecular mechanisms.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
William Lory, Bridgette Wellslager, Chao Sun, Ozlem Yilmaz, Hong Yu
Summary: S1PR2 antagonist JTE013 enhances expression of VEGFA, PDGFA, and GDF15 genes, activates TGFβ/Smad and Akt signaling, and promotes angiogenesis and alveolar bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ajmal Ahmad, Mohd Imtiaz Nawaz
Summary: This review article summarizes the significant scientific contributions made in the past seven decades regarding the implications of vascular endothelial-derived growth factor (VEGF) in angiogenesis processes. It highlights the role of VEGF in pathological conditions and its potential as a therapeutic target for managing cancers and intraocular neovascular disorders. The article also emphasizes the need for further research and development of alternative strategies in the management of VEGF-mediated pathological angiogenesis. Additionally, it discusses the emerging field of therapeutic angiogenesis for the treatment of ischemic disorders.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Adrian Moure, Guillermo Vilanova, Hector Gomez
Summary: This study investigates the complex interactions between interstitial flow and the affinity for matrix binding of different chemokine isoforms using a computational model. The results demonstrate that changing the matrix affinity of the chemokine isoform can invert the effect of interstitial flow on angiogenesis. These findings provide insight into the intricate mechanisms of angiogenesis in the tumor microenvironment.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Article
Endocrinology & Metabolism
Andrew M. N. Walker, Nele Warmke, Ben Mercer, Nicole T. Watt, Romana Mughal, Jessica Smith, Stacey Galloway, Natalie J. Haywood, Taha Soomro, Kathryn J. Griffin, Stephen B. Wheatcroft, Nadira Y. Yuldasheva, David J. Beech, Peter Carmeliet, Mark T. Kearney, Richard M. Cubbon
Summary: Endothelial insulin receptors play a crucial role in promoting angiogenesis and functional response to vascular endothelial growth factor A (VEGF-A). Deficiency of Insr can impair the response to VEGF-A, affecting the angiogenic process.
Article
Medicine, General & Internal
Giada Bianchetti, Luca Viti, Andrea Scupola, Mauro Di Leo, Linda Tartaglione, Andrea Flex, Marco De Spirito, Dario Pitocco, Giuseppe Maulucci
Summary: The study suggests that altered erythrocyte membrane fluidity in T1DM patients may serve as a marker for retinopathy, potentially resulting from various factors such as nonenzymatic glycosylation of proteins, oxidative stress, and lipid peroxidation.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Geriatrics & Gerontology
Marcello Covino, Giuseppe De Matteis, Maria Livia Burzo, Andrea Russo, Evelina Forte, Annamaria Carnicelli, Andrea Piccioni, Benedetta Simeoni, Antonio Gasbarrini, Francesco Franceschi, Claudio Sandroni
Summary: The study compared several COVID-19 scoring systems for predicting in-hospital death in older patients, with ISARIC-4C and COVID-GRAM showing the best performance at ED admission. NEWS, a widely validated score in clinical practice, also had similar efficacy in predicting outcomes for older COVID-19 patients.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Review
Biochemistry & Molecular Biology
Federico Biscetti, Elisabetta Nardella, Maria Margherita Rando, Andrea Leonardo Cecchini, Antonio Gasbarrini, Massimo Massetti, Andrea Flex
Summary: PAD is a manifestation of atherosclerosis affecting lower extremity arteries. CLTI, the most dangerous complication, often leads to limb loss without revascularization. EVT has become the primary approach for CLTI, but unsolved issues exist due to different clinical outcomes among patients with similar comorbidities undergoing the same procedure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Correction
Cardiac & Cardiovascular Systems
Federico Biscetti, Giovanni Tinelli, Maria Margherita Rando, Elisabetta Nardella, Andrea Leonardo Cecchini, Flavia Angelini, Giuseppe Straface, Marco Filipponi, Vincenzo Arena, Dario Pitocco, Antonio Gasbarrini, Massimo Massetti, Andrea Flex
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Federico Biscetti, Giovanni Tinelli, Maria Margherita Rando, Elisabetta Nardella, Andrea Leonardo Cecchini, Flavia Angelini, Giuseppe Straface, Marco Filipponi, Vincenzo Arena, Dario Pitocco, Antonio Gasbarrini, Massimo Massetti, Andrea Flex
Summary: The study found that HMGB1 is an independent risk factor for carotid plaque vulnerability in diabetic patients, with higher levels of HMGB1 and inflammatory cytokines in ICAS patients compared to WICAS patients. Among ICAS patients, those with unstable plaque had even higher levels of these cytokines. HMGB1 and osteoprotegerin were independently associated with unstable plaque in ICAS patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Alessandro Maino, Enrico Di Stasio, Maria Chiara Grimaldi, Luigi Cappannoli, Erica Rocco, Rocco Vergallo, Federico Biscetti, Silvia Baroni, Andrea Urbani, Raffaele Landolfi, Luigi Marzio Biasucci
Summary: This study found that 16% of COVID-19 patients had myocardial injury, with older patients with more cardiovascular comorbidities and higher inflammatory markers being more likely to experience cardiac injury. Patients with myocardial injury had significantly higher rates of hospitalization and mortality, with Hs-TnI testing able to predict disease severity and patient risk.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Tommaso Dionisi, Luisa Sestito, Claudia Tarli, Mariangela Antonelli, Alberto Tosoni, Stefano D'Addio, Antonio Mirijello, Gabriele Angelo Vassallo, Lorenzo Leggio, Antonio Gasbarrini, Giovanni Addolorato
Summary: The COVID-19 pandemic is causing stress and potential burnout for many physicians. A single-site survey in Italy found that medical specialty and clinical position could be risk factors for burnout development in a COVID team, with physicians board-certified in internal medicine showing lower risk of developing Emotional Exhaustion during the study.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Letter
Medicine, General & Internal
Maurizio Gabrielli, Giulia Pignataro, Marcello Candelli, Marta Sacco Fernandez, Martina Bizzarri, Alessandra Esperide, Francesco Franceschi
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Cell Biology
Silvia Giovannini, Federico Biscetti, Fabrizio Brau, Lorenzo Biscotti, Angelo Santoliquido, Dario Pitocco, Roberto Bernabei, Andrea Flex
Summary: The ratio of sortilin to omentin-1 may be a predictive factor for peripheral artery disease (PAD) in patients with type-2 diabetes, and it may be a promising marker for clinically significant atherosclerosis of the lower limbs.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Review
Biochemistry & Molecular Biology
Enrica Rossini, Federico Biscetti, Maria Margherita Rando, Elisabetta Nardella, Andrea Leonardo Cecchini, Maria Anna Nicolazzi, Marcello Covino, Antonio Gasbarrini, Massimo Massetti, Andrea Flex
Summary: Atherosclerotic cardiovascular disease remains a leading cause of morbidity and mortality in high-income countries, although its impact is decreasing. Statins are effective in reducing LDL cholesterol and the risk of mortality, but are under-prescribed or under-dosed due to concerns about side effects. Personalized treatment decisions should be made based on individual considerations and shared decision-making.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Andrea Leonardo Cecchini, Federico Biscetti, Maria Margherita Rando, Elisabetta Nardella, Giovanni Pecorini, Luis H. Eraso, Paul J. Dimuzio, Antonio Gasbarrini, Massimo Massetti, Andrea Flex
Summary: This article discusses the interplay between nutrition and the development/progression of PAD, summarizing the current research on dietary risk factors and their impact on PAD. It also explores the effects of dietary patterns and eating disorders on PAD and its complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Giuseppe De Matteis, Federico Biscetti, Davide Antonio Della Polla, Amato Serra, Maria Livia Burzo, Mariella Fuorlo, Maria Anna Nicolazzi, Angela Novelli, Angelo Santoliquido, Giovanni Gambassi, Antonio Gasbarrini, Andrea Flex, Francesco Franceschi, Marcello Covino
Summary: This study aimed to describe sex-based differences in clinical characteristics and outcomes among hospitalized patients affected by peripheral arterial disease (PAD). The study found that although there were some differences between sexes among PAD patients, gender did not significantly affect the occurrence of major adverse cardiovascular events (MACEs) and major adverse limb events (MALEs). However, among these patients, males were more likely to experience adverse clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Andrea Leonardo Cecchini, Federico Biscetti, Matteo Manzato, Lorenzo Lo Sasso, Maria Margherita Rando, Maria Anna Nicolazzi, Enrica Rossini, Luis H. Eraso, Paul J. Dimuzio, Massimo Massetti, Antonio Gasbarrini, Andrea Flex
Summary: This paper provides a literature review on pharmacotherapy for peripheral artery disease (PAD), focusing on the effects of different drug classes on inflammatory pathways. The study found that current treatments have anti-inflammatory properties that can potentially delay or prevent progression of PAD and improve outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Peripheral Vascular Disease
Federico Biscetti, Andrea Leonardo Cecchini, Maria Margherita Rando, Elisabetta Nardella, Antonio Gasbarrini, Massimo Massetti, Andrea Flex
Summary: This study reviewed the main risk factors of major adverse limb events in peripheral artery disease among diabetic patients, aiming to propose a new predictive tool to prevent disabling vascular complications of the disease.
ATHEROSCLEROSIS PLUS
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Alessandro Maino, Enrico Di Stasio, Maria Chiara Grimaldi, Cappannoli Luigi, Rocco Erica, Biscetti Federico, Landolfi Raffaele, Luigi Biasucci
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)