Article
Oncology
Jingbo Yu, Betty K. Hamilton, James Turnbull, Susan K. Stewart, Alla Vernaya, Valkal Bhatt, Oren Meyers, John Galvin
Summary: This study investigated the symptom burden and impact on activities of daily living (ADL) in patients with chronic GVHD. The results showed a high symptom burden and significant interference with physical function and ADL in patients with chronic GVHD.
Article
Gastroenterology & Hepatology
John E. Pandolfino, Dustin A. Carlson, Josie McGarva, Peter J. Kahrilas, Michael Vaezi, David Katzka, Tiffany H. Taft
Summary: The study developed a new Achalasia Patient-Reported Outcomes (APRO) Questionnaire, identified three subscales through investigation of patients with normal motility and achalasia, and found that symptom anxiety and hypervigilance moderate the relationship between APRO and quality of life.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Ethan Basch, Deborah Schrag, Sydney Henson, Jennifer Jansen, Brenda Ginos, Angela M. Stover, Philip Carr, Patricia A. Spears, Mattias Jonsson, Allison M. Deal, Antonia Bennett, Gita Thanarajasingam, Lauren J. Rogak, Bryce B. Reeve, Claire Snyder, Deborah Bruner, David Cella, Lisa A. Kottschade, Jane Perlmutter, Cindy Geoghegan, Cleo A. Samuel-Ryals, Barbara Given, Gina L. Mazza, Robert Miller, Jon F. Strasser, Dylan M. Zylla, Anna Weiss, Victoria S. Blinder, Amylou C. Dueck
Summary: The use of electronic PRO surveys to monitor symptoms in cancer patients led to statistically significant improvements in physical function, symptom control, and HRQOL at 3 months compared to usual care, with mean improvements of approximately 2.5 points on a 0-100 point scale.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Adrienne H. Kovacs, Gerald Lebovic, Stavroula Raptis, Samuel Blais, Christopher A. Caldarone, Nagib Dahdah, Frederic Dallaire, Christian Drolet, Jasmine Grewal, Camille L. Hancock Friesen, Edward Hickey, Gauri Rani Karur, Paul Khairy, Benedetta Leonardi, Michelle Keir, Brian W. McCrindle, Syed Najaf Nadeem, Ming-Yen Ng, Ashish H. Shah, Edythe B. Tham, Judith Therrien, Andrew E. Warren, Isabelle F. Vonder Muhll, Alexander Van de Bruaene, Kenichiro Yamamura, Michael E. Farkouh, Rachel M. Wald
Summary: This study explored the relationship between pulmonary regurgitation and quality of life and health status in adults with Tetralogy of Fallot (TOF), and found that with advancing age, patients reported more problems in mobility and pain or discomfort. Factors associated with superior patient-reported outcomes include race, syndrome, employment, and left ventricular function, while being asymptomatic was found to have the greatest impact on quality of life and health status.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Damien S. E. Broekharst, Sjaak Bloem, Edward A. G. Groenland, W. Fred van Raaij, Michel van Agthoven
Summary: Many people have attempted to develop burden of disease rankings for various purposes in healthcare. However, the rankings based on expert reports may differ from those based on patient reports. This study highlights the importance of developing and utilizing patient reported burden of disease rankings to establish a more comprehensive perspective on burden of disease.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Julie Hallet, Jesse Zuckerman, Matthew P. Guttman, Tyler R. Chesney, Barbara Haas, Alyson Mahar, Antoine Eskander, Wing C. Chan, Amy Hsu, Victoria Barabash, Natalie Coburn
Summary: Patient-reported symptom burden remains stable for up to 1 year after cancer surgery among older adults, with neither surgery nor adjuvant therapy coinciding with a worsening in symptom burden. However, the persistence of symptoms at 1 year may suggest gaps in supportive care for older adults.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Allergy
Hanna Bonnekoh, Jannis Jelden-Thurm, Monique Butze, Karoline Krause, Marcus Maurer, Pavel Kolkhir
Summary: Patients with UV, mostly female and of older age, experience significant impairment in quality of life due to long disease duration and high symptom burden. The main challenges reported by patients include low quality of life and the long-standing course of the disease. Quality of life is positively correlated with disease duration and number of clinical symptoms.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Oncology
Li Tang, Hongfan Yu, Wei Dai, Xiaojun Yang, Xing Wei, Xin Shelley Wang, Charles S. S. Cleeland, Qiang Li, Qiuling Shi
Summary: This study analyzed symptom trajectories after lung cancer surgery to understand patient heterogeneity and identify patients in need of extensive care.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Psychiatry
Ibrahim Turkoz, Larry Alphs, Jaskaran Singh, Carol Jamieson, Ella Daly, May Shawi, John J. Sheehan, Madhukar H. Trivedi, A. John Rush
Summary: Using the CGI-S scale, this study identified clinically meaningful and substantial changes in the MADRS, SDS, and PHQ-9 scores for patients with treatment-resistant depression. Clinically meaningful changes corresponded to 6-, 4-, and 3-point changes from baseline on the MADRS, SDS, and PHQ-9, while clinically substantial changes corresponded to 12-, 8-, and 6-point changes. The ESK plus OAD group showed a higher proportion of patients with substantial clinical improvement compared to the OAD plus PBO group after 28 days of treatment.
ACTA PSYCHIATRICA SCANDINAVICA
(2021)
Article
Oncology
Myung-Kyung Lee, Jihyun Oh
Summary: Exercise can have a synergistic effect on improving health-related quality of life (HRQOL) and depression in patients with gastric cancer, by indirectly positively affecting depression and directly influencing HRQOL.
Article
Cardiac & Cardiovascular Systems
Onkar Khullar, Aubriana Perez, Meredith Dixon, Jose N. Binongo, Manu S. Sancheti, Allan Pickens, Theresa Gillespie, Seth D. Force, Felix G. Fernandez
Summary: This study examined the success of routine patient-reported outcomes (PROs) assessment in an academic-based thoracic surgery practice. Results showed that out of 9725 thoracic surgery office visits, PROs data were obtained in 6899 visits from 3551 patients. The overall questionnaire completion rate was 65.7%, with a significant decline in April 2020. Rating: 8 out of 10.
ANNALS OF THORACIC SURGERY
(2023)
Article
Nursing
Yunhuan Li, Juejin Li, Xiaolin Hu
Summary: This study explored the effectiveness of ePRO-based symptom management interventions on cancer patients. The results showed that these interventions can improve symptom burden, quality of life, and overall survival. Targeted interventions for patients undergoing specific treatments were effective in relieving symptom burden and enhancing quality of life. The study suggests that integrating ePRO-based interventions into routine oncology care is beneficial.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2023)
Article
Oncology
Emily E. van Seventer, Madeleine G. Fish, Kathryn Fosbenner, Katie Kanter, Amirkasra Mojtahed, Jill N. Allen, Lawrence Blaszkowsky, Jeffrey W. Clark, Jon Dubois, Joseph W. Franses, Bruce J. Giantonio, Lipika Goyal, Samuel J. Klempner, Eric J. Roeland, David P. Ryan, Colin D. Weekes, Therese Mulvey, Areej El-Jawahri, Nora Horick, Ryan B. Corcoran, Aparna R. Parikh, Ryan D. Nipp
Summary: This study found that baseline patient-reported outcomes (PROs) are associated with treatment response, healthcare utilization, and survival in patients with advanced gastrointestinal cancer. Specifically, physical symptoms and functional quality of life were correlated with disease progression and survival.
Review
Dentistry, Oral Surgery & Medicine
Gotfredsen Klaus
Summary: Evidence-based dentistry involves using evidence from the literature, clinical expertise, and patient expectations to make decisions and assess treatment. Patient satisfaction can be evaluated using questionnaires or structured questions and includes affability, availability, and ability. Questionnaires such as the oral health impact profile (OHIP) or the dental impact on daily living (DIDL) can be used to assess patient perception and quality of life. Patient-reported outcome measures (PROMs) have shown to enhance patient engagement and should be integrated into clinical care.
PERIODONTOLOGY 2000
(2023)
Article
Surgery
S. R. Markar, V Sounderajah, A. Johar, G. Zaninotto, C. Castoro, P. Lagergren, J. A. Elliott, S. S. Gisbertz, C. Mariette, R. Alfieri, J. Huddy, E. Pinto, M. Scarpa, F. Klevebro, B. Sunde, C. F. Murphy, C. Greene, N. Ravi, G. Piessen, H. Brenkman, J. Ruurda, R. van Hillegersberg, S. M. Lagarde, B. P. Wijnhoven, M. Pera, J. Roigg, S. Castro, R. Matthijsen, J. Findlay, S. Antonowicz, N. Maynard, O. McCormack, A. Ariyarathenam, G. Sanders, E. Cheong, S. Jaunoo, W. Allum, J. van Lanschot, M. Nilsson, J. Reynolds, M. I. van Berge Henegouwen, G. B. Hanna
Summary: Long-term symptom burden is common after oesophageal cancer surgery, with symptoms clustering into six domains: lethargy, musculoskeletal pain, dumping, lower gastrointestinal symptoms, regurgitation/reflux, and swallowing problems. Factors associated with severe symptoms include surgical approach, neoadjuvant therapy, patient age, and sex.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Physics, Fluids & Plasmas
G. W. Bailey, O. V. Vilkhivskaya, M. R. Gilbert
Summary: Studies have shown that during operation of fusion reactors, steels will become activated and need to be disposed of as radioactive waste. The waste expectations of steels from European DEMO-like fusion reactors were investigated, revealing that some steels may struggle to meet low level waste requirements. It is recommended that waste disposal strategies are included in fusion reactor proposals before construction begins to align with radioactive waste regulations.
Article
Physics, Condensed Matter
Yichen Qian, Mark R. Gilbert, Lucile Dezerald, David Cereceda
Summary: Tungsten and tungsten alloys are considered as leading materials for future fusion energy devices due to their high melting point, thermal conductivity, and low radioactive footprint. However, the low fracture toughness of tungsten limits its applications. Significant neutron-induced transmutation occurs in tungsten components during nuclear fusion reactions, necessitating the use of density functional theory calculations to better understand their behavior.
JOURNAL OF PHYSICS-CONDENSED MATTER
(2021)
Review
Materials Science, Multidisciplinary
M. R. Gilbert, K. Arakawa, Z. Bergstrom, M. J. Caturla, S. L. Dudarev, F. Gao, A. M. Goryaeva, S. Y. Hu, X. Hu, R. J. Kurtz, A. Litnovsky, J. Marian, M-C Marinica, E. Martinez, E. A. Marquis, D. R. Mason, B. N. Nguyen, P. Olsson, Y. Osetskiy, D. Senor, W. Setyawan, M. P. Short, T. Suzudo, J. R. Trelewicz, T. Tsuru, G. S. Was, B. D. Wirth, L. Yang, Y. Zhang, S. J. Zinkle
Summary: Predicting material performance in fusion reactor environments relies on computational modeling supported by experiments. Leading experts discussed current positions and ongoing challenges in modeling fusion materials, highlighting topics such as irradiation-induced defect production, gas behavior, clustering, and defect evolution.
JOURNAL OF NUCLEAR MATERIALS
(2021)
Article
Oncology
Terri S. Armstrong, Mark R. Gilbert
Summary: Clinical research for patients with rare cancers is challenging due to difficulties in patient accrual, trial design, and evaluation of treatment outcomes. Despite these challenges, studies on rare cancers have yielded important findings, emphasizing the importance of incorporating patient outcomes measures in future trials.
Article
Physics, Fluids & Plasmas
L. W. Packer, P. Batistoni, N. Bekris, S. C. Bradnam, M. Fabbri, Z. Ghani, M. R. Gilbert, R. Kierepko, E. Laszynska, D. Leichtle, I. Lengar, S. Loreti, J. W. Mietelski, C. R. Nobs, M. Pillon, M. I. Savva, I. E. Stamatelatos, T. Vasilopoulou, A. Wojcik-Gargula, A. Zohar
Summary: The latest results from experimental activities conducted within the 'ACT' sub-project under the EUROfusion WPJET3 programme on irradiating ITER materials are presented, including analyses of various material samples and characterization of irradiation locations. These results also include comparisons with neutron transport and activation calculation predictions for the ITER samples.
Article
Physics, Fluids & Plasmas
Luca Reali, Max Boleininger, Mark R. Gilbert, Sergei L. Dudarev
Summary: In this study, we propose a method for computing macroscopic elastic stress and strain in components of a fusion power plant using the eigenstrain produced by defects in a material exposed to high energy neutron irradiation. Analytical and numerical analysis of several case studies related to the design of a fusion power plant show that the spatial distribution of defects leads to significant elastic stresses in ion-irradiated thin films, pressurized cylindrical tubes, and breeding blanket modules.
Article
Oncology
Guangyang Yu, Ying Pang, Mythili Merchant, Chimene Kesserwan, Vineela Gangalapudi, Abdalla Abdelmaksoud, Alice Ranjan, Olga Kim, Jun S. Wei, Hsien-Chao Chou, Xinyu Wen, Sivasish Sindiri, Young K. Song, Liqiang Xi, Rosandra N. Kaplan, Terri S. Armstrong, Mark R. Gilbert, Kenneth Aldape, Javed Khan, Jing Wu
Summary: The study found that TMB was not correlated with immune score in IDH-mutant gliomas, while in IDH-wildtype tumors, TMB was positively correlated with expressed neoantigens but inversely correlated with immune score. The Antigen Processing and Presentation (APP) score may have potential as a biomarker for immune therapy response in gliomas.
Article
Physics, Fluids & Plasmas
Sehila M. Gonzalez de Vicente, Nicholas A. Smith, Laila El-Guebaly, Sergio Ciattaglia, Luigi Di Pace, Mark Gilbert, Robert Mandoki, Sandrine Rosanvallon, Youji Someya, Kenji Tobita, David Torcy
Summary: In the absence of official standards and guidelines, fusion designers have adopted well-established standards for fission-based nuclear power plants. However, this approach may result in overconservative measures and increased cost and complexity. One important issue in fusion power is the generation of radioactive waste, which is significantly different from fission NPP waste. Fusion waste mainly consists of low-level and intermediate level waste, but without many long-lived isotopes. The use of reduced-activation materials in fusion technology allows for lower decay heat removal and rapid radioactivity decay.
Review
Energy & Fuels
Arunodaya Bhattacharya, Steven J. Zinkle, Jean Henry, Samara M. Levine, Philip D. Edmondson, Mark R. Gilbert, Hiroyasu Tanigawa, Charles E. Kessel
Summary: RAFM and ODS steels are the most promising candidates for fusion first-wall/blanket structures, but their performance will deteriorate due to neutron damage and gas effects during operation. Future development should target materials with lower chromium concentration to minimize irradiation-induced effects.
JOURNAL OF PHYSICS-ENERGY
(2022)
Article
Oncology
Sarah Jenkins, Wei Zhang, Seth M. Steinberg, Darryl Nousome, Nicole Houston, Xiaolin Wu, Terri S. Armstrong, Eric Burton, Dee Dee Smart, Ritu Shah, Cody J. Peer, Brett Mozarsky, Oluwatobi Arisa, William D. Figg, Tito R. Mendoza, Elizabeth Vera, Priscilla Brastianos, Scott Carter, Mark R. Gilbert, Carey K. Anders, Roisin M. Connolly, Carol Tweed, Karen L. Smith, Imran Khan, Stanley Lipkowitz, Patricia S. Steeg, Alexandra S. Zimmer
Summary: This study aimed to investigate the preventive effect of low-dose temozolomide (TMZ) combined with T-DM1 on brain metastases in HER2-negative and HER2-positive breast cancer. The results showed that the combination of TMZ and T-DM1 had low-grade toxicity and potential therapeutic activity in preventing brain metastases in patients with HER2-negative and HER2-positive breast cancer.
CLINICAL CANCER RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Shu Huang, Ryan Kerr, Samuel Murphy, Mark R. Gilbert, Jaime Marian
Summary: A numerical model is presented to predict oxide scale growth on tungsten surfaces under exposure to oxygen at high temperatures, with simulations showing deviations from classical parabolic growth in certain cases. The model is parameterized using experimental measurements and electronic structure calculations, with a comparison to extensive experimental data showing reasonable agreement at most temperatures. This work attempts to embed the thermodynamic and kinetic complexity of tungsten oxide growth into a comprehensive mesoscale kinetic model to fill existing knowledge gaps and guide future tungsten oxidation models.
MODELLING AND SIMULATION IN MATERIALS SCIENCE AND ENGINEERING
(2022)
Review
Oncology
Kayla N. N. Roche, Diane Cooper, Terri S. S. Armstrong, Amanda L. L. King
Summary: Research shows that solid tumor patients experience high levels of psychological distress at diagnosis, but little is known about how this symptom affects disease outcomes. This systematic review explores the link between distress and survival in solid tumor patients, suggesting that psychological distress may impact disease-related outcomes, including survival.
Article
Nuclear Science & Technology
Sophia O. von Tiedemann, David M. Collins, Mark R. Gilbert, Ivan A. Kodeli
Summary: Predictions of material activity in commercial fusion conditions mostly rely on computational methods due to lack of data on long-term effects of high-energy neutron irradiation on structural steels. This study focused on modelling neutron activation of four structural steels in a fusion reactor environment after 20 years of operation. Eurofer and F82H steels exhibited higher resistance to neutron activation than G91 and SS316L(N)-IG. The vacuum vessel (SS316L(N)-IG) would not be classified as low-level waste for several centuries.
FUSION ENGINEERING AND DESIGN
(2023)
Article
Oncology
Yeonju Kim, Terri S. Armstrong, Mark R. Gilbert, Orieta Celiku
Summary: Limitations in trial design, accrual, and data reporting hinder efficient and reliable drug evaluation in cancer clinical trials. A semi-automated survey of adult interventional neuro-oncology trials revealed suboptimal trial designs with low randomization rates and overestimation of effect size. Limited results reporting calls for incentives to improve data reporting and harmonization.
Article
Oncology
Yeonju Kim, Terri S. Armstrong, Mark R. Gilbert, Orieta Celiku
NEURO-ONCOLOGY ADVANCES
(2022)
