Journal
CURRENT TREATMENT OPTIONS IN ONCOLOGY
Volume 13, Issue 1, Pages 58-70Publisher
SPRINGER
DOI: 10.1007/s11864-011-0174-0
Keywords
Salivary gland neoplasm; Salivary gland cancer; Salivary gland tumor; Salivary gland surgery; Recurrent salivary gland cancer; Recurrent salivary gland neoplasm
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Salivary gland cancer is the most diverse cancer in the body consisting of up to 24 different pathologic subtypes. Although these cancers arise within a common group of glands in the head and neck region, these diverse cancers differ substantially in clinical behavior. As a result, salivary cancers are often categorized as low, intermediate, or high-risk for recurrence and metastasis based on histopathologic subtype and tumor stage. Appropriate risk classification of a given salivary tumor provides a useful guide to the physicians who determine the appropriate treatment regimen. Low-risk tumors can be treated successfully with surgery alone, whereas intermediate and high-risk tumors often require multimodality therapy. Recurrent salivary cancer should be considered high-risk by definition, especially if previously treated with appropriate therapy, and therefore requires aggressive multimodality therapy in order to achieve adequate local control and disease-free survival.
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