Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 12, Issue 21, Pages 2314-2323Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156802612805289845
Keywords
schizophrenia; neuroimaging; membrane; phospholipase A(2); dopamine
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Physiological enzymatic cleavage of membrane phospholipids by phospholipase A(2) (PLA(2)) results in normal levels of phosphomonoester and phosphodiester, by which a normal dopamine neurotransmission is maintained. Data from postmortem tissue and in vivo imaging studies suggest that increased activity of intracellular calcium-independent PLA(2) (iPLA(2)) in the brain of schizophrenic patients might accelerate the breakdown of membrane phospholipids and alter the properties of neuronal membranes, which in turn contributes to a hypodopaminergy. Alterations in PLA(2) activity are probably genetically determined and represent a possible pharmacological target for Schizophrenia.
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