Article
Materials Science, Multidisciplinary
Harshavardhan Budharaju, Shruthy Suresh, Muthu Parkkavi Sekar, Brigita De Vega, Swaminathan Sethuraman, Dhakshinamoorthy Sundaramurthi, Deepak M. Kalaskar
Summary: Ceramic bone implants have potential properties ideal for long-term implantation applications, and they have advantages including biocompatibility, low cost, and the ability to be made into various shapes. Bone transplantation is the second largest transplantation surgery globally, indicating hope for potential treatment options for bone diseases.
MATERIALS & DESIGN
(2023)
Article
Engineering, Manufacturing
Quyang Liu, Tian Li, Soo Wah Gan, Soon Yee Chang, Ching Chiuan Yen, Wei Zhai
Summary: In this study, hierarchical porous hydroxyapatite (hpHA) scaffolds with high porosity and superior mechanical properties were fabricated using 3D printing of emulsion inks. The scaffolds exhibited improved cell attachment and proliferation, indicating their potential for bone tissue engineering applications. The reported method of 3D printing emulsion inks is a promising strategy for the fabrication of highly porous scaffolds.
ADDITIVE MANUFACTURING
(2023)
Review
Engineering, Biomedical
Chaoqian Zhao, Weiye Liu, Min Zhu, Chengtie Wu, Yufang Zhu
Summary: Bioceramic-based scaffolds play a crucial role in bone defect repair and antibacterial function. Various antibacterial strategies have been developed for these scaffolds, leading to significant advancements in the field.
BIOACTIVE MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Maria Grazia Tupone, Michele d'Angelo, Vanessa Castelli, Mariano Catanesi, Elisabetta Benedetti, Annamaria Cimini
Summary: Exploring and developing multifunctional intelligent biomaterials is crucial for improving next-generation therapies in tissue engineering and regenerative medicine. These biomaterials can mimic the in situ microenvironment and provide specialized bioactive signals to regulate the surrounding biological habitat, contributing to wound healing and biomaterial integration. The connection between stem cells and biomaterials can stimulate specific modifications in cell properties and fate, influencing processes such as self-renewal, adhesion, and differentiation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biology
Ahmad Taha Khalaf, Yuanyuan Wei, Jun Wan, Jiang Zhu, Yu Peng, Samiah Yasmin Abdul Kadir, Jamaludin Zainol, Zahraa Oglah, Lijia Cheng, Zheng Shi
Summary: Trauma and bone loss pose significant challenges in orthopedic, craniofacial, and plastic surgeries. The combination of 3D-printed bone tissue engineering scaffolds with stem cells has shown promising results. Bioceramic scaffolds are a promising solution. Advancements in 3D printing technology allow for the simulation of mechanical and biological properties of bone tissue and the printing of complex structures. This article reviews the current methods in orthopedic bioprinting technology and discusses the challenges and prospects in this field.
Article
Engineering, Biomedical
Miaoda Shen, Yifan Li, Fengling Lu, Yahui Gou, Cheng Zhong, Shukun He, Chenchen Zhao, Guojing Yang, Lei Zhang, Xianyan Yang, Zhongru Gou, Sanzhong Xu
Summary: This study fabricates a series of Mg-doped wollastonite scaffolds with fully interconnected pore networks and curved pore architectures called triply periodic minimal surfaces (TPMS) using a digital light processing technique. The diamond and gyroid pore structures exhibit higher initial compressive strength and faster Mg-ion-release rate, but delay the regeneration of bone tissue in vivo. The design methods in this study provide an important perspective for optimizing the pore architecture design of bioceramic scaffolds to accelerate the rate of osteogenesis and promote clinical translation.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Hossein Jodati, Zafer Evis, Aysen Tezcaner, Ammar Z. Alshemary, Ali Motameni
Summary: Composite scaffolds made of boron-doped hydroxyapatite and baghdadite were successfully prepared. The incorporation of baghdadite increased scaffold porosity, surface area, and micropore volumes. The composite scaffolds exhibited higher degradation rates, enhanced cell proliferation, and greater osteogenic differentiation compared to the boron-doped hydroxyapatite scaffolds. Despite being slightly weaker, the compressive strengths of the composite scaffolds were higher than other baghdadite-based composite scaffolds reported in the literature. Overall, the novel composite scaffolds combined the advantages of both components and advanced the development of ideal scaffolds for bone tissue engineering.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Environmental
Lina Wu, Xuan Pei, Boqing Zhang, Zixuan Su, Xingyu Gui, Canyu Gao, Likun Guo, Hongyuan Fan, Qing Jiang, Li Zhao, Changchun Zhou, Yujiang Fan, Xingdong Zhang
Summary: In this study, personalized porous bone tissue engineering scaffolds were fabricated by 3D printing, and functionalized nanorod morphologies were controllably fabricated. The influence of nanorods geometrical cues on cellular behaviors and the mechanics of triggered osteogenesis were studied. The results provided evidence that the surface nano-scale morphology triggered signals for promoting osteogenic differentiation. In vivo experiments showed that the 3D printed scaffolds with a nanorod coating promoted bone regeneration.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Biotechnology & Applied Microbiology
Zahra Yazdanpanah, James D. Johnston, David M. L. Cooper, Xiongbiao Chen
Summary: Treating large bone defects is challenging and bone tissue engineering using 3D bioprinted scaffolds has emerged as a promising approach. This review highlights the latest developments in the use of bioprinted scaffolds for critical-sized defect treatment, including the biomaterials, cells, and growth factors used in bioink formulation and bioprinting techniques. The review also discusses current limitations and emerging approaches in this field.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Engineering, Biomedical
Tejas M. Koushik, Catherine M. Miller, Elsa Antunes
Summary: Bone tissue engineering has become a well-known field of study in the past decade, with advancements in materials, processing techniques, and understanding of bone healing pathways. Synthetic scaffolds face the challenge of providing load-bearing capability and interaction with the local extracellular matrix for promoting bone healing. This article discusses the usage and processing of multi-materials and hierarchical structures to mimic the structure of natural bone tissues for bioactive and load-bearing synthetic scaffolds.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Xin Wang, Yin Liu, Meng Zhang, Dong Zhai, Yufeng Wang, Hui Zhuang, Bing Ma, Yu Qu, Xiaopeng Yu, Jingge Ma, Hongshi Ma, Qingqiang Yao, Chengtie Wu
Summary: The study introduces a new strategy of introducing defects to improve the biological performance of bioceramic scaffolds, which shows advantages in degradation rate and osteogenic capacity over traditional scaffolds. The defect-rich black akermanite (B-AKT) bioceramic scaffolds stimulate osteogenic differentiation of rabbit bone mesenchymal stem cells and promote bone formation in vivo, as well as exhibit excellent photothermal and antitumor effects under near infrared irradiation.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Amir Mohammad Maadani, Erfan Salahinejad
Summary: Bioceramics, particularly calcium phosphates, bioactive glasses, and crystalline silicates, are widely used biomaterials for tissue regeneration and therapeutic delivery. Polymeric coatings, such as polylactic acid (PLA) and poly(lactic-co-glycolic acid) (PLGA), have been extensively researched for enhancing the properties of ceramic tissue engineering scaffolds. Both PLA and PLGA can improve the mechanical behaviors of the scaffolds, but PLA has a greater influence on their biodegradability, bioactivity, and delivery kinetics. However, the biocompatibility response to this surface treatment is dependent on the specific conditions and needs further experimentation for accurate determination.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Materials Science, Biomaterials
Mahendran Thangavel, Renold Elsen Selvam
Summary: This review focuses on the advancements in additive manufacturing techniques for fabricating bioceramic scaffolds and their characterizations leading to bone tissue regeneration. The most commonly used scaffold materials are calcium phosphate apatite materials. Functionally graded scaffolds are fabricated by utilizing the right choice of 3D printing method and material combinations. The biomechanical loading conditions and finite element analysis (FEA) technique are discussed in relation to the scaffold design and mechanical property investigation.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Review
Engineering, Biomedical
Guanyin Zhu, Tianxu Zhang, Miao Chen, Ke Yao, Xinqi Huang, Bo Zhang, Yazhen Li, Jun Liu, Yunbing Wang, Zhihe Zhao
Summary: Bone-tissue defects are a global issue, with autologous and allogeneic bone grafting failing to achieve ideal therapeutic effects. This has led researchers to explore novel bone-regeneration methods, with the development of BTE scaffolds at the forefront. By delving into bone physiology and healing mechanisms, biomimicking and bioinspired BTE scaffolds are making progress.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
Zhihong Dong, Jiabao Gong, Haowei Zhang, Yanting Ni, Lijia Cheng, Qiaoyu Song, Lu Tang, Fei Xing, Ming Liu, Changchun Zhou
Summary: A layered perforated 45S5 bioglass scaffold was designed and fabricated using 3D printing technology, and its mechanical properties and porosity were analyzed. The results showed that the scaffold exhibited good mechanical properties and porosity, making it a potential candidate for bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2022)
Article
Medicine, Research & Experimental
Joseph J. Pearson, Alexandra S. Ortiz, Sergio Montelongo, C. Blake Simpson, Teja Guda, Gregory R. Dion
Article
Medicine, Research & Experimental
Gregory R. Dion, Teja Guda, Shigeyuki Mukudai, Renjie Bing, Jean-Francois Lavoie, Ryan C. Branski
Article
Cell & Tissue Engineering
Ramon E. Coronado, Maria Somaraki-Cormier, Joo L. Ong, Glenn A. Halff
STEM CELL RESEARCH
(2019)
Article
Engineering, Biomedical
Solaleh Miar, Cynthia A. Perez, Joo L. Ong, Teja Guda
JOURNAL OF BIOMATERIALS APPLICATIONS
(2019)
Article
Engineering, Biomedical
Prabaha Sikder, Sarit B. Bhaduri, Joo L. Ong, Teja Guda
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2020)
Article
Engineering, Biomedical
Joseph J. Pearson, Nicholas Gerken, Chunsik Bae, Kyu-Bok Lee, Arpan Satsangi, Sean McBride, Mark R. Appleford, David D. Dean, Jeffrey O. Hollinger, Joo L. Ong, Teja Guda
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2020)
Article
Cell & Tissue Engineering
Patricia Carlisle, Jeffrey Marrs, Laura Gaviria, David T. Silliman, John F. Decker, Pamela Brown Baer, Teja Guda
TISSUE ENGINEERING PART C-METHODS
(2019)
Article
Dentistry, Oral Surgery & Medicine
David L. Cochran, Archie Jones, Ryushiro Sugita, Michael C. Brown, Teja Guda, Hari Prasad, Joo L. Ong, Alan Pollack, George W. Kay
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
(2020)
Article
Cell & Tissue Engineering
Gennifer Chiou, Elysa Jui, Allison C. Rhea, Aparna Gorthi, Solaleh Miar, Francisca M. Acosta, Cynthia Perez, Yasir Suhail, Kshitiz, Yidong Chen, Joo L. Ong, Rena Bizios, Christopher Rathbone, Teja Guda
CELLULAR AND MOLECULAR BIOENGINEERING
(2020)
Article
Computer Science, Information Systems
Nafiseh Ebrahimi, Teja Guda, Miltiadis Alamaniotis, Dimitrios Miserlis, Amir Jafari
Article
Business
Gianluca Zanella, Dante B. Castro Solano, Cory R. A. Hallam, Teja Guda
INTERNATIONAL JOURNAL OF ENTREPRENEURIAL BEHAVIOR & RESEARCH
(2019)
Article
Dentistry, Oral Surgery & Medicine
Patricia L. Carlisle, Teja Guda, David T. Silliman, Robert G. Hale, Pamela R. Brown Baer
JOURNAL OF THE KOREAN ASSOCIATION OF ORAL AND MAXILLOFACIAL SURGEONS
(2019)
Article
Cell & Tissue Engineering
Liang Ma, Rui Hua, Yi Tian, Hongyun Cheng, Roberto Jose Fajardo, Joseph J. Pearson, Teja Guda, Daniel Brian Shropshire, Sumin Gu, Jean X. Jiang
