Review
Psychiatry
Chelsea Jones, Jessica Harasym, Antonio Miguel-Cruz, Shannon Chisholm, Lorraine Smith-MacDonald, Suzette Bremault-Phillips
Summary: This study aimed to explore the evidence of NCATs use among military personnel with mTBIs, evaluating the psychometric properties of commonly used NCATs and identifying knowledge gaps for future research. The findings suggest that additional research is needed to validate the effectiveness and utility of NCATs in military populations, especially for those outside of the United States and individuals with other cognitive impairments.
JMIR MENTAL HEALTH
(2021)
Article
Clinical Neurology
Kasper Lolk, Julie W. Dreier, Jakob Christensen
Summary: The study found that the risk of epilepsy following traumatic brain injury increases with the repetition and severity of the injury, with females more likely to develop epilepsy after mild injuries and males more likely after severe injuries. These risks remain elevated for decades post-injury.
Article
Endocrinology & Metabolism
Matias Vaajala, Ilari Kuitunen, Rasmus Liukkonen, Ville Ponkilainen, Maiju Kekki, Ville M. M. Mattila
Summary: This study aims to investigate the association between traumatic brain injury (TBI) and the risk for the development of gestational diabetes (GDM). The results of a retrospective cohort study show that TBI is associated with an increased risk of GDM, with the highest risk observed at least 9 years after the injury.
ACTA DIABETOLOGICA
(2023)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Ann Scher, James S. McGinley, R. J. Wirth, Richard B. Lipton, Heidi Terrio, Lisa A. Brenner, Wesley R. Cole, Karen Schwab
Summary: The study found that post-traumatic headaches differ from other headaches in terms of symptom complexity, with post-traumatic headache patients more likely to seek medical care for headaches.
Article
Psychology, Multidisciplinary
Ashley N. Clausen, Heather C. Bouchard, Kathleen A. Welsh-Bohmer, Rajendra A. Morey
Summary: This study compared the chronic effects of combat-related blast mTBI and subconcussive blast exposure on neuropsychological performance in Veterans. Results showed that Veterans with combat-related blast mTBI exhibited significantly slower processing speed compared to controls, even after controlling for PTSD and depressive symptoms. However, there were no significant differences in cognition between subconcussive and control groups, or between subconcussive and combat-related blast mTBI groups, suggesting that neurocognitive assessment may not be sensitive enough to detect the long-term effects of subconcussive blast exposure.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Cell Biology
Ruslan Prus, Olena Appelhans, Maksim Logash, Petro Pokotylo, Grzegorz Jozef Nowicki, Barbara Slusarska
Summary: Traumatic brain injury is a serious issue in modern medicine, with our study showing that mild TBI causes different histological changes in the livers of adult and juvenile rats. The most significant changes were observed on days 5-7, with compensatory phenomena prevailing on days 14-21 in both groups.
Article
Immunology
Emer Ryan, Lynne Kelly, Catherine Stacey, Dean Huggard, Eimear Duff, Danielle McCollum, Ann Leonard, Gerard Boran, Dermot R. Doherty, Turlough Bolger, Eleanor J. Molloy
Summary: This study demonstrates altered cytokine profiles and endotoxin responses in children with traumatic brain injury (TBI), including mild TBI. Children with mild TBI showed decreased levels of IL-8, IL-10, IL-17A, and TNF-alpha compared to controls, along with increased levels of IFN-gamma. In severe TBI, there was no significant IL-6 response to endotoxin, but an increase in IL-17A. These findings suggest immune dysfunction following TBI, especially in mild cases.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Saef Izzy, Alexander Brown-Whalen, Taha Yahya, Aliyah Sarro-Schwartz, Gina Jin, Joon Yong Chung, Sevda Lule, Liza M. Morsett, Ali Alquraini, Limin Wu, Suzanne E. Hickman, Michael J. Whalen, Joseph El Khoury
Summary: The study found that repetitive closed head injury (rCHI) did not accelerate tau pathology and did not worsen behavioral outcomes in adolescent mice. However, rCHI induced microgliosis in the cortex and hippocampus and astrocytosis in the corpus callosum of P301S mice by 40 days post-injury. There were no significant microgliosis or astrocytosis observed in age-matched WT mice or sham-injured P301S mice after rCHI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Kalman Katlowitz, Shankar Gopinath, Jovany Cruz Navarro, Claudia Robertson
Summary: Traumatic brain injuries (TBIs) are highly damaging and often fatal. Medical management aims to minimize secondary neurological damage while promoting recovery. Statins, originally developed for managing cholesterol, have shown promise in TBI management due to their effects on inflammation and angiogenesis. However, more research is needed to fully understand their potential and establish proper treatment regimens.
Article
Clinical Neurology
Andrea L. C. Schneider, Carrie B. Peltz, Yixia Li, Amber Bahorik, Raquel C. Gardner, Kristine Yaffe
Summary: This study found that traumatic brain injury (TBI) is associated with long-term stroke risk, with differences observed in age, sex, race and ethnicity, and time since TBI diagnosis. The highest risk of stroke occurs in the first year after TBI diagnosis, but the risk remains elevated for more than 10 years. Both mild and moderate/severe/penetrating TBI increase the risk of stroke compared to individuals without TBI. Older individuals have a stronger association between TBI and stroke, while Black veterans have a weaker association compared to other races and ethnicities. These findings suggest that veterans with prior TBI should be targeted for primary stroke prevention measures.
Article
Health Care Sciences & Services
Jacinta Thorne, Shaun Markovic, HuiJun Chih, Elizabeth Thomas, Amanda Jefferson, Samar Aoun, Melinda Fitzgerald, Sarah Hellewell
Summary: This study investigates the types of healthcare sought by Australians following mild traumatic brain injury (mTBI) and explores factors and symptoms associated with healthcare choices. The study finds that a significant proportion of respondents did not seek any care after experiencing a concussion. Lower education level, previous mTBI or mental health issues were associated with a lower likelihood of seeking care, while experiencing loss of consciousness, amnesia, and other symptoms increased the likelihood of seeking care. Those who did not seek care were more likely to recover within one month.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Orthopedics
Robert C. Lynall, Christopher D'Lauro, Zachary Y. Kerr, Kristen Knight, Emily Kroshus, Daniel D. Leeds, Johna K. Register-Mihalik, Michael McCrea, Steven P. Broglio, Thomas McAllister, Julianne D. Schmidt
Summary: The study aimed to investigate the association between previous concussion diagnosis status and outcomes on standard baseline concussion assessments. The results showed that individuals with a history of undiagnosed concussions performed worse on baseline clinical indicators.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Clinical Neurology
Henry W. Mahncke, Joseph DeGutis, Harvey Levin, Mary R. Newsome, Morris D. Bell, Chad Grills, Louis M. French, Katherine W. Sullivan, Sarah-Jane Kim, Annika Rose, Catherine Stasio, Michael M. Merzenich
Summary: This study evaluated the efficacy of self-administered plasticity-based cognitive training for individuals with a history of mild traumatic brain injury and cognitive impairment. The treatment group showed significant improvement in cognitive function compared to the active control group, with equivalent results in depressive and cognitive symptoms between the two groups.
Article
Clinical Neurology
Josh W. Faulkner, Alice Theadom, Deborah L. Snell, Matt N. Williams
Summary: This study applied network analysis to investigate post-concussion symptoms after mild traumatic brain injury (mTBI) and found that frustration, blurred vision, and concentration difficulties were central symptoms in two different mTBI samples. These symptoms may play an influential role in the experience and maintenance of post-concussion symptoms.
FRONTIERS IN NEUROLOGY
(2023)
Article
Rehabilitation
Janet P. Niemeier, Jeffrey S. Kreutzer, Jennifer H. Marwitz, Adam P. Sima
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2019)
Article
Gastroenterology & Hepatology
Samarth S. Patel, Fei-Pi Lin, Viviana A. Rodriguez, Chandra Bhati, Binu V. John, Taylor Pence, Mohammad B. Siddiqui, Adam P. Sima, Antonio Abbate, Trevor Reichman, Mohammad S. Siddiqui
LIVER INTERNATIONAL
(2019)
Editorial Material
Rehabilitation
Blessen C. Eapen, David X. Cifu
PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA
(2019)
Article
Cardiac & Cardiovascular Systems
Michael P. O'Quinn, Kenneth J. Dormer, Jose F. Huizar, Kytai T. Nguyen, Karoly Kaszala, Adam Sima, Kenneth A. Ellenbogen, Alex Y. Tan
Article
Neurosciences
Kathryn Harrison, Yong Ung Kwon, Adam Sima, Bhushan Thakkar, Gregory Crosswell, Jacqueline Morgan, D. S. Blaise Williams
HUMAN MOVEMENT SCIENCE
(2019)
Article
Clinical Neurology
William McKinley, Adam Hills, Adam Sima
Summary: This study retrospectively reviewed the demographics, clinical characteristics, and functional outcomes of 9 patients with PCS treated in a SCI rehabilitation unit over the past five years. The most common etiology of PCS was spinal cord compression from tumors, with common complications including neuropathic pain, spasticity, and neurogenic bladder. During rehabilitation, significant improvements in functional independence were observed in these patients, with a majority being able to walk independently at discharge.
JOURNAL OF SPINAL CORD MEDICINE
(2021)
Article
Clinical Neurology
Randolph M. Jenkins, Nathaniel L. Manche, Adam P. Sima, Jennifer H. Marwitz, William C. Walker
JOURNAL OF HEAD TRAUMA REHABILITATION
(2020)
Article
Clinical Neurology
Jeffrey S. Kreutzer, Jennifer H. Marwitz, Adam P. Sima, Kristin M. Graham, Nancy H. Hsu, Ana Mills, Herman R. Lukow
JOURNAL OF HEAD TRAUMA REHABILITATION
(2020)
Article
Critical Care Medicine
Stefan W. Leichtle, Anand K. Sarma, Micheal Strein, Vishal Yajnik, Dennis Rivet, Adam Sima, Gretchen M. Brophy
NEUROCRITICAL CARE
(2020)
Article
Oncology
Charles F. Opalak, Matthew Parry, Andrew K. Rock, Adam P. Sima, Matthew T. Carr, Vyshak Chandra, Kathryn G. Workman, Aravind Somasundaram, William C. Broaddus
JOURNAL OF NEURO-ONCOLOGY
(2019)
Article
Clinical Neurology
Diego Iacono, Patricia Lee, Brian L. Edlow, Nichelle Gray, Bruce Fischl, Kimbra Kenney, Henry L. Lew, Scott Lozanoff, Peter Liacouras, John Lichtenberger, Kristen Dams-O'Connor, David Cifu, Sidney R. Hinds, Daniel P. Perl
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2020)
Article
Clinical Neurology
Ashraf S. Gorgey, Sally M. Abilmona, Adam Sima, Refka E. Khalil, Rehan Khan, Robert A. Adler
Article
Endocrinology & Metabolism
M. E. Holman, G. Chang, M. P. Ghatas, P. K. Saha, X. Zhang, M. R. Khan, A. P. Sima, R. A. Adler, A. S. Gorgey
Summary: The study showed that the combined intervention of TT + RT may help slow down bone loss following SCI over a longer period, suggesting it could be a valuable rehabilitation technique for individuals with spinal cord injury.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Adam P. Sima, Viviana A. Rodriguez, Keighly E. Bradbrook, Brian S. DiPace, Victoria Okhomina
Summary: There is a recent trend in medical research towards a more collaborative relationship between statisticians and clinical investigators. Guidelines and recommendations from the Clinical and Translational Science (CTSA) consortium were successfully applied to a statistical consulting service primarily staffed by graduate students, resulting in positive outcomes such as a high project request rate and excellent feedback from investigators.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Psychology, Developmental
Paul Wehman, Carol Schall, Jennifer McDonough, Adam Sima, Alissa Brooke, Whitney Ham, Holly Whittenburg, Valerie Brooke, Lauren Avellone, Erin Riehle
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2020)